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Anti-ACE2 Antibody-FITC (1Y227)
还可以产品编号 TMAY-00274F
Anti-ACE2 Antibody-FITC (1Y227) 是一种 FITC-conjugated Mouse 抗体，靶向 ACE2。Anti-ACE2 Antibody-FITC (1Y227) 可用于 FCM。
Anti-ACE2 Antibody-FITC (1Y227)
Anti-ACE2 Antibody-FITC (1Y227)
还可以产品编号 TMAY-00274F
Anti-ACE2 Antibody-FITC (1Y227) 是一种 FITC-conjugated Mouse 抗体，靶向 ACE2。Anti-ACE2 Antibody-FITC (1Y227) 可用于 FCM。
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抗原信息
| 产品描述 | Anti-ACE2 Antibody-FITC (1Y227) is a FITC-conjugated Mouse antibody targeting ACE2. Anti-ACE2 Antibody-FITC (1Y227) can be used in FCM. |
| Ig Type | Monoclonal Mouse IgG1 |
| 克隆号 | 1Y227 |
| 交叉反应 | Human |
| 验证活性 | Flow cytometric analysis of Human ACE2 expression on ACE2-transfected 293T cells. Cells were stained with FITC-conjugated anti-Human ACE2. The fluorescence histograms were derived from gated events with the forward and side light-scatter characteristics of intact cells. |
| 应用 | FCM |
| 推荐剂量 | 5 μl/Test, 0.1 mg/ml |
| 抗体种类 | Monoclonal |
| 宿主来源 | Mouse |
| 构建方式 | This antibody was produced from a hybridoma resulting from the fusion of a mouse myeloma with B cells obtained from a mouse immunized with purified, recombinant Human ACE2 (rh ACE2; TMPY-05266; NP_068576.1; Met1-Ser740) and conjugated with FITC under optimum conditions, the unreacted FITC was removed. |
| 纯化方式 | Protein A |
| 性状 | Liquid |
| 缓冲液 | PBS solution containing 0.5% BSA and 0.03%ProClin300 |
| 研究背景 | Angiotensin-converting enzyme 2 (ACE2), a first homolog of ACE, regulates the renin angiotensin system (RAS) by counterbalancing ACE activity. Accumulating evidence in recent years has demonstrated a physiological and pathological role of ACE2 in the cardiovascular, renal and respiratory systems. ACE2 also has an important role in blood pressure control. This enzyme, an homolog of ACE, hydrolyzes angiotensin (Ang) I to produce Ang-(1-9), which is subsequently converted into Ang-(1-7) by a neutral endopeptidase and ACE. ACE2 releases Ang-(1-7) more efficiently than its catalysis of Ang-(1-9) by cleavage of Pro(7)-Phe(8) bound in Ang II. Thus, the major biologically active product of ACE2 is Ang-(1-7), which is considered to be a beneficial peptide of the RAS cascade in the cardiovascular system. A physiological role for ACE2 has been implicated in hypertension, cardiac function, heart function and diabetes, and as a receptor of the severe acute respiratory syndrome coronavirus. In the acute respiratory distress syndrome (ARDS), ACE, AngII, and AT1R promote the disease pathogenesis, whereas ACE2 and the AT2R protect from ARDS. Importantly, ACE2 has been identified as a key SARS-coronavirus receptor and plays a protective role in severe acute respiratory syndrome (SARS) pathogenesis. Furthermore, the recent explosion of research into the ACE2 homolog, collectrin, has revealed a new physiological function of ACE2 as an amino acid transporter, which explains the pathogenic role of gene mutations in Hartnup disorder. This review summarizes and discusses the recently unveiled roles for ACE2 in disease pathogenesis. |
| 偶联 | FITC |
| 其他可选修饰符 | PE |
| 可提供抗体种类 | 2 |
| 免疫原 | Recombinant Human ACE2 Protein (TMPY-05266) |
| 抗原种属 | Human |
存储&运输
| 储存方式 | Store at 2°C-8°C for 12 months, do not freeze. Keep away from direct sunlight. |
| 运输方式 | Shipping with blue ice. |
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比如您的给药剂量是 10 mg/kg ，每只动物体重 20 g ，给药体积 100 μL ， 
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