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Mannan Binding Lectin/MBL2 Protein, Human, Recombinant

产品编号 TMPY-03565

别名: MBPD, MBP-C, mannose-binding lectin (protein C) 2, soluble, COLEC1, HSMBPC, MBP1, MBL, MBL2D, MBP

Mannan Binding Lectin/MBL2 Protein, Human, Recombinant is expressed in CHO mammalian cells. The predicted molecular weight is 24 kDa and the accession number is P11226.

TargetMol的所有产品和服务仅用于科学研究，不能被用于人体，我们也不向个人提供产品和服务。

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Mannan Binding Lectin/MBL2 Protein, Human, Recombinant

规格	价格/CNY		货期	数量
100 μg	￥ 4,470		现货
200 μg	￥ 7,900		5日内发货
500 μg	￥ 16,710		5日内发货

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生物活性	Testing in progress
产品描述	Mannan Binding Lectin/MBL2 Protein, Human, Recombinant is expressed in CHO mammalian cells. The predicted molecular weight is 24 kDa and the accession number is P11226.

种属	Human
表达系统	CHO Cells
标签	Tag Free
蛋白编号	P11226
别名	MBPD, MBP-C, mannose-binding lectin (protein C) 2, soluble, COLEC1, HSMBPC, MBP1, MBL, MBL2D, MBP
蛋白构建	Human MBL (NP_000233.1) (Met1-Ile 248)
蛋白纯度	> 95 % as determined by SDS-PAGE
分子量	24 kDa (predicted)

内毒素	< 1.0 EU/μg of the protein as determined by the LAL method.
缓冲液	Lyophilized from a solution filtered through a 0.22 μm filter, containing PBS, pH 7.4. Typically, a mixture containing 5% to 8% trehalose, mannitol, and 0.01% Tween 80 is incorporated as a protective agent before lyophilization.
复溶方法	A Certificate of Analysis (CoA) containing reconstitution instructions is included with the products. Please refer to the CoA for detailed information.
存储	It is recommended to store recombinant proteins at -20°C to -80°C for future use. Lyophilized powders can be stably stored for over 12 months, while liquid products can be stored for 6-12 months at-80℃. For reconstituted proteinsolutions, the solution can be stored at -20°c to -80'c for at least 3 months. Please avoid multiple freeze-thaw cycles and store products in aliquots.
运输方式	In general, Lyophilized powders are shipping with blue ice.
研究背景	MBL (mannose-binding lectin) is primarily a liver-derived collagen-like serum protein, which binds sugar structures on micro-organisms and dying host cells and is one of the four known mediators that initiate activation of the complement system via the lectin pathway. MBL and the ficolins (Ficolin-1, Ficolin-2, and Ficolin-3) are soluble collagen-like proteins that are involved in innate immune defense. They bind sugar structures or acetylated compounds present on microorganisms and dying host cells and they initiate activation of the lectin complement pathway in varying degrees. MBL2 encodes the mannose-binding lectin, which is a key player in the innate immune system and has recently been found to play a role in the development of type 1 diabetes and gestational diabetes mellitus. Common variant alleles situated both in the promoter and structural regions of the MBL2 gene influence the stability and the serum concentration of the protein. Several polymorphisms in the promoter and structural regions of MBL2 adversely affect the plasma concentration and the oligomeric state of MBL. The possession of mutant alleles has been linked to disease outcomes for a variety of bacterial and viral infections. Mutant MBL2 haplotypes have been linked to disease progression and response to therapy in HCV infection.

参考文献

1. Garred P, et al. (2006) Mannose-binding lectin and its genetic variants. Genes Immun. 7(2): 85-94. 2. Brown KS, et al. (2007) Mannan binding lectin and viral hepatitis. Immunol Lett. 108(1): 34-44. 3. Garred P. (2008) Mannose-binding lectin genetics: from A to Z. Biochem Soc Trans. 36(Pt 6): 1461-6. 4. Garred P, et al. (2009) MBL2, FCN1, FCN2 and FCN3-The genes behind the initiation of the lectin pathway of complement. Mol Immunol. 46(14): 2737-44. 5. Muller YL, et al. (2010) Functional Variants in MBL2 Are Associated With Type 2 Diabetes and Pre-Diabetes Traits in Pima Indians and the Old Order Amish. Diabetes. 59(8): 2080-5.

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Keywords

Mannan Binding Lectin/MBL2 Protein, Human, Recombinant MBPD MBP-1 MBP-C mannose-binding lectin (protein C) 2, soluble COLEC1 HSMBPC COLEC 1 MBP1 MBP 1 COLEC-1 MBL MBL2D MBP recombinant recombinant-proteins proteins protein

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