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Anti-SYNCRIP Antibody (3C999) 是一种 Rabbit 抗体,靶向 SYNCRIP。Anti-SYNCRIP Antibody (3C999) 可用于 WB,ICC,IF,IHC。
Anti-SYNCRIP Antibody (3C999) 是一种 Rabbit 抗体,靶向 SYNCRIP。Anti-SYNCRIP Antibody (3C999) 可用于 WB,ICC,IF,IHC。
规格 | 价格 | 库存 | 数量 |
---|---|---|---|
50 μL | ¥ 1,490 | 5日内发货 | |
100 μL | ¥ 2,485 | 5日内发货 |
产品描述 | Anti-SYNCRIP Antibody (3C999) is a Rabbit antibody targeting SYNCRIP. Anti-SYNCRIP Antibody (3C999) can be used in WB,ICC,IF,IHC. |
别名 | Synaptotagmin-binding, NSAP1, NS1-associated protein 1, HNRPQ, hnRNP Q, Heterogeneous nuclear ribonucleoprotein Q, GRY-RBP, Glycine- and tyrosine-rich RNA-binding protein, cytoplasmic RNA-interacting protein |
Ig Type | IgG |
克隆号 | 3C999 |
交叉反应 | Human,Mouse,Rat |
验证活性 | 1. Western blot analysis of hnRNP Q on K562 cell lysate using anti-hnRNP Q antibody at 1/1,000 dilution. 2. Immunohistochemical analysis of paraffin-embedded rat testis tissue using anti-hnRNP Q antibody. Counter stained with hematoxylin. 3. Immunohistochemical analysis of paraffin-embedded human thyroid gland tissue using anti-hnRNP Q antibody. Counter stained with hematoxylin. 4. Immunohistochemical analysis of paraffin-embedded human breast tissue using anti-hnRNP Q antibody. Counter stained with hematoxylin. 5. Immunohistochemical analysis of paraffin-embedded human kidney tissue using anti-hnRNP Q antibody. Counter stained with hematoxylin. 6. ICC staining hnRNP Q in LOVO cells (green). The nuclear counter stain is DAPI (blue). Cells were fixed in paraformaldehyde, permeabilised with 0.25% Triton X100/PBS. 7. ICC staining hnRNP Q in SiHa cells (green). The nuclear counter stain is DAPI (blue). Cells were fixed in paraformaldehyde, permeabilised with 0.25% Triton X100/PBS. |
应用 | |
推荐剂量 | WB: 1:500-2000; IHC: 1:50-200; ICC: 1:50-200 |
抗体种类 | Monoclonal |
宿主来源 | Rabbit |
构建方式 | Recombinant Antibody |
纯化方式 | ProA affinity purified |
性状 | Liquid |
缓冲液 | 1*TBS (pH7.4), 1%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide. |
研究背景 | Pre-mRNA splicing is a critical step in the posttranscriptional regulation of gene expression. Heterogeneous nuclear ribonucleoprotein Q (hnRNP Q) is involved in RNA processing and is necessary for efficient pre-mRNA splicing. hnRNP is widely expressed and developmentally regulated. hnRNP Q interacts with survival motor neuron protein (SMN). Loss of function of SMN results in spinal muscular atrophy, a common neurodegenerative disease. The most common deletion in SMN genes disrupts the interaction between SMN and hnRNP Q. hnRNP Q is upregulated after midnight, and this upregulation correlates with an abrupt decline in AANAT, the key enzyme in melatonin synthesis. Rhythmic AANAT mRNA degradation mediated in part by hnRNP Q implicates this enzyme in the regulation of circadian oscillation. |
偶联 | Unconjugated |
免疫原 | Recombinant Protein: C-terminal human hnRNP Q |
抗原种属 | human |
Uniprot ID |
分子量 | Theoretical: 70 kDa. |
储存方式 | Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. |
运输方式 | Shipping with blue ice. |
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