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Anti-CD33 Monoclonal Antibody

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产品编号 TMAZ-0119

别名 Sialic acid-binding Ig-like lectin 3, Myeloid cell surface antigen CD33, gp67

Anti-CD33 Monoclonal Antibody is a humanized rabbit antibody targeting CD33. Anti-CD33 Monoclonal Antibody can be used in ELISA, FCM, IF. 可用于 ELISA,FCM,IF。

Anti-CD33 Monoclonal Antibody

Anti-CD33 Monoclonal Antibody

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产品编号 TMAZ-0119 别名 Sialic acid-binding Ig-like lectin 3, Myeloid cell surface antigen CD33, gp67

Anti-CD33 Monoclonal Antibody is a humanized rabbit antibody targeting CD33. Anti-CD33 Monoclonal Antibody can be used in ELISA, FCM, IF. 可用于 ELISA,FCM,IF。

规格价格库存数量
25 μg
¥ 694
7日内发货
50 μg
¥ 832
7日内发货
100 μg
¥ 1,164
7日内发货
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产品介绍

生物活性
产品描述
Anti-CD33 Monoclonal Antibody is a humanized rabbit antibody targeting CD33. Anti-CD33 Monoclonal Antibody can be used in ELISA,FCM,IF.
别名Sialic acid-binding Ig-like lectin 3, Myeloid cell surface antigen CD33, gp67
Ig Type
Rabbit monoclonal IgG
交叉反应
Human
验证活性
Flow cytometry analysis of CD33 overexpressed 340F cells with TMAZ-0119, followed by goat anti-rabbit IgG-ABflo 647 (red line). The isotype control is rabbit IgG (black line).
应用ELISAFCMIF
推荐剂量
0.1-0.2 μg/10E6 cells for FCM; 1 ng/μl for ELISA
抗体种类
Monoclonal
宿主来源Rabbit
亚细胞定位Single-pass type I membrane
构建方式This antibody was produced from a rabbit immunized with purified, recombinant human extracellular domain of CD33 protein.
纯化方式Protein A Affinity Purified
性状Liquid
缓冲液0.22 μm filtered solution in PBS.
纯度> 95% as determined by SDS-PAGE.
研究背景Sialic-acid-binding immunoglobulin-like lectin (Siglec) that plays a role in mediating cell-cell interactions and in maintaining immune cells in a resting state (PubMed: 10611343, PubMed: 11320212, PubMed: 15597323). Preferentially recognizes and binds alpha-2,3- and more avidly alpha-2,6-linked sialic acid-bearing glycans (PubMed: 7718872). Upon engagement of ligands such as C1q or syalylated glycoproteins, two immunoreceptor tyrosine-based inhibitory motifs (ITIMs) located in CD33 cytoplasmic tail are phosphorylated by Src-like kinases such as LCK (PubMed: 10887109, PubMed: 28325905). These phosphorylations provide docking sites for the recruitment and activation of protein-tyrosine phosphatases PTPN6/SHP-1 and PTPN11/SHP-2 (PubMed: 10206955, PubMed: 10556798, PubMed: 10887109). In turn, these phosphatases regulate downstream pathways through dephosphorylation of signaling molecules (PubMed: 10206955, PubMed: 10887109). One of the repressive effect of CD33 on monocyte activation requires phosphoinositide 3-kinase/PI3K (PubMed: 15597323)
偶联与修饰
偶联
Unconjugated
其他可选修饰符
Biotin
可提供抗体种类
2
抗原信息
免疫原
CD33
抗原种属
Human
基因ID
945
Uniprot ID
P20138
研究领域
Cancer Research
化学信息
分子量150 kDa
存储&运输
储存方式Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles.
运输方式Shipping with blue ice.

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