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Anti-CD69 Monoclonal Antibody
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产品编号 TMAZ-0384
别名 MLR-3, Leukocyte surface antigen Leu-23, GP32/28, Early T-cell activation antigen p60, Early activation antigen CD69, EA1, C-type lectin domain family 2 member C, BL-AC/P26, Activation inducer molecule
Anti-CD69 Monoclonal Antibody is an unconjugated humanized rabbit antibody targeting CD69. Anti-CD69 Monoclonal Antibody can be used in ELISA, FCM.
Anti-CD69 Monoclonal Antibody
Anti-CD69 Monoclonal Antibody
还可以产品编号 TMAZ-0384 别名 MLR-3, Leukocyte surface antigen Leu-23, GP32/28, Early T-cell activation antigen p60, Early activation antigen CD69, EA1, C-type lectin domain family 2 member C, BL-AC/P26, Activation inducer molecule
Anti-CD69 Monoclonal Antibody is an unconjugated humanized rabbit antibody targeting CD69. Anti-CD69 Monoclonal Antibody can be used in ELISA, FCM.
| 规格 | 价格 | 库存 | 数量 |
|---|---|---|---|
| 25 μg | ¥ 1,250 | 7日内发货 | |
| 50 μg | ¥ 1,500 | 7日内发货 | |
| 100 μg | ¥ 2,099 | 7日内发货 |
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Anti-CD69 Monoclonal Antibody 相关产品
产品介绍
生物活性
偶联与修饰
抗原信息
化学信息
| 产品描述 | Anti-CD69 Monoclonal Antibody is an unconjugated humanized rabbit antibody targeting CD69. Anti-CD69 Monoclonal Antibody can be used in ELISA, FCM. |
| 别名 | MLR-3, Leukocyte surface antigen Leu-23, GP32/28, Early T-cell activation antigen p60, Early activation antigen CD69, EA1, C-type lectin domain family 2 member C, BL-AC/P26, Activation inducer molecule |
| Ig Type | Rabbit monoclonal IgG |
| 交叉反应 | Human |
| 验证活性 | Flow cytometry analysis of CD69 overexpressed 454F cells with TMAZ-0384, followed by goat anti-rabbit IgG-ABflo 647 (red line). The isotype control is rabbit IgG (black line). |
| 应用 | |
| 推荐剂量 | 0.1-0.2 μg/10E6 cells for FCM; 1 ng/μl for ELISA |
| 抗体种类 | Monoclonal |
| 宿主来源 | Rabbit |
| 亚细胞定位 | Secreted |
| 构建方式 | This antibody was produced from a rabbit immunized with purified, recombinant human extracellular domain of CD69 protein. |
| 纯化方式 | Protein A Affinity Purified |
| 性状 | Liquid |
| 缓冲液 | 0.22 μm filtered solution in PBS. |
| 纯度 | > 95% as determined by SDS-PAGE. |
| 研究背景 | Transmembrane protein expressed mainly on T-cells resident in mucosa that plays an essential role in immune cell homeostasis. Rapidly expressed on the surface of platelets, T-lymphocytes and NK cells upon activation by various stimuli, such as antigen recognition or cytokine signaling, stimulates different signaling pathways in different cell types (PubMed:24752896, PubMed:26296369, PubMed:35930205). Negatively regulates Th17 cell differentiation through its carbohydrate dependent interaction with galectin-1/LGALS1 present on immature dendritic cells (PubMed:24752896). Association of CD69 cytoplasmic tail with the JAK3/STAT5 signaling pathway regulates the transcription of RORgamma/RORC and, consequently, differentiation toward the Th17 lineage (By similarity). Acts also via the S100A8/S100A9 complex present on peripheral blood mononuclear cells to promote the conversion of naive CD4 T-cells into regulatory T-cells (PubMed:26296369). Acts as an oxidized low-density lipoprotein (oxLDL) receptor in CD4 T-lymphocytes and negatively regulates the inflammatory response by inducing the expression of PDCD1 through the activation of NFAT (PubMed:35930205). Participates in adipose tissue-derived mesenchymal stem cells (ASCs)-mediated protection against P. aeruginosa infection. Mechanistically, specifically recognizes P. aeruginosa to promote ERK1 activation, followed by granulocyte-macrophage colony-stimulating factor (GM-CSF) and other inflammatory cytokines secretion (PubMed:34841721). In eosinophils, induces IL-10 production through the ERK1/2 pathway (By similarity). Negatively regulates the chemotactic responses of effector lymphocytes and dendritic cells (DCs) to sphingosine 1 phosphate/S1P by acting as a S1PR1 receptor agonist and facilitating the internalization and degradation of the receptor (PubMed:37039481) |
| 偶联 | Unconjugated |
| 其他可选修饰符 | Biotin |
| 可提供抗体种类 | 2 |
| 免疫原 | CD69 |
| 抗原种属 | Human |
| 基因ID | |
| Uniprot ID | |
| 研究领域 | Immunology Research |
| 分子量 | 150 kDa |
存储&运输
| 储存方式 | Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. |
| 运输方式 | Shipping with blue ice. |
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比如您的给药剂量是 10 mg/kg ，每只动物体重 20 g ，给药体积 100 μL ， 
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