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HGFR/c-Met Protein, Human, Recombinant (aa 956-1390, His & GST)

产品编号 TMPY-04379

HGFR/c-Met Protein, Human, Recombinant (aa 956-1390, His & GST) is expressed in Baculovirus insect cells with His and GST tag. The predicted molecular weight is 76.8 kDa and the accession number is P08581-1.

HGFR/c-Met Protein, Human, Recombinant (aa 956-1390, His & GST)

产品编号 TMPY-04379

规格	价格	库存	数量
50 μg	¥ 3,170	5日内发货

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产品信息

生物活性	1. The specific activity was determined to be 10 nmol/min/mg using MBP as substrate. 2. Measured by its binding ability in a functional ELISA. Immobilized human HGFR (aa 956-1390) at 10 μg/ml (100 μl/well) can bind biotinylated human HGF-his with a linear range of 15.6-125 ng/ml.
产品描述	HGFR/c-Met Protein, Human, Recombinant (aa 956-1390, His & GST) is expressed in Baculovirus insect cells with His and GST tag. The predicted molecular weight is 76.8 kDa and the accession number is P08581-1.
种属	Human
表达系统	Baculovirus Insect Cells
标签	His, GST
蛋白编号	P08581-1
别名	RCCP2,MET proto-oncogene, receptor tyrosine kinase,HGFR,DFNB97,c-Met,AUTS9
蛋白构建	A DNA sequence encoding the human MET (P08581-1) (Lys956-Ser1390) was fused with the N-terminal polyhistidine-tagged GST tag at the N-terminus. Predicted N terminal: Met
蛋白纯度	> 90 % as determined by SDS-PAGE
分子量	76.8 kDa (predicted); 68 kDa (reducing conditions)
内毒素	< 1.0 EU/μg of the protein as determined by the LAL method.
缓冲液	Supplied as sterile 20 mM Tris, 500 mM NaCl, pH 7.4, 10% glycerol, 3 mM DTT.
复溶方法	A Certificate of Analysis (CoA) containing reconstitution instructions is included with the products. Please refer to the CoA for detailed information.
存储	It is recommended to store the product under sterile conditions at -20°C to -80°C. Samples are stable for up to 12 months. Please avoid multiple freeze-thaw cycles and store products in aliquots.
运输方式	Kinases are highly recommended to be shipped at frozen temperature with blue ice or dry ice.
研究背景	Hepatocyte growth factor receptor (HGFR), also known as c-Met or mesenchymal-epithelial transition factor (MET), is a receptor tyrosine kinase (RTK) that is overexpressed and/or mutated in a variety of malignancies. HGFR protein is produced as a single-chain precursor, and HGF is the only known ligand. Normal HGF/HGFR signaling is essential for embryonic development, tissue repair, or wound healing, whereas aberrantly active HGFR has been strongly implicated in tumorigenesis, particularly in the development of invasive and metastatic phenotypes. HGFR protein is a multifaceted regulator of growth, motility, and invasion, and is normally expressed by cells of epithelial origin. Preclinical studies suggest that targeting aberrant HGFR signaling could be an attractive therapy in cancer.Cancer ImmunotherapyImmune CheckpointImmunotherapyTargeted Therapy