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Anti-NGAL/Lipocalin-2 Antibody-HRP (4O488)
还可以产品编号 TMAY-03735H
Anti-NGAL/Lipocalin-2 Antibody-HRP (4O488) 是一种 HRP-conjugated Mouse 抗体，靶向 NGAL/Lipocalin-2。Anti-NGAL/Lipocalin-2 Antibody-HRP (4O488) 可用于 ELISA。
Anti-NGAL/Lipocalin-2 Antibody-HRP (4O488)
Anti-NGAL/Lipocalin-2 Antibody-HRP (4O488)
还可以产品编号 TMAY-03735H
Anti-NGAL/Lipocalin-2 Antibody-HRP (4O488) 是一种 HRP-conjugated Mouse 抗体，靶向 NGAL/Lipocalin-2。Anti-NGAL/Lipocalin-2 Antibody-HRP (4O488) 可用于 ELISA。
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| 产品描述 | Anti-NGAL/Lipocalin-2 Antibody-HRP (4O488) is a HRP-conjugated Mouse antibody targeting NGAL/Lipocalin-2. Anti-NGAL/Lipocalin-2 Antibody-HRP (4O488) can be used in ELISA. |
| Ig Type | Monoclonal Mouse IgG2a |
| 克隆号 | 4O488 |
| 交叉反应 | Rat |
| 应用 | ELISA |
| 推荐剂量 | ELISA: 0.1-1 μg/mL |
| 抗体种类 | Monoclonal |
| 宿主来源 | Mouse |
| 构建方式 | This antibody was produced from a hybridoma resulting from the fusion of a mouse myeloma with B cells obtained from a mouse immunized with purified, recombinant Rat NGAL / LCN2 / Lipocalin-2 (rR NGAL / LCN2 / Lipocalin-2; TMPY-02316; P30152; Met1-Asn198). The IgG fraction of the cell culture supernatant was purified by Protein A affinity chromatography and conjugated with horseradish-peroxidase (HRP). |
| 纯化方式 | Protein A |
| 性状 | Liquid |
| 缓冲液 | 0.2 μm filtered solution in PBS |
| 研究背景 | Lipocalin-2 (LCN2), also known as neutrophil gelatinase-associated lipocalin (NGAL), is a 25 kDa protein belonging to the lipocalin superfamily. It was initially found in activated neutrophils, however, many other cells, like kidney tubular cells, may produce NGAL in response to various insults. This protein is released from injured tubular cells after various damaging stimuli, is already known by nephrologists as one of the most promising biomarkers of incoming Acute Kidney Injury (AKI). Recent evidence also suggests its role as a biomarker in a variety of other renal and non-renal conditions. Moreover, recent studies seem to suggest a potential involvement of this factor also in the genesis and progression of chronic kidney diseases. NGAL is the first known mammalian protein that specifically binds organic molecules called siderophores, which are high-affinity iron chelators. NGAL, first known as an antibacterial factor of natural immunity, and an acute-phase protein, is currently one of the most interesting and enigmatic proteins involved in the process of tumor development. acting as an intracellular iron carrier and protecting MMP9 from proteolytic degradation, NGAL has a clear pro-tumoral effect, as has already been observed in different tumors (e.g. breast, stomach, esophagus, brain) in humans. In thyroid carcinomas, NGAL is strongly induced by NF-kB, an important factor involved both in tumor growth and in the link between chronic inflammation and neoplastic development. Thus, Lipocalin-2 (LCN2/NGAL) has been implicated in a variety of processes including cell differentiation, proliferation, survival, and morphogenesis. |
| 偶联 | HRP |
| 其他可选修饰符 | Unconjugated |
| 可提供抗体种类 | 2 |
| 免疫原 | Recombinant Rat NGAL / LCN2 / Lipocalin-2 Protein (TMPY-02316) |
| 抗原种属 | Rat |
存储&运输
| 储存方式 | Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. Preservative-Free. Keep away from direct sunlight. |
| 运输方式 | Shipping with blue ice. |
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比如您的给药剂量是 10 mg/kg ，每只动物体重 20 g ，给药体积 100 μL ， 
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