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Anti-Phospho-PPP2CA (Tyr307) Antibody (7S944) 是一种抗体,靶向 Phospho-PPP2CA (Tyr307)。Anti-Phospho-PPP2CA (Tyr307) Antibody (7S944) 可用于 ELISA, WB。
Anti-Phospho-PPP2CA (Tyr307) Antibody (7S944) 是一种抗体,靶向 Phospho-PPP2CA (Tyr307)。Anti-Phospho-PPP2CA (Tyr307) Antibody (7S944) 可用于 ELISA, WB。
规格 | 价格 | 库存 | 数量 |
---|---|---|---|
50 μL | ¥ 1,310 | 5日内发货 | |
100 μL | ¥ 2,190 | 5日内发货 |
产品描述 | Anti-Phospho-PPP2CA (Tyr307) Antibody (7S944) is an antibody targeting Phospho-PPP2CA (Tyr307). Anti-Phospho-PPP2CA (Tyr307) Antibody (7S944) can be used in ELISA, WB. |
别名 | Phospho-PPP2CA (Y307) |
Ig Type | Rabbit IgG |
克隆号 | 7S944 |
交叉反应 | Human |
验证活性 | Western Blot -Positive WB detected in A549 whole cell lysate(treated with EGF or not) -All lanes Phospho-PPP2CA antibody at 0.95μg/ml -Secondary: Goat polyclonal to rabbit IgG at 1/50000 dilution -Predicted band size: 35 KDa -Observed band size: 35 KDa |
应用 | ELISA, WB |
推荐剂量 | WB:1:500-1:5000. |
抗体种类 | Monoclonal |
亚细胞定位 | Cytoplasm. Nucleus. Chromosome, centromere. Cytoplasm, cytoskeleton, spindle pole. |
构建方式 | Recombinant Antibody |
纯化方式 | Affinity-chromatography |
性状 | Liquid |
缓冲液 | Phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
研究背景 | PP2A is the major phosphatase for microtubule-associated proteins (MAPs). PP2A can modulate the activity of phosphorylase B kinase casein kinase 2, mitogen-stimulated S6 kinase, and MAP-2 kinase. Cooperates with SGO2 to protect centromeric cohesin from separase-mediated cleavage in oocytes specifically during meiosis I. Can dephosphorylate SV40 large T antigen and p53/TP53. Activates RAF1 by dephosphorylating it at 'Ser-259'. Mediates dephosphorylation of WEE1, preventing its ubiquitin-mediated proteolysis, increasing WEE1 protein levels, and promoting the G2/M checkpoint. Mediates dephosphorylation of MYC; promoting its ubiquitin-mediated proteolysis: interaction with AMBRA1 enhances interaction between PPP2CA and MYC. Mediates dephosphorylation of FOXO3; promoting its stabilization: interaction with AMBRA1 enhances interaction between PPP2CA and FOXO3. |
偶联 | Unconjugated |
免疫原 | A synthetic peptide: Human Phospho-PPP2CA (Y307) |
抗原种属 | Human |
基因ID | 5515 |
Uniprot ID | |
研究领域 | Signal Transduction |
储存方式 | Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. |
运输方式 | Shipping with blue ice. |
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