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顶部生物活性储存和溶解信息计算器

Anti-IGF1/IGF-I Antibody (9D219)

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产品编号 TMAH-00598

别名 胰岛素样生长因子, somatomedin C, MGF, insulin-like growth factor 1, IGF‑I, IGF-I, IGFI, IGF1A, IGF-1

Anti-IGF1/IGF-I Antibody (9D219) 是一种抗体，靶向 IGF1/IGF-I。Anti-IGF1/IGF-I Antibody (9D219) 可用于 ELISA,IHC。

Anti-IGF1/IGF-I Antibody (9D219)

Anti-IGF1/IGF-I Antibody (9D219)

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产品编号 TMAH-00598 别名 胰岛素样生长因子, somatomedin C, MGF, insulin-like growth factor 1, IGF‑I, IGF-I, IGFI, IGF1A, IGF-1

Anti-IGF1/IGF-I Antibody (9D219) 是一种抗体，靶向 IGF1/IGF-I。Anti-IGF1/IGF-I Antibody (9D219) 可用于 ELISA,IHC。

规格价格库存数量
50 μL
¥ 1,305
5日内发货
100 μL
¥ 2,180
5日内发货
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产品介绍

生物活性
产品描述
Anti-IGF1/IGF-I Antibody (9D219) is an antibody targeting IGF1/IGF-I. Anti-IGF1/IGF-I Antibody (9D219) can be used in ELISA,IHC.
别名胰岛素样生长因子, somatomedin C, MGF, insulin-like growth factor 1, IGF‑I, IGF-I, IGFI, IGF1A, IGF-1
Ig Type
hIgG2
克隆号
9D219
交叉反应
Human
验证活性
1. IHC image of TMAH-00598 diluted at 1:100 and staining in paraffin-embedded human liver tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a Goat anti-Human IgG labeled by HRP and visualized using 0.05% DAB.
2. IHC image of TMAH-00598 diluted at 1:100 and staining in paraffin-embedded human pancreatic cancer performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a Goat anti-Human IgG labeled by HRP and visualized using 0.05% DAB.
应用ELISAIHC
推荐剂量
IHC:1:50-1:200.
抗体种类
Monoclonal
亚细胞定位Secreted.
构建方式Recombinant Antibody
纯化方式Affinity-chromatography
性状Liquid
缓冲液Preservative: 0.03% Proclin 300. Constituents: 50% Glycerol, 0.01M PBS, PH 7.4.
研究背景The insulin-like growth factors, isolated from plasma, are structurally and functionally related to insulin but have a much higher growth-promoting activity. May be a physiological regulator of [1-14C]-2-deoxy-D-glucose (2DG) transport and glycogen synthesis in osteoblasts. Stimulates glucose transport in bone-derived osteoblastic (PyMS) cells and is effective at much lower concentrations than insulin, not only regarding glycogen and DNA synthesis but also with regard to enhancing glucose uptake. May play a role in synapse maturation. Ca(2+)-dependent exocytosis of IGF1 is required for sensory perception of smell in the olfactory bulb. Acts as a ligand for IGF1R. Binds to the alpha subunit of IGF1R, leading to the activation of the intrinsic tyrosine kinase activity which autophosphorylates tyrosine residues in the beta subunit thus initiatiating a cascade of down-stream signaling events leading to activation of the PI3K-AKT/PKB and the Ras-MAPK pathways. Binds to integrins ITGAV:ITGB3 and ITGA6:ITGB4. Its binding to integrins and subsequent ternary complex formation with integrins and IGFR1 are essential for IGF1 signaling. Induces the phosphorylation and activation of IGFR1, MAPK3/ERK1, MAPK1/ERK2 and AKT1.
偶联与修饰
偶联
Unconjugated
抗原信息
免疫原
Recombinant Protein: Human IGF1 Protein
抗原种属
Human
基因名称
IGF1
基因ID
3479
Uniprot ID
P05019
研究领域
Cancer, Developmental biology, Signal transduction
存储&运输
储存方式Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles.
运输方式Shipping with blue ice.

计算器

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关键词

IGF1IGF 1

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