规格

价格

库存

数量

10 mg

待询

50 mg

待询

生物活性

产品描述

Anticanceragent 201 (Compound 2f) exhibits IC50 values in the low micromolar range across various tumor cell lines. It demonstrates high in vitro cytotoxicity against CCRF-CEM cells by inducing apoptosis through the activation of caspase-3 in the mitochondrial intrinsic pathway, cleavage of PARP, and reduced expression of Bcl-2 and Bcl-XL proteins. Anticanceragent 201 can be utilized in cancer research.

体外活性

抗癌剂201 (Compound 2f) (3.5 μM, 17.5 μM; 24 小时) 能显著诱导细胞毒性反应，提高凋亡细胞数量，并导致CCRF-CEM细胞的线粒体膜电位以剂量形式降低。此外，该化合物在CCRF-CEM细胞中阻碍或减慢G0/G1期的细胞周期、降低S期细胞比例，还能够抑制RNA合成。抗癌剂201 在包括多药耐药变异体在内的8种肿瘤和2种正常成纤维细胞系中显示细胞毒活性。细胞系 CCRF-CEM CEM-DNR K562 K562-TAX A549 HCT116 HCT116p53 -/- U20S BJ MRC-5 IC50 (μM) 3.5 4.9 23 17 11 10 18 19 ＞50 27。