Name: Vorsetuzumab mafodotin
Brand: TargetMol
SKU: T9901A-221
Rating: 4.5 (1 reviews)

规格

价格

库存

数量

1 mg

¥ 5,950

2-4周

5 mg

¥ 15,200

2-4周

生物活性

产品描述	Vorsetuzumab mafodotin (SGN‑75) is an auristatin-based, CD70-targeted antibody-drug conjugate (ADC), composed of the humanized monoclonal antibody Vorsetuzumab and the ADC cytotoxic molecule MMAF, and exerts antitumor effects.
靶点活性	SKOV3 cells:29 ng/mL
体外活性	Vorsetuzumab mafodotin(SGN‑75)在 0.01～10000 ng/mL 浓度范围内持续作用 96 小时，可呈剂量依赖性诱导细胞毒性， IC50 为 29 ng/mL [1]。
体内活性	Vorsetuzumab mafodotin(SGN‑75)以 3 mg/kg 剂量、间隔 4 天进行四次腹腔注射给药，能够显著降低小鼠中位肿瘤体积，并有效抑制肿瘤生长进程 [1]。
别名	SGN-75, h1F6-mcMMAF, Anti-TNFSF7 / CD27L / CD70 Reference Antibody, Anti-Human CD70 Recombinant Antibody
反应种属	Human
应用	ELISA FCM Functional assay
抗体种类	Monoclonal, ADC
缓冲液	Supplied as a sterile solution in a buffered formulation system (e.g., phosphate-, citrate-, or amino acid-based). Please refer to the CoA for lot-specific composition.
内毒素	<1.0 EU/mg

抗体信息

同型

IgG1

偶联与修饰

偶联

MMAF

抗原信息

化学信息

分子量	146.1 kDa
CAS No.	1165741-01-4

储存&溶解度

存储	Store at -20°C Shipping with blue ice. 实际储存温度请以COA为准

Vorsetuzumab mafodotin