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Anti-RAGE Antibody (4J597)
还可以产品编号 TMAY-01944
Anti-RAGE Antibody (4J597) 是一种 Mouse 抗体，靶向 RAGE。Anti-RAGE Antibody (4J597) 可用于 IHC-P。
Anti-RAGE Antibody (4J597)
Anti-RAGE Antibody (4J597)
还可以产品编号 TMAY-01944
Anti-RAGE Antibody (4J597) 是一种 Mouse 抗体，靶向 RAGE。Anti-RAGE Antibody (4J597) 可用于 IHC-P。
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产品介绍
生物活性
偶联与修饰
抗原信息
| 产品描述 | Anti-RAGE Antibody (4J597) is a Mouse antibody targeting RAGE. Anti-RAGE Antibody (4J597) can be used in IHC-P. |
| Ig Type | Monoclonal Mouse IgG1 |
| 克隆号 | 4J597 |
| 交叉反应 | Human |
| 验证活性 | 1. Immunochemical staining of human AGER in human kidney with mouse monoclonal antibody (1:200, formalin-fixed paraffin embedded sections). 2. Immunochemical staining of human AGER in human lung with mouse monoclonal antibody (1:1000, formalin-fixed paraffin embedded sections). |
| 应用 | IHC-P |
| 推荐剂量 | IHC-P: 1:100-1:500 |
| 抗体种类 | Monoclonal |
| 宿主来源 | Mouse |
| 构建方式 | This antibody was produced from a hybridoma resulting from the fusion of a mouse myeloma with B cells obtained from a mouse immunized with purified, recombinant Human RAGE/AGER (rh RAGE/AGER; TMPY-02927; NP_001127; Met1-Ala344). The IgG fraction of the cell culture supernatant was purified by Protein A affinity chromatography. |
| 纯化方式 | Protein A |
| 性状 | Liquid |
| 缓冲液 | 0.2 μm filtered solution in PBS with 0.02% Tween 80, pH7.0 |
| 研究背景 | Receptor for Advanced Glycosylation End Products (RAGE, or AGER) is a member of the immunoglobulin super-family transmembrane proteins, as a signal transduction receptor which binds advanced glycation endproducts, certain members of the S100/calgranulin family of proteins, high mobility group box 1 (HMGB1), advanced oxidation protein products, and amyloid (beta-sheet fibrils). Initial studies investigating the role of RAGE in renal dysfunction focused on diabetes, neurodegenerative disorders, and inflammatory responses. However, RAGE also has roles in the pathogenesis of renal disorders that are not associated with diabetes, such as obesity-related glomerulopathy, doxorubicin-induced nephropathy, hypertensive nephropathy, lupus nephritis, renal amyloidosis, and ischemic renal injuries. RAGE represents an important factor in innate immunity against pathogens, but it also interacts with endogenous ligands, resulting in chronic inflammation. RAGE signaling has been implicated in multiple human illnesses, including atherosclerosis, arthritis, Alzheimer's disease, atherosclerosis and aging associated diseases. |
| 偶联 | Unconjugated |
| 免疫原 | Recombinant Human RAGE/AGER Protein (TMPY-02927) |
| 抗原种属 | Human |
存储&运输
| 储存方式 | Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. Preservative-Free. |
| 运输方式 | Shipping with blue ice. |
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比如您的给药剂量是 10 mg/kg ，每只动物体重 20 g ，给药体积 100 μL ， 
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