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Anti-RUNX1/RUNX2/RUNX3/RUNX2/RUNX3 Antibody (4N296)
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产品编号 TMAC-03660
别名 Runx 1, Runt-related transcription factor 1, Polyomavirus enhancer-binding protein 2 alpha B subunit (PEA2-alpha B, PEBP2-α B), PEA2-alpha B, Oncogene AML-1, Core-binding factor subunit α-2 (CBF-α-2), Core-binding factor subunit alpha-2 (CBF-alpha-2), Core-binding factor subunit a-2 (CBF-a-2), Cbfa 2, Acute myeloid leukemia 1 protein
Anti-RUNX1/RUNX2/RUNX3 Antibody (4N296) 是一种 Rabbit 抗体，靶向 RUNX1/RUNX2/RUNX3。Anti-RUNX1/RUNX2/RUNX3 Antibody (4N296) 可用于 WB,ICC/IF,IHC,IP,FCM。
Anti-RUNX1/RUNX2/RUNX3/RUNX2/RUNX3 Antibody (4N296)
Anti-RUNX1/RUNX2/RUNX3/RUNX2/RUNX3 Antibody (4N296)
还可以产品编号 TMAC-03660 别名 Runx 1, Runt-related transcription factor 1, Polyomavirus enhancer-binding protein 2 alpha B subunit (PEA2-alpha B, PEBP2-α B), PEA2-alpha B, Oncogene AML-1, Core-binding factor subunit α-2 (CBF-α-2), Core-binding factor subunit alpha-2 (CBF-alpha-2), Core-binding factor subunit a-2 (CBF-a-2), Cbfa 2, Acute myeloid leukemia 1 protein
Anti-RUNX1/RUNX2/RUNX3 Antibody (4N296) 是一种 Rabbit 抗体，靶向 RUNX1/RUNX2/RUNX3。Anti-RUNX1/RUNX2/RUNX3 Antibody (4N296) 可用于 WB,ICC/IF,IHC,IP,FCM。
| 规格 | 价格 | 库存 | 数量 |
|---|---|---|---|
| 50 μL | ¥ 1,490 | 5日内发货 | |
| 100 μL | ¥ 2,490 | 5日内发货 |
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| 产品描述 | Anti-RUNX1/RUNX2/RUNX3 Antibody (4N296) is a Rabbit antibody targeting RUNX1/RUNX2/RUNX3. Anti-RUNX1/RUNX2/RUNX3 Antibody (4N296) can be used in WB,ICC/IF,IHC,IP,FCM. |
| 别名 | Runx 1, Runt-related transcription factor 1, Polyomavirus enhancer-binding protein 2 alpha B subunit (PEA2-alpha B, PEBP2-α B), PEA2-alpha B, Oncogene AML-1, Core-binding factor subunit α-2 (CBF-α-2), Core-binding factor subunit alpha-2 (CBF-alpha-2), Core-binding factor subunit a-2 (CBF-a-2), Cbfa 2, Acute myeloid leukemia 1 protein |
| Ig Type | IgG |
| 交叉反应 | Human,Mouse,Rat |
| 验证活性 | 1. Western blot analysis of RUNX1+RUNX2+RUNX3 on Jurkat cells lysates using anti-RUNX1+RUNX2+RUNX3 antibody at 1/1,000 dilution. 2. Immunohistochemical analysis of paraffin-embedded mouse testis tissue using anti-RUNX1+RUNX2+RUNX3 antibody. Counter stained with hematoxylin. 3. Immunohistochemical analysis of paraffin-embedded human tonsil tissue using anti-RUNX1+RUNX2+RUNX3 antibody. Counter stained with hematoxylin. 4. ICC staining RUNX1+RUNX2+RUNX3 in N2A cells (green). The nuclear counter stain is DAPI (blue). Cells were fixed in paraformaldehyde, permeabilised with 0.25% Triton X100/PBS. 5. ICC staining RUNX1+RUNX2+RUNX3 in MCF-7 cells (green). The nuclear counter stain is DAPI (blue). Cells were fixed in paraformaldehyde, permeabilised with 0.25% Triton X100/PBS. 6. ICC staining RUNX1+RUNX2+RUNX3 in SHG-44 cells (green). The nuclear counter stain is DAPI (blue). Cells were fixed in paraformaldehyde, permeabilised with 0.25% Triton X100/PBS. 7. Flow cytometric analysis of Jurkat cells with RUNX1+RUNX2+RUNX3 antibody at 1/50 dilution (red) compared with an unlabelled control (cells without incubation with primary antibody; black). Alexa Fluor 488-conjugated goat anti rabbit IgG was used as the secondary antibody. |
| 应用 | |
| 推荐剂量 | WB: 1:1000-2000; IHC: 1:50-200; ICC/IF: 1:50-200; FCM: 1:50-100 |
| 抗体种类 | Monoclonal |
| 宿主来源 | Rabbit |
| 构建方式 | Recombinant Antibody |
| 纯化方式 | ProA affinity purified |
| 性状 | Liquid |
| 缓冲液 | 1*TBS (pH7.4), 1%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide. |
| 研究背景 | The mammalian Runt-related transcription factor (RUNX) family comprises three members, RUNX1 (also designated AML-1, PEBP2αB, CBFA2), RUNX2 (also designated AML-3, PEBP2αA, CBFA1, Osf2) and RUNX3 (also designated AML-2, PEBPαC, CBFA3). RUNX family members are DNA-binding proteins that regulate the expression of genes involved in cellular differentiation and cell cycle progression. RUNX1 is involved in hematopoiesis and is frequently targeted in human leukemia by chromosomal translocations that fuse the DNA-binding domain of RUNX1 to other transcription factors and corepressor molecules. In addition to its role in leukemogenesis, RUNX1 is also involved in sensory neuron diversification. RUNX1 promotes axonal growth, is selectively expressed in neural crest-derived TrkA+ sensory neurons and mediates TrkA transactivation in migratory neural crest cells. RUNX2 is essential for skeletal mineralization in that it stimulates osteoblast differentiation of mesenchymal stem cells, promotes chondrocyte hypertrophy and contributes to endothelial cell migration and vascular invasion of developing bones. Regulating RUNX2 expression may be a useful therapeutic tool for promoting bone formation. Mutations in the C-terminus of RUNX2 are associated with cleidocranial dysplasia syndrome, an autosomal-dominant skeletal dysplasia syndrome that is characterized by widely patent calvarial sutures, clavicular hypoplasia, supernumerary teeth, and short stature. RUNX3 is expressed in cells of hematopoietic origin, including myeloid and B-cell lines and spleen. By playing a role in controlling the growth and differentiation of gastric epithelial cells, RUNX3 is a strong candidate as a gastric cancer tumor suppressor. Specifically, hypermethylation inactivates the gene encoding RUNX3. The detection of hypermethylation at multiple regions within the RUNX3 CpG island may aid in the diagnosis and risk assessment of gastric cancer. |
| 偶联 | Unconjugated |
| 免疫原 | Recombinant Protein |
| Uniprot ID |
| 分子量 | Theoretical: 49 kDa. |
存储&运输
| 储存方式 | Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. |
| 运输方式 | Shipping with blue ice. |
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