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顶部生物活性储存和溶解信息计算器

Anti-Phospho-RAF1 (Ser621) Polyclonal Antibody

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产品编号 TMAC-00956

别名 RAF1 (p-Ser621), RAF1 (p-S621), p-RAF1 (Ser621), p-RAF1 (S621), Phospho-RAF1 (S621)

Anti-Phospho-RAF1 (Ser621) Polyclonal Antibody 是一种 Rabbit 抗体，靶向 Phospho-RAF1 (Ser621)。Anti-Phospho-RAF1 (Ser621) Polyclonal Antibody 可用于 WB。

Anti-Phospho-RAF1 (Ser621) Polyclonal Antibody

Anti-Phospho-RAF1 (Ser621) Polyclonal Antibody

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Rating icon 还可以
产品编号 TMAC-00956 别名 RAF1 (p-Ser621), RAF1 (p-S621), p-RAF1 (Ser621), p-RAF1 (S621), Phospho-RAF1 (S621)

Anti-Phospho-RAF1 (Ser621) Polyclonal Antibody 是一种 Rabbit 抗体，靶向 Phospho-RAF1 (Ser621)。Anti-Phospho-RAF1 (Ser621) Polyclonal Antibody 可用于 WB。

规格价格库存数量
50 μL
¥ 1,495
5日内发货
100 μL
¥ 2,230
5日内发货
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产品介绍

生物活性
产品描述
Anti-Phospho-RAF1 (Ser621) Polyclonal Antibody is a Rabbit antibody targeting Phospho-RAF1 (Ser621). Anti-Phospho-RAF1 (Ser621) Polyclonal Antibody can be used in WB.
别名RAF1 (p-Ser621), RAF1 (p-S621), p-RAF1 (Ser621), p-RAF1 (S621), Phospho-RAF1 (S621)
Ig Type
IgG
交叉反应
Human,Mouse,Rat
验证活性
1. Western blot analysis of extracts from Hela cells treated with UV using C-RAF (Phospho-Ser621) Antibody TMAC-00956. The lane on the left is treated with the antigen-specific peptide.
verifiedActivity
应用WB
抗体种类
Polyclonal
宿主来源Rabbit
构建方式Polyclonal Antibody
纯化方式Antibodies were produced by immunizing rabbits with synthetic phosphopeptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific phosphopeptide. Non-phospho specific antibodies were removed by chromatogramphy using non-phosphopeptide.
性状Liquid
缓冲液Supplied at 1.0mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
研究背景Serine/threonine-protein kinase that acts as a regulatory link between the membrane-associated Ras GTPases and the MAPK/ERK cascade, and this critical regulatory link functions as a switch determining cell fate decisions including proliferation, differentiation, apoptosis, survival and oncogenic transformation. RAF1 activation initiates a mitogen-activated protein kinase (MAPK) cascade that comprises a sequential phosphorylation of the dual-specific MAPK kinases (MAP2K1/MEK1 and MAP2K2/MEK2) and the extracellular signal-regulated kinases (MAPK3/ERK1 and MAPK1/ERK2). The phosphorylated form of RAF1 (on residues Ser-338 and Ser-339, by PAK1) phosphorylates BAD/Bcl2-antagonist of cell death at 'Ser-75'. Phosphorylates adenylyl cyclases: ADCY2, ADCY5 and ADCY6, resulting in their activation. Phosphorylates PPP1R12A resulting in inhibition of the phosphatase activity. Phosphorylates TNNT2/cardiac muscle troponin T. Can promote NF-kB activation and inhibit signal transducers involved in motility (ROCK2), apoptosis (MAP3K5/ASK1 and STK3/MST2), proliferation and angiogenesis (RB1). Can protect cells from apoptosis also by translocating to the mitochondria where it binds BCL2 and displaces BAD/Bcl2-antagonist of cell death. Regulates Rho signaling and migration, and is required for normal wound healing. Plays a role in the oncogenic transformation of epithelial cells via repression of the TJ protein, occludin (OCLN) by inducing the up-regulation of a transcriptional repressor SNAI2/SLUG, which induces down-regulation of OCLN. Restricts caspase activation in response to selected stimuli, notably Fas stimulation, pathogen-mediated macrophage apoptosis, and erythroid differentiation.
偶联与修饰
偶联
Unconjugated
其他可选修饰符
Phospho
抗原信息
免疫原
Peptide sequence around phosphorylation site of Serine 621 (S-A-S(p)-E-P) derived from Human C-RAF
抗原种属
human
Uniprot ID
P04049
化学信息
分子量Actual: 74 kDa.
存储&运输
储存方式Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles.
运输方式Shipping with blue ice.

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关键词

RAF1 (pSer621)RAF1 (pS621)RAF1 (phospho-Ser621)RAF1 (phospho-S621)Raf-1RAF1RAF proto-oncogene serine/threonine-protein kinaseRAF 1RAFProto-oncogene c-RAF (cRaf)pRAF1 (Ser621)pRAF1 (S621)c-RafcRaf

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