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ONC-841 是一种针对唾液酸结合免疫球蛋白样凝集素 10 (Siglec-10) 的人源化单克隆抗体。Siglec-10 是一种表达在巨噬细胞表面的抑制性受体,通过结合肿瘤细胞表面的 CD24 分子触发“别吃我 (Don't eat me)”信号,从而抑制巨噬细胞的吞噬作用。ONC-841 通过特异性结合 Siglec-10,阻断 CD24-Siglec-10 相互作用,从而解除免疫抑制,增强巨噬细胞对肿瘤细胞的吞噬和清除能力。该抗体在针对 CD24 高表达的实体肿瘤(如卵巢癌和乳腺癌)的免疫疗法研究中具有显著意义。
ONC-841 是一种针对唾液酸结合免疫球蛋白样凝集素 10 (Siglec-10) 的人源化单克隆抗体。Siglec-10 是一种表达在巨噬细胞表面的抑制性受体,通过结合肿瘤细胞表面的 CD24 分子触发“别吃我 (Don't eat me)”信号,从而抑制巨噬细胞的吞噬作用。ONC-841 通过特异性结合 Siglec-10,阻断 CD24-Siglec-10 相互作用,从而解除免疫抑制,增强巨噬细胞对肿瘤细胞的吞噬和清除能力。该抗体在针对 CD24 高表达的实体肿瘤(如卵巢癌和乳腺癌)的免疫疗法研究中具有显著意义。
| 规格 | 价格 | 库存 | 数量 |
|---|---|---|---|
| 1 mg | ¥ 12,000 | 待询 | |
| 5 mg | 待询 | 待询 |
| 产品描述 | ONC-841 is a humanized monoclonal antibody targeting Sialic acid-binding Ig-like lectin 10 (Siglec-10). Siglec-10 is an inhibitory receptor expressed on the surface of macrophages that triggers a "don't eat me" signal upon binding to CD24 on tumor cells, thereby inhibiting phagocytosis. ONC-841 specifically binds to Siglec-10 and blocks the CD24-Siglec-10 interaction, alleviating immune suppression and enhancing the phagocytic clearance of tumor cells by macrophages. This antibody is significant for immunotherapy research in solid tumors with high CD24 expression, such as ovarian and breast cancers. |
| 反应种属 | Human |
| 应用 | ELISA FACS Functional assay |
| 抗体种类 | Monoclonal |
| 缓冲液 | Supplied as a sterile solution in a buffered formulation system (e.g., phosphate-, citrate-, or amino acid-based). Please refer to the CoA for lot-specific composition. |
| 内毒素 | <1.0 EU/mg |
| 同型 | IgG4SP-opti |
| 偶联 | Unconjugated |
| Uniprot ID | |
| 靶点 | Siglec-10 |
| 存储 | store at low temperature | -20°C for 2 years, 4°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. |
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