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Anti-Nicastrin Antibody-PE (4B647)
还可以产品编号 TMAY-01719P
Anti-Nicastrin Antibody-PE (4B647) 是一种 PE-conjugated Rabbit 抗体，靶向 Nicastrin。Anti-Nicastrin Antibody-PE (4B647) 可用于 FCM。
Anti-Nicastrin Antibody-PE (4B647)
Anti-Nicastrin Antibody-PE (4B647)
还可以产品编号 TMAY-01719P
Anti-Nicastrin Antibody-PE (4B647) 是一种 PE-conjugated Rabbit 抗体，靶向 Nicastrin。Anti-Nicastrin Antibody-PE (4B647) 可用于 FCM。
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偶联与修饰
抗原信息
| 产品描述 | Anti-Nicastrin Antibody-PE (4B647) is a PE-conjugated Rabbit antibody targeting Nicastrin. Anti-Nicastrin Antibody-PE (4B647) can be used in FCM. |
| Ig Type | Monoclonal Rabbit IgG |
| 克隆号 | 4B647 |
| 交叉反应 | Human |
| 验证活性 | Flow cytometric analysis of NCSTN on HepG2 cells. |
| 应用 | FCM |
| 推荐剂量 | 10 μl/Test, 0.1 mg/ml |
| 抗体种类 | Monoclonal |
| 宿主来源 | Rabbit |
| 构建方式 | This antibody was obtained from a rabbit immunized with purified, recombinant Human Nicastrin / NCSTN (rh Nicastrin / NCSTN; TMPY-01297; NP_056146.1; Met1-Glu669) and conjugated with PE under optimum conditions, the unreacted PE was removed. |
| 纯化方式 | Protein A |
| 性状 | Liquid |
| 缓冲液 | PBS solution containing 0.5% BSA and 0.03%ProClin300 |
| 研究背景 | Nicastrin (NCST, or NCT), a single-pass membrane glycoprotein that harbors a large extracellular domain, is an essential component of the gamma-secretase complex. Several lines of evidence indicate that the members of these complexes could also contribute to the control of cell death. NCT controls cell death via phosphoinositide 3-kinase/Akt and p53-dependent pathways and that this function remains independent of the activity and molecular integrity of the gamma-secretase complexes. Increasing pieces of evidence have shown that Nicastrin/NCSTN plays a crucial role in gamma-cleavage of the amyloid precursor protein (APP). The glycoprotein Nicastrin is an essential component of the gamma-secretase complex, a high molecular weight complex that also contains the presenilin proteins, Aph-1 and Pen-2. The gamma-secretase complex is not only involved in APP processing but also in the processing of an increasing number of another type I integral membrane proteins. As the largest subunit of the gamma-secretase complex, Nicastrin plays a crucial role in its activation. Inhibition of NCSTN demonstrated an altered gamma-cleavage activity, suggesting its potential implication in developing Alzheimer's disease (AD). Besides, Nicastrin can function to maintain epithelial to mesenchymal transition during breast cancer progression. Anti-nicastrin polyclonal and monoclonal antibodies were able to decrease notch1 and vimentin expression and reduced the invasive capacity of breast cancer cells in vitro. |
| 偶联 | PE |
| 其他可选修饰符 | Unconjugated/FITC |
| 可提供抗体种类 | 3 |
| 免疫原 | Recombinant Human Nicastrin / NCSTN protein (TMPY-01297) |
| 抗原种属 | Human |
存储&运输
| 储存方式 | Store at 2°C-8°C for 12 months, do not freeze. Keep away from direct sunlight. |
| 运输方式 | Shipping with blue ice. |
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计算器
比如您的给药剂量是 10 mg/kg ，每只动物体重 20 g ，给药体积 100 μL ， 
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