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ZNRF3 Protein, Human, Recombinant (His)

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货号 TMPH-01275

别名 ZNRF3, Zinc/RING finger protein 3, RNF203, RING-type E3 ubiquitin transferase ZNRF3, RING finger protein 203, KIAA1133, E3 ubiquitin-protein ligase ZNRF3

E3 ubiquitin-protein ligase that acts as a negative regulator of the Wnt signaling pathway by mediating the ubiquitination and subsequent degradation of Wnt receptor complex components Frizzled and LRP6. Acts on both canonical and non-canonical Wnt signaling pathway. Acts as a tumor suppressor in the intestinal stem cell zone by inhibiting the Wnt signaling pathway, thereby resticting the size of the intestinal stem cell zone. Along with RSPO2 and RNF43, constitutes a master switch that governs limb specification.

ZNRF3 Protein, Human, Recombinant (His)
其他形式的 “ZNRF3 Protein, Human, Recombinant (His)”:
ZNRF3 Protein, Human, Recombinant (His & SUMO)TMPH-01274
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ZNRF3 Protein, Human, Recombinant (His)

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货号 TMPH-01275 别名 ZNRF3, Zinc/RING finger protein 3, RNF203, RING-type E3 ubiquitin transferase ZNRF3, RING finger protein 203, KIAA1133, E3 ubiquitin-protein ligase ZNRF3

E3 ubiquitin-protein ligase that acts as a negative regulator of the Wnt signaling pathway by mediating the ubiquitination and subsequent degradation of Wnt receptor complex components Frizzled and LRP6. Acts on both canonical and non-canonical Wnt signaling pathway. Acts as a tumor suppressor in the intestinal stem cell zone by inhibiting the Wnt signaling pathway, thereby resticting the size of the intestinal stem cell zone. Along with RSPO2 and RNF43, constitutes a master switch that governs limb specification.

规格价格库存数量
5 μg
¥ 397
20日内发货
10 μg
¥ 662
20日内发货
20 μg
¥ 1,090
20日内发货
50 μg
¥ 1,680
20日内发货
100 μg
¥ 2,390
20日内发货
200 μg
¥ 4,380
20日内发货
500 μg
¥ 9,830
20日内发货
1 mg
¥ 18,200
20日内发货
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产品介绍

生物活性
产品描述
E3 ubiquitin-protein ligase that acts as a negative regulator of the Wnt signaling pathway by mediating the ubiquitination and subsequent degradation of Wnt receptor complex components Frizzled and LRP6. Acts on both canonical and non-canonical Wnt signaling pathway. Acts as a tumor suppressor in the intestinal stem cell zone by inhibiting the Wnt signaling pathway, thereby resticting the size of the intestinal stem cell zone. Along with RSPO2 and RNF43, constitutes a master switch that governs limb specification.
生物活性
Measured by its binding ability in a functional ELISA. Immobilized Human ZNRF3 at 5 μg/mL can bind Human RSPO2, the EC 50 is 5.091-6.991 ng/mL.
研究背景
E3 ubiquitin-protein ligase that acts as a negative regulator of the Wnt signaling pathway by mediating the ubiquitination and subsequent degradation of Wnt receptor complex components Frizzled and LRP6. Acts on both canonical and non-canonical Wnt signaling pathway. Acts as a tumor suppressor in the intestinal stem cell zone by inhibiting the Wnt signaling pathway, thereby resticting the size of the intestinal stem cell zone. Along with RSPO2 and RNF43, constitutes a master switch that governs limb specification.
种属
Human
表达系统
HEK293 Cells
标签C-6xHis
蛋白编号Q9ULT6
氨基酸序列KETAFVEVVLFESSPSGDYTTYTTGLTGRFSRAGATLSAEGEIVQMHPLGLCNNNDEEDLYEYGWVGVVKLEQPELDPKPCLTVLGKAKRAVQRGATAVIFDVSENPEAIDQLNQGSEDPLKRPVVYVKGADAIKLMNIVNKQKVARARIQHRPPRQPTEYFDM
蛋白构建56-219 aa
蛋白纯度
> 95% as determined by SDS-PAGE.
缓冲液Lyophilized from a solution filtered through a 0.22 μm filter, containing PBS, 6% Trehalose, pH 7.4
复溶方法Reconstitute the lyophilized protein in sterile deionized water. The product concentration should not be less than 100 μg/mL. Before opening, centrifuge the tube to collect powder at the bottom. After adding the reconstitution buffer, avoid vortexing or pipetting for mixing.
别名ZNRF3, Zinc/RING finger protein 3, RNF203, RING-type E3 ubiquitin transferase ZNRF3, RING finger protein 203, KIAA1133, E3 ubiquitin-protein ligase ZNRF3
内毒素< 1.0 EU/μg of the protein as determined by the LAL method.
化学信息
分子量20.4 kDa (predicted)
储存&溶解度
运输方式In general, Lyophilized powders are shipping with blue ice. Solutions are shipping with dry ice.
存储Lyophilized powders can be stably stored for over 12 months, while liquid products can be stored for 6-12 months at -80°C. For reconstituted protein solutions, the solution can be stored at -20°C to -80°C for at least 3 months. Please avoid multiple freeze-thaw cycles and store products in aliquots.

计算器

  • 复溶 计算器
  • 重组蛋白稀释 计算器
  • 比活力 计算器

剂量转换

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技术支持

请阅读 重组蛋白用户指南 了解更多具体信息.

关键词

ZNRF 3RNF 203KIAA-1133
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