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Anti-MDM2 Polyclonal Antibody

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Anti-MDM2 Polyclonal Antibody
产品编号 TMAB-01124
别名 RING-type E3 ubiquitin transferase Mdm2, p53-binding protein Mdm2, Oncoprotein Mdm2, Mdm2, E3 ubiquitin-protein ligase Mdm2, Double minute 2 protein

Anti-MDM2 Polyclonal Antibody 是一种 Rabbit 抗体，靶向 MDM2。Anti-MDM2 Polyclonal Antibody 可用于 IHC-P,IHC-Fr,IF。

Anti-MDM2 Polyclonal Antibody

Anti-MDM2 Polyclonal Antibody

Rating icon 还可以
Anti-MDM2 Polyclonal Antibody
产品编号 TMAB-01124 别名 RING-type E3 ubiquitin transferase Mdm2, p53-binding protein Mdm2, Oncoprotein Mdm2, Mdm2, E3 ubiquitin-protein ligase Mdm2, Double minute 2 protein

Anti-MDM2 Polyclonal Antibody 是一种 Rabbit 抗体，靶向 MDM2。Anti-MDM2 Polyclonal Antibody 可用于 IHC-P,IHC-Fr,IF。

规格价格库存数量
50 μL
¥ 1,160
5日内发货
100 μL
¥ 1,965
5日内发货
200 μL
¥ 2,785
5日内发货
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生物活性
产品描述
Anti-MDM2 Polyclonal Antibody is a Rabbit antibody targeting MDM2. Anti-MDM2 Polyclonal Antibody can be used in IHC-P,IHC-Fr,IF.
别名RING-type E3 ubiquitin transferase Mdm2, p53-binding protein Mdm2, Oncoprotein Mdm2, Mdm2, E3 ubiquitin-protein ligase Mdm2, Double minute 2 protein
Ig Type
IgG
交叉反应
Human,Mouse (predicted:Rat,Dog,Pig)
验证活性
1. Paraformaldehyde-fixed, paraffin embedded (Human brain glioma); Antigen retrieval by boiling in sodium citrate buffer (pH6.0) for 15 min; Block endogenous peroxidase by 3% hydrogen peroxide for 20 min; Blocking buffer (normal goat serum) at 37°C for 30 min; Antibody incubation with (MDM2) Polyclonal Antibody, Unconjugated (TMAB-01124) at 1:400 overnight at 4°C, followed by operating according to SP Kit (Rabbit) instructionsand DAB staining.
2. Paraformaldehyde-fixed, paraffin embedded (Mouse brain); Antigen retrieval by boiling in sodium citrate buffer (pH6.0) for 15 min; Block endogenous peroxidase by 3% hydrogen peroxide for 20 min; Blocking buffer (normal goat serum) at 37°C for 30 min; Antibody incubation with (MDM2) Polyclonal Antibody, Unconjugated (TMAB-01124) at 1:400 overnight at 4°C, followed by operating according to SP Kit (Rabbit) instructionsand DAB staining.
3. Paraformaldehyde-fixed, paraffin embedded (Human breast carcinoma); Antigen retrieval by boiling in sodium citrate buffer (pH6.0) for 15 min; Block endogenous peroxidase by 3% hydrogen peroxide for 20 min; Blocking buffer (normal goat serum) at 37°C for 30 min; Antibody incubation with (MDM2) Polyclonal Antibody, Unconjugated (TMAB-01124) at 1:400 overnight at 4°C, followed by operating according to SP Kit (Rabbit) instructionsand DAB staining.
4. Paraformaldehyde-fixed, paraffin embedded (mouse brain tissue); Antigen retrieval by boiling in sodium citrate buffer (pH6.0) for 15 min; Block endogenous peroxidase by 3% hydrogen peroxide for 20 min; Blocking buffer (normal goat serum) at 37°C for 30 min; Antibody incubation with (MDM2) Polyclonal Antibody, Unconjugated (TMAB-01124) at 1:400 overnight at 4°C, followed by operating according to SP Kit (Rabbit) instructionsand DAB staining.
应用
IHC-P
IHC-Fr
IF
推荐剂量
IHC-P: 1:100-500; IHC-Fr: 1:100-500; IF: 1:100-500
抗体种类
Polyclonal
宿主来源Rabbit
亚细胞定位Nucleus, nucleoplasm. Cytoplasm. Nucleus, nucleolus. Expressed predominantly in the nucleoplasm. Interaction with ARF(P14) results in the localization of both proteins to the nucleolus. The nucleolar localization signals in both ARF(P14) and MDM2 may be necessary to allow efficient nucleolar localization of both proteins. Colocalizes with RASSF1 isoform A in the nucleus.
构建方式Polyclonal Antibody
纯化方式Protein A purified
性状Liquid
缓冲液0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
研究背景Inhibits TP53/p53- and TP73/p73-mediated cell cyclearrest and apoptosis by binding its transcriptional activation domain. Functions as a ubiquitin ligase E3, in the presence of E1 and E2, toward p53 and itself. Permits the nuclear export of p53 and targets it for proteasome-mediated proteolysis. Binds p53, p73, ARF(P14), ribosomal protein L5 and specifically to RNA. Can interact also with retinoblastoma protein(RB), E1A-associated protein EP300 and the E2F1 transcription factor. Forms a ternary complex with TP53/p53 and WWOX. Interacts with CDKN2AIP, MTBP, TRBG1 and USP7. Isoform Mdm2-F does not interact with TP53/p53. Interacts with PYHIN1. Interacts with, and ubiquitinates HIV-1 Tat. Belongs to the MDM2/MDM4 family.
抗原信息
免疫原
KLH conjugated synthetic peptide: human MDM2
抗原种属
Human
基因ID
4193
Uniprot ID
Q00987
研究领域
p53 pathway,Cell survival & death,p53,ChIP antibodies,Other factors,E3 Ubiquitin Ligases
化学信息
分子量Theoretical: 55 kDa.
存储&运输
储存方式Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles.
运输方式Shipping with blue ice.

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关键词

Oncoprotein Mdm 2Mdm 2

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