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Anti-Alpha-Synuclein Antibody (1Q928)
还可以产品编号 TMAY-02234
Anti-Alpha-Synuclein Antibody (1Q928) 是一种 Rabbit 抗体，靶向 Alpha-Synuclein。Anti-Alpha-Synuclein Antibody (1Q928) 可用于 WB,ELISA。
Anti-Alpha-Synuclein Antibody (1Q928)
Anti-Alpha-Synuclein Antibody (1Q928)
还可以产品编号 TMAY-02234
Anti-Alpha-Synuclein Antibody (1Q928) 是一种 Rabbit 抗体，靶向 Alpha-Synuclein。Anti-Alpha-Synuclein Antibody (1Q928) 可用于 WB,ELISA。
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抗原信息
| 产品描述 | Anti-Alpha-Synuclein Antibody (1Q928) is a Rabbit antibody targeting Alpha-Synuclein. Anti-Alpha-Synuclein Antibody (1Q928) can be used in WB,ELISA. |
| Ig Type | Monoclonal Rabbit IgG |
| 克隆号 | 1Q928 |
| 交叉反应 | Human |
| 验证活性 | 1. Anti-SNCA rabbit monoclonal antibody at 1:500 dilution. -Lane A: 293T Whole Cell lysate. -Lysates/proteins at 30 μg per lane. -Secondary -Goat Anti-Rabbit IgG H&L (Dylight800) at 1/10000 dilution. -Developed using the Odyssey technique. -Performed under reducing conditions. -Predicted band size:16 kDa. -Observed band size:18 kDa. 2. Anti-alpha-Synuclein rabbit monoclonal antibody at 1:500 dilution. -Lane A: Hela Whole Cell Lysate. -Lane B: alpha-Synuclein konckout Hela Whole Cell lysate. -Lysates/proteins at 30 μg per lane. -Secondary -Goat Anti-Rabbit IgG (H+L)/HRP at 1/10000 dilution. -Developed using the ECL technique. -Performed under reducing conditions. -Predicted band size:14 kDa. -Observed band size:16 kDa(Validation Experiment) |
| 应用 | WB,ELISA |
| 推荐剂量 | WB: 1:500-1:2000; ELISA: 1:5000-1:10000 |
| 抗体种类 | Monoclonal |
| 宿主来源 | Rabbit |
| 构建方式 | This antibody was obtained from a rabbit immunized with purified, recombinant Human SNCA / alpha-Synuclein (rh SNCA / alpha-Synuclein; TMPY-02512; P37840-1; Met1-Ala140). |
| 纯化方式 | Protein A |
| 性状 | Liquid |
| 缓冲液 | 0.2 μm filtered solution in PBS |
| 研究背景 | Alpha-Synuclein (alpha-Syn), also known as NACP or SNCA, exists as at least two structural isoforms: one is helix-rich, membrane-bound form that both the N- and C-terminal regions of alpha-synuclein are tightly associated with membranes and the other is disordered, cytosolic form. Synuclein is found predominantly in the presynaptic termini, in both free or membrane-bound forms. SNCA is extensively localized in nucleus of neurons. It has been shown that alpha-Synuclein was highly expressed in the mitochondria in olfactory bulb, hippocampus, striatum, and thalamus, where the cytosolic alpha-Synuclein was also rich. Normally the unstructured soluble type of alpha-synuclein can aggregate to form insoluble fibrils in pathological conditions characterized by Lewy bodies, such as Parkinson's disease, dementia with Lewy bodies and multiple system atrophy. SNCA abnormality and mitochondrial deficiency are two major changes in the brain of patients with Parkinson's disease (PD). Besides, alpha-synuclein is an abundant component of Lewy bodies in sporadic Parkinson's disease and diffuse Lewy body disease. |
| 偶联 | Unconjugated |
| 免疫原 | Recombinant Human SNCA / alpha-Synuclein protein (TMPY-02512) |
| 抗原种属 | Human |
存储&运输
| 储存方式 | Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. Preservative-Free. |
| 运输方式 | Shipping with blue ice. |
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比如您的给药剂量是 10 mg/kg ，每只动物体重 20 g ，给药体积 100 μL ， 
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