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顶部生物活性储存和溶解信息计算器

Anti-Shc Antibody (2E265)

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Anti-Shc Antibody (2E265)
产品编号 TMAC-03736
别名 Src homology 2 domain-containing-transforming protein C1, SHC-transforming protein A, SHC-transforming protein 3, SHC-transforming protein 1, SHCA, SHC1_HUMAN, SHC1, SHC transforming protein 1, SHC transforming protein, SHC adaptor protein 1, SHC A, SHC 1, SHC (Src homology 2 domain containing) transforming protein 1, Shc, SH2 domain protein C1, p66SHC, p66, FLJ26504

Anti-Shc Antibody (2E265) 是一种 Mouse 抗体，靶向 Shc。Anti-Shc Antibody (2E265) 可用于 WB,ICC,FCM。

Anti-Shc Antibody (2E265)

Anti-Shc Antibody (2E265)

Rating icon 还可以
Anti-Shc Antibody (2E265)
产品编号 TMAC-03736 别名 Src homology 2 domain-containing-transforming protein C1, SHC-transforming protein A, SHC-transforming protein 3, SHC-transforming protein 1, SHCA, SHC1_HUMAN, SHC1, SHC transforming protein 1, SHC transforming protein, SHC adaptor protein 1, SHC A, SHC 1, SHC (Src homology 2 domain containing) transforming protein 1, Shc, SH2 domain protein C1, p66SHC, p66, FLJ26504

Anti-Shc Antibody (2E265) 是一种 Mouse 抗体，靶向 Shc。Anti-Shc Antibody (2E265) 可用于 WB,ICC,FCM。

规格价格库存数量
50 μL
¥ 1,985
5日内发货
100 μL
¥ 2,985
5日内发货
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产品介绍

生物活性
产品描述
Anti-Shc Antibody (2E265) is a Mouse antibody targeting Shc. Anti-Shc Antibody (2E265) can be used in WB,ICC,FCM.
别名Src homology 2 domain-containing-transforming protein C1, SHC-transforming protein A, SHC-transforming protein 3, SHC-transforming protein 1, SHCA, SHC1_HUMAN, SHC1, SHC transforming protein 1, SHC transforming protein, SHC adaptor protein 1, SHC A, SHC 1, SHC (Src homology 2 domain containing) transforming protein 1, Shc, SH2 domain protein C1, p66SHC, p66, FLJ26504
交叉反应
Human,Mouse
验证活性
1. Western blot analysis of SHC1 on human SHC1 recombinant protein using anti-SHC1 antibody at 1/1,000 dilution.
2. Western blot analysis of SHC1 on HEK293 (1) and SHC1-hIgGFc transfected HEK293 (2) cell lysate using anti-SHC1 antibody at 1/1,000 dilution.
3. Western blot analysis of SHC1 on NIH/3T3?cell lysate using anti-SHC1 antibody at 1/1,000 dilution.
4. ICC staining SHC1 (green) and Actin filaments (red) in A431 cells. The nuclear counter stain is DAPI (blue). Cells were fixed in paraformaldehyde, permeabilised with 0.25% Triton X100/PBS.
5. Flow cytometric analysis of NIH/3T3 cells with SHC1 antibody at 1/100 dilution (green) compared with an unlabelled control (cells without incubation with primary antibody; red).
应用
WB
ICC
FCM
推荐剂量
WB: 1:500-2000; IHC: 1:50-200; ICC: 1:50-200; FCM: 1:50-100
抗体种类
Monoclonal
宿主来源Mouse
构建方式Hybridoma Monoclonal Antibody
纯化方式ProA affinity purified
性状Liquid
缓冲液1*TBS (pH7.4), 1%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide.
研究背景Growth factor triggering of protein tyrosine kinase receptors induces signals that cascade to the nucleus activating mitogenic, as well as other, responses. Critical components of this process include adapter proteins such as Shc and IRS-1 that lack detectable catalytic activity. These are immediate substrates of receptor tyrosine kinase activity and serve to physically link activated receptors to downstream signaling components. Whereas Shc has been implicated in signaling by diverse receptor families, IRS-1 serves primarily as the major insulin receptor substrate (4-7). Shc also participates in insulin signaling by linking the insulin receptor to Ras by forming complexes with the adapter protein GRB2 and Sos independently of IRS-1. A protein immunologically related to IRS-1, originally designated 4PS and now known as IRS-2, was shown to become highly tyrosine phosphorylated in response to IL-4 or IGF-1 in cells lacking IRS-1. An additional member of this family of signaling intermediates, Shb, is a SH2-containing protein with characteristic proline-rich domains.
偶联与修饰
偶联
Unconjugated
抗原信息
免疫原
Recombinant Protein
Uniprot ID
P29353
化学信息
分子量Theoretical: 63 kDa.
存储&运输
储存方式Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles.
运输方式Shipping with blue ice.

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