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Anti-SET Antibody (3V307)
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产品编号 TMAC-03713
别名 Template-Activating Factor-I, chromatin remodelling factor, Template-activating factor I, Template activating factor I, TAF-I, TAFI, TAF IBETA, TAF I, SET_HUMAN, SET translocation (myeloid leukemia-associated), SET translocation, SET nuclear oncogene, Set, Protein SET, protein phosphatase type 2A inhibitor, Phosphatase 2A inhibitor I2PP2A, PHAPII, IPP2A2, inhibitor-2 of protein phosphatase-2A, Inhibitor of GzmA-activated DNase, Inhibitor of granzyme A-activated DNase, Inhibitor of granzyme A activated DNase, IGAAD, I-2PP2A, I2PP2A, I 2PP2A, HLA-DR-associated protein II, HLA DR associated protein II, 2PP2A
Anti-SET Antibody (3V307) 是一种 Rabbit 抗体，靶向 SET。Anti-SET Antibody (3V307) 可用于 WB,ICC,IF,IHC,IP,FCM。
Anti-SET Antibody (3V307)
Anti-SET Antibody (3V307)
还可以产品编号 TMAC-03713 别名 Template-Activating Factor-I, chromatin remodelling factor, Template-activating factor I, Template activating factor I, TAF-I, TAFI, TAF IBETA, TAF I, SET_HUMAN, SET translocation (myeloid leukemia-associated), SET translocation, SET nuclear oncogene, Set, Protein SET, protein phosphatase type 2A inhibitor, Phosphatase 2A inhibitor I2PP2A, PHAPII, IPP2A2, inhibitor-2 of protein phosphatase-2A, Inhibitor of GzmA-activated DNase, Inhibitor of granzyme A-activated DNase, Inhibitor of granzyme A activated DNase, IGAAD, I-2PP2A, I2PP2A, I 2PP2A, HLA-DR-associated protein II, HLA DR associated protein II, 2PP2A
Anti-SET Antibody (3V307) 是一种 Rabbit 抗体，靶向 SET。Anti-SET Antibody (3V307) 可用于 WB,ICC,IF,IHC,IP,FCM。
| 规格 | 价格 | 库存 | 数量 |
|---|---|---|---|
| 50 μL | ¥ 1,490 | 5日内发货 | |
| 100 μL | ¥ 2,485 | 5日内发货 |
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| 产品描述 | Anti-SET Antibody (3V307) is a Rabbit antibody targeting SET. Anti-SET Antibody (3V307) can be used in WB,ICC,IF,IHC,IP,FCM. |
| 别名 | Template-Activating Factor-I, chromatin remodelling factor, Template-activating factor I, Template activating factor I, TAF-I, TAFI, TAF IBETA, TAF I, SET_HUMAN, SET translocation (myeloid leukemia-associated), SET translocation, SET nuclear oncogene, Set, Protein SET, protein phosphatase type 2A inhibitor, Phosphatase 2A inhibitor I2PP2A, PHAPII, IPP2A2, inhibitor-2 of protein phosphatase-2A, Inhibitor of GzmA-activated DNase, Inhibitor of granzyme A-activated DNase, Inhibitor of granzyme A activated DNase, IGAAD, I-2PP2A, I2PP2A, I 2PP2A, HLA-DR-associated protein II, HLA DR associated protein II, 2PP2A |
| Ig Type | IgG |
| 交叉反应 | Human,Mouse,Rat |
| 验证活性 | 1. Western blot analysis of SET on K562 cell lysates using anti-SET at 1/500 dilution. 2. Immunohistochemical analysis of paraffin-embedded rat kidney tissue using anti-SET antibody. Counter stained with hematoxylin. 3. Immunohistochemical analysis of paraffin-embedded human tonsil tissue using anti-SET antibody. Counter stained with hematoxylin. 4. Immunohistochemical analysis of paraffin-embedded mouse fallopian tube tissue using anti-SET antibody. Counter stained with hematoxylin. 5. Immunohistochemical analysis of paraffin-embedded human lung cancer tissue using anti-SET antibody. Counter stained with hematoxylin. 6. Immunohistochemical analysis of paraffin-embedded human kidney tissue using anti-SET antibody. Counter stained with hematoxylin. 7. ICC staining SET in Hela cells (green). The nuclear counter stain is DAPI (blue). Cells were fixed in paraformaldehyde, permeabilised with 0.25% Triton X100/PBS. 8. ICC staining SET in LOVO cells (green). The nuclear counter stain is DAPI (blue). Cells were fixed in paraformaldehyde, permeabilised with 0.25% Triton X100/PBS. 9. ICC staining SET in MCF-7 cells (green). The nuclear counter stain is DAPI (blue). Cells were fixed in paraformaldehyde, permeabilised with 0.25% Triton X100/PBS. |
| 应用 | |
| 推荐剂量 | WB: 1:500-2000; IHC: 1:50-200; ICC: 1:50-200; IP: 1:10-50; FCM: 1:50-100 |
| 抗体种类 | Monoclonal |
| 宿主来源 | Rabbit |
| 构建方式 | Recombinant Antibody |
| 纯化方式 | ProA affinity purified |
| 性状 | Liquid |
| 缓冲液 | 1*TBS (pH7.4), 1%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide. |
| 研究背景 | Multitasking protein, involved in apoptosis, transcription, nucleosome assembly and histone chaperoning. Isoform 2 apoptotic activity is mediated by inhibition of the GZMA-activated DNase, NME1. In the course of cytotoxic T-lymphocyte (CTL)-induced apoptosis, GZMA cleaves SET, disrupting its binding to NME1 and releasing NME1 inhibition. Isoform 1 and isoform 2 are potent inhibitors of protein phosphatase 2A. Isoform 1 and isoform 2 inhibit EP300/CREBBP and PCAF-mediated acetylation of histones (HAT) and nucleosomes, most probably by masking the accessibility of lysines of histones to the acetylases. The predominant target for inhibition is histone H4. HAT inhibition leads to silencing of HAT-dependent transcription and prevents active demethylation of DNA. Both isoforms stimulate DNA replication of the adenovirus genome complexed with viral core proteins; however, isoform 2 specific activity is higher. |
| 偶联 | Unconjugated |
| 免疫原 | Recombinant Protein |
| Uniprot ID |
| 分子量 | Theoretical: 37 kDa. |
存储&运输
| 储存方式 | Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. |
| 运输方式 | Shipping with blue ice. |
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