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顶部生物活性储存和溶解信息计算器

Anti-BMAL1 Antibody (5D959)

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产品编号 TMAC-00453

别名 TIC, PASD3, PAS domain-containing protein 3, MOP3, Member of PAS protein 3, Class E basic helix-loop-helix protein 5(bHLHe5), Brain and muscle ARNT-like 1, BMAL1c, BMAL1, bHLH-PAS protein JAP3, BHLHE5, Basic-helix-loop-helix-PAS protein MOP3, Basic helix-loop-helix ARNT-like protein 1, Aryl hydrocarbon receptor nuclear translocator-like protein 1, ARNTL1, ARNTL

Anti-BMAL1 Antibody (5D959) 是一种 Rabbit 抗体，靶向 BMAL1。Anti-BMAL1 Antibody (5D959) 可用于 ICC/IF,WB。

Anti-BMAL1 Antibody (5D959)

Anti-BMAL1 Antibody (5D959)

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Rating icon 还可以
产品编号 TMAC-00453 别名 TIC, PASD3, PAS domain-containing protein 3, MOP3, Member of PAS protein 3, Class E basic helix-loop-helix protein 5(bHLHe5), Brain and muscle ARNT-like 1, BMAL1c, BMAL1, bHLH-PAS protein JAP3, BHLHE5, Basic-helix-loop-helix-PAS protein MOP3, Basic helix-loop-helix ARNT-like protein 1, Aryl hydrocarbon receptor nuclear translocator-like protein 1, ARNTL1, ARNTL

Anti-BMAL1 Antibody (5D959) 是一种 Rabbit 抗体，靶向 BMAL1。Anti-BMAL1 Antibody (5D959) 可用于 ICC/IF,WB。

规格价格库存数量
50 μL
¥ 1,490
5日内发货
100 μL
¥ 2,495
5日内发货
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产品介绍

生物活性
产品描述
Anti-BMAL1 Antibody (5D959) is a Rabbit antibody targeting BMAL1. Anti-BMAL1 Antibody (5D959) can be used in ICC/IF,WB.
别名TIC, PASD3, PAS domain-containing protein 3, MOP3, Member of PAS protein 3, Class E basic helix-loop-helix protein 5(bHLHe5), Brain and muscle ARNT-like 1, BMAL1c, BMAL1, bHLH-PAS protein JAP3, BHLHE5, Basic-helix-loop-helix-PAS protein MOP3, Basic helix-loop-helix ARNT-like protein 1, Aryl hydrocarbon receptor nuclear translocator-like protein 1, ARNTL1, ARNTL
Ig Type
IgG
克隆号
5D959
交叉反应
Human,Mouse,Rat
验证活性
1. Western blot analysis of BMAL1 on different lysates using anti-BMAL1 antibody at 1/1,000 dilution. Positive control: Lane 1: NIH/3T3, Lane 2: Rat brain, Lane 3: Mouse spleen, Lane 4: Hela.
2. ICC staining BMAL1 in Hela cells (green). The nuclear counter stain is DAPI (blue). Cells were fixed in paraformaldehyde, permeabilised with 0.25% Triton X100/PBS.
3. ICC staining BMAL1 in SH-SY5Y cells (green). The nuclear counter stain is DAPI (blue). Cells were fixed in paraformaldehyde, permeabilised with 0.25% Triton X100/PBS.
verifiedActivityverifiedActivityverifiedActivity
应用ICC/IFWB
推荐剂量
WB: 1:1000-2000; ICC/IF: 1:50-200
抗体种类
Monoclonal
宿主来源Rabbit
构建方式Recombinant Antibody
纯化方式ProA affinity purified
性状Liquid
缓冲液1*TBS (pH7.4), 1%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide.
研究背景Transcriptional activator which forms a core component of the circadian clock. Transcription factors, CLOCK or NPAS2 and ARNTL/BMAL1 or ARNTL2/BMAL2, form the positive limb of the feedback loop, act in the form of a heterodimer and activate the transcription of core clock genes and clock-controlled genes (involved in key metabolic processes), harboring E-box elements (5'-CACGTG-3') within their promoters. The core clock genes: PER1/2/3 and CRY1/2 which are transcriptional repressors form the negative limb of the feedback loop and interact with the CLOCK|NPAS2-ARNTL/BMAL1|ARNTL2/BMAL2 heterodimer inhibiting its activity and thereby negatively regulating their own expression. This heterodimer also activates nuclear receptors NR1D1/2 and RORA/B/G, which form a second feedback loop and which activate and repress ARNTL/BMAL1 transcription, respectively. ARNTL/BMAL1 positively regulates myogenesis and negatively regulates adipogenesis via the transcriptional control of the genes of the canonical Wnt signaling pathway.
偶联与修饰
偶联
Unconjugated
抗原信息
免疫原
Recombinant Protein
Uniprot ID
O00327
化学信息
分子量Theoretical: 68 kDa.
存储&运输
储存方式Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles.
运输方式Shipping with blue ice.

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