Anti-ACE2 Antibody (4J88)

Name: Anti-ACE2 Antibody (4J88)
Brand: TargetMol
SKU: TMAY-03714
Rating: 4.5 (1 reviews)

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货号 TMAY-03714

Anti-ACE2 Antibody (4J88) 是一种 Rabbit 抗体，靶向 ACE2。Anti-ACE2 Antibody (4J88) 可用于 ELISA。

Anti-ACE2 Antibody (4J88)

一键复制产品信息

还可以

货号 TMAY-03714

Anti-ACE2 Antibody (4J88) 是一种 Rabbit 抗体，靶向 ACE2。Anti-ACE2 Antibody (4J88) 可用于 ELISA。

规格	价格	库存	数量
20 μL	¥ 790	5日内发货
100 μL	¥ 2,284	5日内发货

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生物活性

产品描述	Anti-ACE2 Antibody (4J88) is a Rabbit antibody targeting ACE2. Anti-ACE2 Antibody (4J88) can be used in ELISA.
Ig Type	Rabbit IgG
克隆号	4J88
反应种属	Rat
特异性	Rat ACE2 Has cross-reactivity in ELISA with Human ACE2 Mouse ACE2 Rhesus ACE2
应用	ELISA
推荐剂量	ELISA: 1:5000-1:10000
抗体种类	Monoclonal
宿主来源	Rabbit
构建方式	This antibody was obtained from a rabbit immunized with purified, recombinant Rat ACE2 (rR ACE2; TMPY-02207; Q5EGZ1; Met 1-Thr 740).
纯化方式	Protein A
性状	Liquid
缓冲液	0.2 μm filtered solution in PBS
研究背景	Angiotensin-converting enzyme 2 (ACE2), a first homolog of ACE, regulates the renin angiotensin system (RAS) by counterbalancing ACE activity. Accumulating evidence in recent years has demonstrated a physiological and pathological role of ACE2 in the cardiovascular, renal and respiratory systems. ACE2 also has an important role in blood pressure control. This enzyme, an homolog of ACE, hydrolyzes angiotensin (Ang) I to produce Ang-(1-9), which is subsequently converted into Ang-(1-7) by a neutral endopeptidase and ACE. ACE2 releases Ang-(1-7) more efficiently than its catalysis of Ang-(1-9) by cleavage of Pro(7)-Phe(8) bound in Ang II. Thus, the major biologically active product of ACE2 is Ang-(1-7), which is considered to be a beneficial peptide of the RAS cascade in the cardiovascular system. A physiological role for ACE2 has been implicated in hypertension, cardiac function, heart function and diabetes, and as a receptor of the severe acute respiratory syndrome coronavirus. In the acute respiratory distress syndrome (ARDS), ACE, AngII, and AT1R promote the disease pathogenesis, whereas ACE2 and the AT2R protect from ARDS. Importantly, ACE2 has been identified as a key SARS-coronavirus receptor and plays a protective role in severe acute respiratory syndrome (SARS) pathogenesis. Furthermore, the recent explosion of research into the ACE2 homolog, collectrin, has revealed a new physiological function of ACE2 as an amino acid transporter, which explains the pathogenic role of gene mutations in Hartnup disorder. This review summarizes and discusses the recently unveiled roles for ACE2 in disease pathogenesis.

偶联与修饰

偶联	Unconjugated

抗原信息

免疫原	Recombinant Protein: Rat ACE2 protein (TMPY-02207)
抗原种属	Rat

储存&溶解度

储存方式	Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. Preservative-Free.
运输方式	Shipping with blue ice.