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Anti-GPR43 Polyclonal Antibody 2

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货号 TMAB-00796

别名 GPR 43, GPCR GPR43, GPCR 43, G protein coupled receptor 43, Free fatty acid receptor 2, free fatty acid activated receptor 2, FFAR2, FFA2R

Anti-GPR43 Polyclonal Antibody 2 是一种 Rabbit 抗体，靶向 GPR43。Anti-GPR43 Polyclonal Antibody 2 可用于 WB。

Anti-GPR43 Polyclonal Antibody 2

Anti-GPR43 Polyclonal Antibody 2

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货号 TMAB-00796 别名 GPR 43, GPCR GPR43, GPCR 43, G protein coupled receptor 43, Free fatty acid receptor 2, free fatty acid activated receptor 2, FFAR2, FFA2R

Anti-GPR43 Polyclonal Antibody 2 是一种 Rabbit 抗体，靶向 GPR43。Anti-GPR43 Polyclonal Antibody 2 可用于 WB。

规格价格库存数量
50 μL
¥ 1,175
5日内发货
100 μL
¥ 1,975
5日内发货
200 μL
¥ 2,790
5日内发货
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产品介绍

生物活性
产品描述
Anti-GPR43 Polyclonal Antibody 2 is a Rabbit antibody targeting GPR43. Anti-GPR43 Polyclonal Antibody 2 can be used in WB.
别名GPR 43, GPCR GPR43, GPCR 43, G protein coupled receptor 43, Free fatty acid receptor 2, free fatty acid activated receptor 2, FFAR2, FFA2R
Ig Type
IgG
反应种属
Mouse (predicted:Rat)
验证活性
Sample:
Lane 1: Mouse Lung tissue lysates
Lane 2: Mouse Stomach tissue lysates
Primary: Anti-GPR43 (TMAB-00796) at 1/1000 dilution
Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution
Predicted band size: 31 kDa
Observed band size: 52 kDa
verifiedActivity
应用WB
推荐剂量
WB: 1:500-2000
抗体种类
Polyclonal
宿主来源Rabbit
亚细胞定位Cell membrane.
组织特异性Expressed at relatively high levels in peripheral blood leukocytes and, to lesser, extent, in spleen.
构建方式Polyclonal Antibody
纯化方式Protein A purified
性状Liquid
缓冲液0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
浓度1 mg/mL
研究背景G protein-coupled receptors provide attractive targets for drug therapy due to the sheer size and diversity of ligands within this receptor family. G protein-coupled receptor (GPR) GPR41 and GPR43 are related members of a homologous family of orphan G protein-coupled receptors that are tandemly encoded at a single chromosomal locus in both humans and mice. GPR43 functions as a ligand for short chain fatty acids (SCFAs), notably acetate and propionate. Bacteria in the gut produce high concentrations of SCFAs, which are subsequently released in the bloodstream, where they exert cellular effects on blood leukocytes, including calcium release, ERK1/2 activation, and inhibition of cAMP accumulation. These effects indicate a role for GPR43 in the recruitment of leukocytes, particularly polymorphonuclear cells, to sites of bacterial infection.
抗原信息
免疫原
KLH conjugated synthetic peptide: mouse GPR43
抗原种属
Mouse
基因名称
FFAR2
蛋白名称
Free fatty acid receptor 2
研究领域
GPCR
功能
Receptor for short chain fatty acids through a G(i)-protein-mediated inhibition of adenylyl cyclase and elevation of intracellular calcium. The rank order of potency for agonists of this receptor is acetate= propionate = butyrate > pentanoate = formate.
化学信息
分子量Theoretical: 31 kDa.
储存&溶解度
储存方式Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles.
运输方式Shipping with blue ice.
存储store at low temperature | store at -20°C

计算器

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