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CD28 Protein, Human/Cynomolgus, Recombinant (His)

CD28 Protein, Human/Cynomolgus, Recombinant (His)

产品编号 TMPJ-00103
别名: CD28 antigen, CD28 molecule, T-cell-specific surface glycoprotein CD28, CD28, Tp44

CD28 Protein, Human/Cynomolgus, Recombinant (His) is expressed in HEK293 mammalian cells with N-6xHis tag. The predicted molecular weight is 30-40 KDa and the accession number is P10747.

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CD28 Protein, Human/Cynomolgus, Recombinant (His)
规格 价格/CNY 货期 数量
10 μg ¥ 550 现货
50 μg ¥ 1,670 5日内发货
500 μg ¥ 13,000 5日内发货
1 mg ¥ 19,500 5日内发货
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产品目录号及名称: CD28 Protein, Human/Cynomolgus, Recombinant (His) (TMPJ-00103)
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生物活性
技术参数
产品性质
生物活性 1. Loaded Anti-Human CD28 mAb-Fc on Protein A Biosensor, can bind Human/Cynomolgus CD28-His with an affinity constant of 0.77 nM as determined in BLI assay. (Regularly tested) 2. Immobilized Human/Cynomolgus CD28-His at 2μg/ml (100 μl/well) can bind Anti-CD28 mAb The ED50 of Anti-CD28 mAb is 15.3 ng/ml. (Regularly tested)

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产品描述 CD28 Protein, Human/Cynomolgus, Recombinant (His) is expressed in HEK293 mammalian cells with N-6xHis tag. The predicted molecular weight is 30-40 KDa and the accession number is P10747.
种属 Human,Cynomolgus
表达系统 HEK293 Cells
标签 N-6xHis
蛋白编号 P10747
别名 CD28 antigen, CD28 molecule, T-cell-specific surface glycoprotein CD28, CD28, Tp44
氨基酸序列 Asn19-Pro152
蛋白构建 Asn19-Pro152
蛋白纯度 Greater than 95% as determined by reducing SDS-PAGE. (QC verified)

TargetMol

分子量 30-40 KDa (reducing condition)
内毒素 < 0.1 ng/µg (1 EU/µg) as determined by LAL test.
缓冲液 Lyophilized from a solution filtered through a 0.22 μm filter, containing 20 mM Tris-HCl, 150 mM NaCl, pH 8.0.
复溶方法 Reconstitute the lyophilized protein in distilled water. The product concentration should not be less than 100 μg/ml. Before opening, centrifuge the tube to collect powder at the bottom. After adding the reconstitution buffer, avoid vortexing or pipetting for mixing.
存储

Lyophilized powders can be stably stored for over 12 months, while liquid products can be stored for 6-12 months at -80°C. For reconstituted protein solutions, the solution can be stored at -20°C to -80°C for at least 3 months. Please avoid multiple freeze-thaw cycles and store products in aliquots.

运输方式

In general, Lyophilized powders are shipping with blue ice. Solutions are shipping with dry ice.

研究背景 T-cell-specific surface glycoprotein CD28(CD28) is a single-pass typeI membrane protein which contains one Ig-likeV-type (immunoglobulin-like) domain. It belongs to the immunoglobulin(Ig) superfamily. CD28 is one of the molecules expressed on T cells that provide co-stimulatory signals, which are required for T cell activation.CD28 co-stimulation is necessary for CD4 positive T-cell proliferation and survival, interleukin-2 production, and T-helper type-2 development. Human post-thymic regulatory T cells require CD28 co-stimulation to expand and maintain potent suppressive function in vivo. Apoptosis plays a key role in the age-related decline of CD28 expression and in immunosenescence. CD28 is the receptor for CD80 (B7.1) and CD86 (B7.2). When activated by Toll-like receptor ligands, the CD80 expression is upregulated in antigen presenting cells (APCs). The CD86 expression on antigen presenting cells is constitutive. CD28 is the only B7 receptor constitutively expressed on naive T cells.

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Keywords

CD28 Protein, Human/Cynomolgus, Recombinant (His) CD 28 CD28 antigen CD-28 CD28 molecule T-cell-specific surface glycoprotein CD28 CD28 Tp44 recombinant recombinant-proteins proteins protein

 

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