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Anti-CDX1 Antibody (5H993) 是一种 Rabbit 抗体,靶向 CDX1。Anti-CDX1 Antibody (5H993) 可用于 WB,ICC。
Anti-CDX1 Antibody (5H993) 是一种 Rabbit 抗体,靶向 CDX1。Anti-CDX1 Antibody (5H993) 可用于 WB,ICC。
规格 | 价格 | 库存 | 数量 |
---|---|---|---|
50 μL | ¥ 1,490 | 5日内发货 | |
100 μL | ¥ 2,485 | 5日内发货 |
产品描述 | Anti-CDX1 Antibody (5H993) is a Rabbit antibody targeting CDX1. Anti-CDX1 Antibody (5H993) can be used in WB,ICC. |
别名 | Homeobox protein CDX-1, CDX 1, Caudal-type homeobox protein 1 |
Ig Type | IgG |
交叉反应 | Human |
验证活性 | 1. Western blot analysis of Cdx1 on human small intestine tissue (1) and CRC cell (2) lysate using anti-Cdx1 antibody at 1/1,000 dilution. 2. ICC staining Cdx1 in HOVO cells (green). The nuclear counter stain is DAPI (blue). Cells were fixed in paraformaldehyde, permeabilised with 0.25% Triton X100/PBS. |
应用 | |
推荐剂量 | WB: 1:500-2000; ICC: 1:50-200 |
抗体种类 | Monoclonal |
宿主来源 | Rabbit |
构建方式 | Recombinant Antibody |
纯化方式 | ProA affinity purified |
性状 | Liquid |
缓冲液 | 1*TBS (pH7.4), 1%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide. |
研究背景 | The members of the murine Cdx family (Cdx1, Cdx2, and Cdx4) are members of the caudal-type homeobox family of genes, which are homologues of the Drosophila 'caudal' gene required for anterior-posterior regional identity. The intestine-specific transcription factors Cdx1 and Cdx2 are candidate genes for directing intestinal development, differentiation, proliferation and maintenance of the intestinal phenotype. The relative expression of Cdx1 to Cdx2 protein may be important in the anterior to posterior patterning of the intestinal epithelium and in defining patterns of proliferation and differentiation along the crypt-villus axis. Expression of the Cdx1 homeobox gene in epithelial intestinal cells promotes cellular growth and differentiation. Cdx1 positively regulates its own expression. Cdx1 and Cdx2 are expressed in the small intestine and colon of fetus and adult. A decrease in human Cdx1 and/or Cdx2 expression is associated with colorectal tumorigenesis. Both Cdx1 and Cdx2 genes must be expressed to reduce tumorigenic potential, to increase sensitivity to apoptosis and to reduce cell migration, suggesting that the two genes control the normal phenotype by independent pathways. The human Cdx1 gene maps to chromosome 5q31-q33 and encodes a 265-amino acid protein. |
偶联 | Unconjugated |
免疫原 | Recombinant Protein: full lenth sequence of human Cdx1 |
抗原种属 | human |
Uniprot ID |
分子量 | Theoretical: 28 kDa. |
储存方式 | Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. |
运输方式 | Shipping with blue ice. |
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