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顶部生物活性储存和溶解信息计算器

Anti-Phospho-RELB (Ser536) Polyclonal Antibody

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Anti-Phospho-RELB (Ser536) Polyclonal Antibody
产品编号 TMAC-02814
别名 RELB (p-Ser536), RELB (p-S536), p-RELB (Ser536), p-RELB (S536)

Anti-Phospho-RELB (Ser536) Polyclonal Antibody 是一种 Rabbit 抗体，靶向 Phospho-RELB (Ser536)。Anti-Phospho-RELB (Ser536) Polyclonal Antibody 可用于 WB,IHC,IF。

Anti-Phospho-RELB (Ser536) Polyclonal Antibody

Anti-Phospho-RELB (Ser536) Polyclonal Antibody

Rating icon 还可以
Anti-Phospho-RELB (Ser536) Polyclonal Antibody
产品编号 TMAC-02814 别名 RELB (p-Ser536), RELB (p-S536), p-RELB (Ser536), p-RELB (S536)

Anti-Phospho-RELB (Ser536) Polyclonal Antibody 是一种 Rabbit 抗体，靶向 Phospho-RELB (Ser536)。Anti-Phospho-RELB (Ser536) Polyclonal Antibody 可用于 WB,IHC,IF。

规格价格库存数量
50 μL
¥ 1,485
5日内发货
100 μL
¥ 2,235
5日内发货
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产品介绍

生物活性
产品描述
Anti-Phospho-RELB (Ser536) Polyclonal Antibody is a Rabbit antibody targeting Phospho-RELB (Ser536). Anti-Phospho-RELB (Ser536) Polyclonal Antibody can be used in WB,IHC,IF.
别名RELB (p-Ser536), RELB (p-S536), p-RELB (Ser536), p-RELB (S536)
Ig Type
IgG
交叉反应
Human,Mouse,Rat
验证活性
1. Western blot analysis of extracts from HepG2 and HL60 cells untreated or treated with TNF using NFkB-p65 (Phospho-Ser536) Antibody TMAC-02814.
2. Immunohistochemical analysis of paraffin-embedded human breast carcinoma tissue using NFκB-p65 (Phospho-Ser536) Antibody TMAC-02814 (left) or the same antibody preincubated with blocking peptide (right).
3. Immunofluorescence staining of methanol-fixed Hela cells using NFkB-p65 (Phospho-Ser536) Antibody TMAC-02814.
4. Immunohistochemical analysis of paraffin-embedded human breast carcinoma tissue using NFκB-p65 (Phospho-Ser536) Antibody TMAC-02814.
5. Immunohistochemical analysis of paraffin-embedded human Lung carcinoma tissue using NFκB-p65 (Phospho-Ser536) Antibody TMAC-02814.
6. Immunofluorescence staining of methanol-fixed MEF cells using NFκB-p65 (Phospho-Ser536) Antibody TMAC-02814.
应用
WB
IHC
IF
抗体种类
Polyclonal
宿主来源Rabbit
构建方式Polyclonal Antibody
纯化方式Antibodies were produced by immunizing rabbits with synthetic phosphopeptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific phosphopeptide. Non-phospho specific antibodies were removed by chromatogramphy using non-phosphopeptide.
性状Liquid
缓冲液Supplied at 1.0mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
研究背景NF-kappa-B is a pleiotropic transcription factor which is present in almost all cell types and is involved in many biological processed such as inflammation, immunity, differentiation, cell growth, tumorigenesis and apoptosis. NF-kappa-B is a homo- or heterodimeric complex formed by the Rel-like domain-containing proteins RELA/p65, RELB, NFKB1/p105, NFKB1/p50, REL and NFKB2/p52 and the heterodimeric p65-p50 complex appears to be most abundant one. The dimers bind at kappa-B sites in the DNA of their target genes and the individual dimers have distinct preferences for different kappa-B sites that they can bind with distinguishable affinity and specificity. Different dimer combinations act as transcriptional activators or repressors, respectively. NF-kappa-B is controlled by various mechanisms of post-translational modification and subcellular compartmentalization as well as by interactions with other cofactors or corepressors. NF-kappa-B complexes are held in the cytoplasm in an inactive state complexed with members of the NF-kappa-B inhibitor (I-kappa-B) family. In a conventional activation pathway, I-kappa-B is phosphorylated by I-kappa-B kinases (IKKs) in response to different activators, subsequently degraded thus liberating the active NF-kappa-B complex which translocates to the nucleus. NF-kappa-B heterodimeric p65-p50 and p65-c-Rel complexes are transcriptional activators. The NF-kappa-B p65-p65 complex appears to be involved in invasin-mediated activation of IL-8 expression. The inhibitory effect of I-kappa-B upon NF-kappa-B the cytoplasm is exerted primarily through the interaction with p65. p65 shows a weak DNA-binding site which could contribute directly to DNA binding in the NF-kappa-B complex.
偶联与修饰
偶联
Unconjugated
其他可选修饰符
Phospho
抗原信息
免疫原
Peptide sequence around phosphorylation site of serine 536 (F-S-S(p)-I-A) derived from Human NFkB-p65
抗原种属
human
Uniprot ID
Q04206
存储&运输
储存方式Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles.
运输方式Shipping with blue ice.

计算器

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关键词

RELB (pSer536)RELB (pS536)RELB (phospho-Ser536)RELB (phospho-S536)pRELB (Ser536)pRELB (S536)

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