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PRKAR1A Protein, Human, Recombinant (His)

产品编号 TMPY-03656

别名: PRKAR1, CAR, CNC1, PPNAD1, CNC, protein kinase, cAMP-dependent, regulatory, type I, alpha, TSE1, ACRDYS1, protein kinase, cAMP-dependent, regulatory, type I, α, ADOHR, PKR1

PRKAR1A Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 36.2 kDa and the accession number is P10644.

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PRKAR1A Protein, Human, Recombinant (His)

规格	价格/CNY		货期	数量
100 μg	￥ 4,460		5日内发货

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参考文献

生物活性	Testing in progress
产品描述	PRKAR1A Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 36.2 kDa and the accession number is P10644.

种属	Human
表达系统	HEK293 Cells
标签	C-His
蛋白编号	P10644
别名	PRKAR1, CAR, CNC1, PPNAD1, CNC, protein kinase, cAMP-dependent, regulatory, type I, alpha, TSE1, ACRDYS1, protein kinase, cAMP-dependent, regulatory, type I, α, ADOHR, PKR1
蛋白构建	The Human PRKAR1A (P10644) (Met1-Val381) was expressed with a polyhistidine tag at the C-terminus.
蛋白纯度	> 85 % as determined by SDS-PAGE
分子量	36.2 kDa (predicted)

内毒素	< 1.0 EU/μg of the protein as determined by the LAL method.
缓冲液	Lyophilized from a solution filtered through a 0.22 μm filter, containing 20 mM Tris, 500 mM Nacl, 10% glycerol, pH 7.4. Typically, a mixture containing 5% to 8% trehalose, mannitol, and 0.01% Tween 80 is incorporated as a protective agent before lyophilization.
复溶方法	A Certificate of Analysis (CoA) containing reconstitution instructions is included with the products. Please refer to the CoA for detailed information.
存储	It is recommended to store recombinant proteins at -20°C to -80°C for future use. Lyophilized powders can be stably stored for over 12 months, while liquid products can be stored for 6-12 months at-80℃. For reconstituted protein solutions, the solution can be stored at -20°c to -80'c for at least 3 months. Please avoid multiple freeze-thaw cycles and store products in aliquots.
运输方式	In general, Lyophilized powders are shipping with blue ice.
研究背景	PRKAR1A, also known as PRKAR1 and PKR1, is one of the regulatory subunits of cAMP-dependent protein kinase A (PKA). PKA can be activated by cAMP. cAMP is a signaling molecule important for a variety of cellular functions. cAMP exerts its effects by activating PKA, which transduces the signal throughphosphorylation of different target proteins. The inactive holoenzyme of PKA is a tetramer composed of two regulatory and two catalytic subunits. cAMP causes the dissociation of the inactive holoenzyme into a dimer of regulatory subunits bound to four cAMP and two free monomeric catalytic subunits. Four different regulatory subunits and three catalytic subunits of PKA have been identified in humans. PRKAR1A was found to be a tissue-specific extinguisher that down-regulates the expression of seven liver genes in hepatoma x fibroblast hybrids Three alternatively spliced transcript variants encoding the same protein have been observed.

参考文献

1. Huang L J. et al., 1997, Proc Natl Acad Sci. 94 (21): 11184-9. 2. Herberg F W. et al., 2000, J Mol Biol. 298 (2): 329-39. 3. Scambler P. et al., 1987, Am J Hum Genet. 41 (5): 925-32.

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Keywords

PRKAR1A Protein, Human, Recombinant (His) PKR-1 ACRDYS-1 TSE 1 CNC-1 PRKAR1 CAR ACRDYS 1 TSE-1 CNC1 PKR 1 PPNAD1 PPNAD 1 CNC 1 CNC protein kinase, cAMP-dependent, regulatory, type I, alpha TSE1 ACRDYS1 PRKAR-1 protein kinase, cAMP-dependent, regulatory, type I, α ADOHR PKR1 PRKAR 1 PPNAD-1 recombinant recombinant-proteins proteins protein

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