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Anti-CD3 epsilon/CD3e Antibody (6O384)

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产品编号 TMAY-01395

别名 CD3e molecule, ε (CD3-TCR complex), CD3e molecule, epsilon (CD3-TCR complex), CD3 ε/CD3e

Anti-CD3 epsilon/CD3e Antibody (6O384) 是一种 Mouse 抗体，靶向 CD3 epsilon/CD3e。Anti-CD3 epsilon/CD3e Antibody (6O384) 可用于 FCM。

Anti-CD3 epsilon/CD3e Antibody (6O384)

Anti-CD3 epsilon/CD3e Antibody (6O384)

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Rating icon 还可以
产品编号 TMAY-01395 别名 CD3e molecule, ε (CD3-TCR complex), CD3e molecule, epsilon (CD3-TCR complex), CD3 ε/CD3e

Anti-CD3 epsilon/CD3e Antibody (6O384) 是一种 Mouse 抗体，靶向 CD3 epsilon/CD3e。Anti-CD3 epsilon/CD3e Antibody (6O384) 可用于 FCM。

规格价格库存数量
20 μL
¥ 780
5日内发货
100 μL
¥ 2,294
5日内发货
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产品介绍

生物活性
产品描述
Anti-CD3 epsilon/CD3e Antibody (6O384) is a Mouse antibody targeting CD3 epsilon/CD3e. Anti-CD3 epsilon/CD3e Antibody (6O384) can be used in FCM.
别名CD3e molecule, ε (CD3-TCR complex), CD3e molecule, epsilon (CD3-TCR complex), CD3 ε/CD3e
Ig Type
Mouse IgG2a
克隆号
6O384
交叉反应
Human
特异性
Human CD3 epsilon/CD3e
验证活性
Flow cytometric analysis of Human CD3 expression on human peripheral blood lymphocytes. Cells were stained with purified Mouse anti-Human CD3, then a PE-conjugated second step antibody. The histogram were derived from events with the forward and side light-scatter characteristics of viable lymphocytes.
应用FCM
推荐剂量
FCM: 1:25-1:100
抗体种类
Monoclonal
宿主来源Mouse
构建方式This product is a recombinant monoclonal antibody expressed from HEK293 cells.
纯化方式Protein A
性状Liquid
缓冲液0.2 μm filtered solution in PBS
研究背景T-cell surface glycoprotein CD3 epsilon chain, also known as CD3E, is a single-pass type I membrane protein. CD3E contains 1 Ig-like (immunoglobulin-like) domain and 1 ITAM domain. CD3E, together with CD3-gamma, CD3-delta and CD3-zeta, and the T-cell receptor alpha/beta and gamma/delta heterodimers, forms the T cell receptor-CD3 complex. The CD3 epsilon subunit of the T cell receptor (TCR) complex contains two defined signaling domains, a proline-rich sequence and an immune tyrosine activation motifs (ITAMs), and this complex undergoes a conformational change upon ligand binding that is thought to be important for the activation of T cells. In the CD3 epsilon mutant mice, all stages of T cell development and activation that are TCR-dependent were impaired, but not eliminated, including activation of mature naïve T cells with the MHCII presented superantigen, staphylococcal enterotoxin B, or with a strong TCR cross-linking antibody specific for either TCR-Cbeta or CD3 epsilon. T cell receptor-CD3 complex plays an important role in coupling antigen recognition to several intracellular signal-transduction pathways. This complex is critical for T-cell development and function, and represents one of the most complex transmembrane receptors. CD3E plays an essential role in T-cell development, and defects in CD3E gene cause severe immunodeficiency. Homozygous mutations in CD3D and CD3E genes lead to a complete block in T-cell development and thus to an early-onset severe combined immunodeficiency phenotype.Cancer ImmunotherapyImmune CheckpointImmunotherapyTargeted Therapy
偶联与修饰
偶联
Unconjugated
其他可选修饰符
APC/PerCP/FITC/PE
可提供抗体种类
5
抗原信息
免疫原
Recombinant Protein: Human CD3e / CD3 epsilon protein (TMPY-01191)
抗原种属
Human
研究领域
ITIM/ITAM Immunoreceptors and Related Molecules
存储&运输
储存方式Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. Preservative-Free.
运输方式Shipping with blue ice.

计算器

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关键词

CD3-TCR complexCD3e molecule, epsilon

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