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CCL16 Protein, Human, Recombinant

CCL16 Protein, Human, Recombinant

产品编号 TMPJ-00018
别名: NCC-4, Lymphocyte and Monocyte Chemoattractant, LMC, NCC4, HCC-4, ILINCK, Chemokine CC-4, LCC-1, CCL16, Monotactin-1, MTN-1, IL-10-Inducible Chemokine, C-C Motif Chemokine 16, Chemokine LEC, Small-Inducible Cytokine A16, SCYA16, Liver-Expressed Chemokine

CCL16 is a member of CC chemokine family. CCL16 cDNA encodes a 120 amino acid peptide along with a 23 amino acids signal peptide that is cleaved to generate 97 amino acid protein. CCL16 is distantly related to other CC chemokines, showing less than 30% sequence identity. CCL16 elicits its effects on cells by interacting with cell surface chemokine receptors such as CCR1, CCR2, CCR5 and CCR8. Recombinant CCL16 has been shown to chemoattract human monocytes and THP1 cells but not resting lymphocytes nor neutrophils. CCL16 has potent myelosuppressive activity, suppresses proliferation of myeloid progenitor cells. CCL16ninduces a calcium flux in THP1 cells that can be desensitized by prior exposure to RANTES, suggesting that CCL16 and RANTES share the same receptor in THP1 cells.

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CCL16 Protein, Human, Recombinant
规格 价格/CNY 货期 数量
10 μg ¥ 910 5日内发货
50 μg ¥ 2,760 5日内发货
500 μg ¥ 12,100 5日内发货
1 mg ¥ 17,400 5日内发货
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产品目录号及名称: CCL16 Protein, Human, Recombinant (TMPJ-00018)
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技术参数
产品性质
产品描述 CCL16 is a member of CC chemokine family. CCL16 cDNA encodes a 120 amino acid peptide along with a 23 amino acids signal peptide that is cleaved to generate 97 amino acid protein. CCL16 is distantly related to other CC chemokines, showing less than 30% sequence identity. CCL16 elicits its effects on cells by interacting with cell surface chemokine receptors such as CCR1, CCR2, CCR5 and CCR8. Recombinant CCL16 has been shown to chemoattract human monocytes and THP1 cells but not resting lymphocytes nor neutrophils. CCL16 has potent myelosuppressive activity, suppresses proliferation of myeloid progenitor cells. CCL16ninduces a calcium flux in THP1 cells that can be desensitized by prior exposure to RANTES, suggesting that CCL16 and RANTES share the same receptor in THP1 cells.
种属 Human
表达系统 E. coli
标签 Tag Free
蛋白编号 O15467
别名 NCC-4, Lymphocyte and Monocyte Chemoattractant, LMC, NCC4, HCC-4, ILINCK, Chemokine CC-4, LCC-1, CCL16, Monotactin-1, MTN-1, IL-10-Inducible Chemokine, C-C Motif Chemokine 16, Chemokine LEC, Small-Inducible Cytokine A16, SCYA16, Liver-Expressed Chemokine
氨基酸序列 Gln24-Gln120
蛋白构建 Gln24-Gln120
分子量 14 KDa (reducing condition)
内毒素 < 0.1 ng/µg (1 EU/µg) as determined by LAL test.
缓冲液 Lyophilized from a solution filtered through a 0.22 μm filter, containing 20 mM PB, 150 mM NaCl, pH 7.4.
复溶方法 Reconstitute the lyophilized protein in distilled water. The product concentration should not be less than 100 μg/ml. Before opening, centrifuge the tube to collect powder at the bottom. After adding the reconstitution buffer, avoid vortexing or pipetting for mixing.
存储

Lyophilized powders can be stably stored for over 12 months, while liquid products can be stored for 6-12 months at -80°C. For reconstituted protein solutions, the solution can be stored at -20°C to -80°C for at least 3 months. Please avoid multiple freeze-thaw cycles and store products in aliquots.

运输方式

In general, Lyophilized powders are shipping with blue ice. Solutions are shipping with dry ice.

研究背景 CCL16 is a member of CC chemokine family. CCL16 cDNA encodes a 120 amino acid peptide along with a 23 amino acids signal peptide that is cleaved to generate 97 amino acid protein. CCL16 is distantly related to other CC chemokines, showing less than 30% sequence identity. CCL16 elicits its effects on cells by interacting with cell surface chemokine receptors such as CCR1, CCR2, CCR5 and CCR8. Recombinant CCL16 has been shown to chemoattract human monocytes and THP1 cells but not resting lymphocytes nor neutrophils. CCL16 has potent myelosuppressive activity, suppresses proliferation of myeloid progenitor cells. CCL16ninduces a calcium flux in THP1 cells that can be desensitized by prior exposure to RANTES, suggesting that CCL16 and RANTES share the same receptor in THP1 cells.

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Keywords

CCL16 Protein, Human, Recombinant NCC-4 Lymphocyte and Monocyte Chemoattractant LMC HCC4 NCC4 MTN1 HCC-4 LCC 1 ILINCK Chemokine CC-4 LCC-1 MTN 1 CCL16 SCYA-16 SCYA 16 Monotactin-1 MTN-1 IL-10-Inducible Chemokine CCL 16 NCC 4 C-C Motif Chemokine 16 Chemokine LEC CCL-16 HCC 4 Small-Inducible Cytokine A16 SCYA16 Liver-Expressed Chemokine LCC1 recombinant recombinant-proteins proteins protein

 

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