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Anti-EGR2 Antibody (7J609)
还可以产品编号 TMAH-00381
别名 Zinc finger protein Krox-20, KROX20, EGR-2, EGR2, Early growth response protein 2, E3 SUMO-protein transferase ERG2, E3 SUMO-protein ligase EGR2, AT591
Anti-EGR2 Antibody (7J609) 是一种抗体，靶向 EGR2。Anti-EGR2 Antibody (7J609) 可用于 ELISA, WB, FC。
Anti-EGR2 Antibody (7J609)
Anti-EGR2 Antibody (7J609)
还可以产品编号 TMAH-00381 别名 Zinc finger protein Krox-20, KROX20, EGR-2, EGR2, Early growth response protein 2, E3 SUMO-protein transferase ERG2, E3 SUMO-protein ligase EGR2, AT591
Anti-EGR2 Antibody (7J609) 是一种抗体，靶向 EGR2。Anti-EGR2 Antibody (7J609) 可用于 ELISA, WB, FC。
| 规格 | 价格 | 库存 | 数量 |
|---|---|---|---|
| 50 μL | ¥ 1,315 | 5日内发货 | |
| 100 μL | ¥ 2,180 | 5日内发货 |
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产品介绍
生物活性
偶联与修饰
抗原信息
| 产品描述 | Anti-EGR2 Antibody (7J609) is an antibody targeting EGR2. Anti-EGR2 Antibody (7J609) can be used in ELISA, WB, FC. |
| 别名 | Zinc finger protein Krox-20, KROX20, EGR-2, EGR2, Early growth response protein 2, E3 SUMO-protein transferase ERG2, E3 SUMO-protein ligase EGR2, AT591 |
| Ig Type | Rabbit IgG |
| 克隆号 | 7J609 |
| 交叉反应 | Human, Mouse |
| 验证活性 | 1. Western Blot -Positive WB detected in: SY5Y whole cell lysate,U251 whole cell lysate,MCF7 whole cell lysate,K562 whole cell lysate,Mouse Brain tissue lysate,Mouse Brain tissue lysate -All lanes: EGR2 antibody at 1:1000 -Secondary: Goat polyclonal to rabbit IgG at 1/50000 dilution -Predicted band size: 50 kDa -Observed band size: 50 kDa 2. Overlay Peak curve showing SH-SY5Y cells stained with TMAH-00381 (red line) at 1:50. The cells were fixed in 4% formaldehyde and permeated by 0.2% TritonX-100. Then 10% normal goat serum to block non-specific protein-protein interactions followed by the antibody (1µg/1*10^6 cells) for 45min at 4°C. The secondary antibody used was FITC-conjugated Goat Anti-rabbit IgG(H+L) at 1:200 dilution for 35min at 4°C.Control antibody (green line) was rabbit IgG (1µg/1*10^6 cells) used under the same conditions. Acquisition of >10,000 events was performed. |
| 应用 | ELISA, WB, FC |
| 推荐剂量 | WB:1:500-1:2000; FC:1:50-1:200. |
| 抗体种类 | Monoclonal |
| 亚细胞定位 | Nucleus. |
| 构建方式 | Recombinant Antibody |
| 纯化方式 | Affinity-chromatography |
| 性状 | Liquid |
| 缓冲液 | Phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
| 研究背景 | Sequence-specific DNA-binding transcription factor. Plays a role in hindbrain segmentation by regulating the expression of a subset of homeobox containing genes and in Schwann cell myelination by regulating the expression of genes involved in the formation and maintenance of myelin. Binds to two EGR2-consensus sites EGR2A (5'-CTGTAGGAG-3') and EGR2B (5'-ATGTAGGTG-3') in the HOXB3 enhancer and promotes HOXB3 transcriptional activation. Binds to specific DNA sites located in the promoter region of HOXA4, HOXB2 and ERBB2. Regulates hindbrain segmentation by controlling the expression of Hox genes, such as HOXA4, HOXB3 and HOXB2, and thereby specifying odd and even rhombomeres. Promotes the expression of HOXB3 in the rhombomere r5 in the hindbrain. Regulates myelination in the peripheral nervous system after birth, possibly by regulating the expression of myelin proteins, such as MPZ, and by promoting the differentiation of Schwann cells. Involved in the development of the jaw openener musculature, probably by playing a role in its innervation through trigeminal motor neurons. May play a role in adipogenesis, possibly by regulating the expression of CEBPB. E3 SUMO-protein ligase helping SUMO1 conjugation to its coregulators NAB1 and NAB2, whose sumoylation down-regulates EGR2 transcriptional activity. |
| 偶联 | Unconjugated |
| 免疫原 | A synthetic peptide: Human EGR2 |
| 抗原种属 | Human |
| 基因ID | 1959 |
| Uniprot ID | |
| 研究领域 | Epigenetics and Nuclear Signaling, Neuroscience |
存储&运输
| 储存方式 | Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. |
| 运输方式 | Shipping with blue ice. |
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比如您的给药剂量是 10 mg/kg ，每只动物体重 20 g ，给药体积 100 μL ， 
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