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顶部生物活性储存和溶解信息计算器

Anti-Phospho-PTEN (Ser370) Polyclonal Antibody

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Anti-Phospho-PTEN (Ser370) Polyclonal Antibody
产品编号 TMAC-03461
别名 TEP1, PTEN1, PTEN (p-Ser370), PTEN (p-S370), p-PTEN (Ser370), p-PTEN (S370), Phospho-PTEN (S370), Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN, Phosphatase and tensin like protein, Phosphatase and tensin homolog, Mutated in multiple advanced cancers 1, MMAC1 phosphatase and tensin homolog deleted on chromosome 10, MMAC1, MHAM, MGC11227, GLM2, DEC, BZS, 10q23del

Anti-Phospho-PTEN (Ser370) Polyclonal Antibody 是一种 Rabbit 抗体，靶向 Phospho-PTEN (Ser370)。Anti-Phospho-PTEN (Ser370) Polyclonal Antibody 可用于 WB,IHC,IF。

Anti-Phospho-PTEN (Ser370) Polyclonal Antibody

Anti-Phospho-PTEN (Ser370) Polyclonal Antibody

Rating icon 还可以
Anti-Phospho-PTEN (Ser370) Polyclonal Antibody
产品编号 TMAC-03461 别名 TEP1, PTEN1, PTEN (p-Ser370), PTEN (p-S370), p-PTEN (Ser370), p-PTEN (S370), Phospho-PTEN (S370), Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN, Phosphatase and tensin like protein, Phosphatase and tensin homolog, Mutated in multiple advanced cancers 1, MMAC1 phosphatase and tensin homolog deleted on chromosome 10, MMAC1, MHAM, MGC11227, GLM2, DEC, BZS, 10q23del

Anti-Phospho-PTEN (Ser370) Polyclonal Antibody 是一种 Rabbit 抗体，靶向 Phospho-PTEN (Ser370)。Anti-Phospho-PTEN (Ser370) Polyclonal Antibody 可用于 WB,IHC,IF。

规格价格库存数量
50 μL
¥ 1,485
5日内发货
100 μL
¥ 2,230
5日内发货
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产品介绍

生物活性
产品描述
Anti-Phospho-PTEN (Ser370) Polyclonal Antibody is a Rabbit antibody targeting Phospho-PTEN (Ser370). Anti-Phospho-PTEN (Ser370) Polyclonal Antibody can be used in WB,IHC,IF.
别名TEP1, PTEN1, PTEN (p-Ser370), PTEN (p-S370), p-PTEN (Ser370), p-PTEN (S370), Phospho-PTEN (S370), Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN, Phosphatase and tensin like protein, Phosphatase and tensin homolog, Mutated in multiple advanced cancers 1, MMAC1 phosphatase and tensin homolog deleted on chromosome 10, MMAC1, MHAM, MGC11227, GLM2, DEC, BZS, 10q23del
Ig Type
IgG
交叉反应
Human,Mouse,Rat
验证活性
1. Western blot analysis of extracts from HeLa cells using PTEN (phospho-Ser370) antibody (TMAC-03461).
2. Immunohistochemical analysis of paraffin- embedded human breast carcinoma tissue using PTEN (phospho-Ser370) antibody (TMAC-03461).
3. Immunofluorescence staining of methanol-fixed MCF7 cells using PTEN (phospho-Ser370) antibody (TMAC-03461, Red).
应用
WB
IHC
IF
抗体种类
Polyclonal
宿主来源Rabbit
构建方式Polyclonal Antibody
纯化方式Antibodies were produced by immunizing rabbits with synthetic phosphopeptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific phosphopeptide. Non-phospho specific antibodies were removed by chromatogramphy using non-phosphopeptide.
性状Liquid
缓冲液Supplied at 1.0mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
研究背景Tumor suppressor. Acts as a dual-specificity protein phosphatase, dephosphorylating tyrosine-, serine- and threonine-phosphorylated proteins. Also acts as a lipid phosphatase, removing the phosphate in the D3 position of the inositol ring from phosphatidylinositol 3,4,5-trisphosphate, phosphatidylinositol 3,4-diphosphate, phosphatidylinositol 3-phosphate and inositol 1,3,4,5-tetrakisphosphate with order of substrate preference in vitro PtdIns(3,4,5)P3 > PtdIns(3,4)P2 > PtdIns3P > Ins(1,3,4,5)P4. The lipid phosphatase activity is critical for its tumor suppressor function. Antagonizes the PI3K-AKT/PKB signaling pathway by dephosphorylating phosphoinositides and thereby modulating cell cycle progression and cell survival. The unphosphorylated form cooperates with AIP1 to suppress AKT1 activation. Dephosphorylates tyrosine-phosphorylated focal adhesion kinase and inhibits cell migration and integrin-mediated cell spreading and focal adhesion formation. Plays a role as a key modulator of the AKT-mTOR signaling pathway controlling the tempo of the process of newborn neurons integration during adult neurogenesis, including correct neuron positioning, dendritic development and synapse formation. May be a negative regulator of insulin signaling and glucose metabolism in adipose tissue. The nuclear monoubiquitinated form possesses greater apoptotic potential, whereas the cytoplasmic nonubiquitinated form induces less tumor suppressive ability.
偶联与修饰
偶联
Unconjugated
其他可选修饰符
Phospho
抗原信息
免疫原
Peptide sequence around phosphorylation site of serine 370(D-V-S(p)-D-N) derived from Human PTEN
抗原种属
human
Uniprot ID
P60484
存储&运输
储存方式Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles.
运输方式Shipping with blue ice.

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关键词

PTEN (pSer370)PTEN (pS370)PTEN (phospho-Ser370)PTEN (phospho-S370)pPTEN (Ser370)pPTEN (S370)

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