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ITPase Protein, Human, Recombinant (His)

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货号 TMPJ-01308

别名 Putative Oncog, Nucleoside-Triphosphate Pyrophosphatase, Nucleoside-Triphosphate Diphosphatase, NTPase, Non-Standard Purine NTP Pyrophosphatase, Non-Canonical Purine NTP Pyrophosphatase, ITPase, Inosine Triphosphate Pyrophosphatase, Inosine Triphosphatase

Inosine Triphosphate Pyrophosphatase (ITPase) is a cytoplasmic enzyme that belongs to the HAM1 NTPase family. ITPase hydrolyzes the non-canonical purine nucleotides inosine triphosphate (ITP) and deoxyinosine triphosphate (dITP) to the monophosphate nucleotide (IMP) and diphosphate. The ITPase enzyme acts as a homodimer and does not distinguish between the deoxy- and ribose forms. ITPase probably excludes non-canonical purines from RNA and DNA precursor pools, thus preventing their incorporation into RNA and DNA and avoiding chromosomal lesions. Defects in ITPase is thought to be inherited and is characterized by an over-accumulation of ITP in erythocytes, leukocytes and fibroblasts.

ITPase Protein, Human, Recombinant (His)
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ITPase Protein, Human, Recombinant (His)

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货号 TMPJ-01308 别名 Putative Oncog, Nucleoside-Triphosphate Pyrophosphatase, Nucleoside-Triphosphate Diphosphatase, NTPase, Non-Standard Purine NTP Pyrophosphatase, Non-Canonical Purine NTP Pyrophosphatase, ITPase, Inosine Triphosphate Pyrophosphatase, Inosine Triphosphatase

Inosine Triphosphate Pyrophosphatase (ITPase) is a cytoplasmic enzyme that belongs to the HAM1 NTPase family. ITPase hydrolyzes the non-canonical purine nucleotides inosine triphosphate (ITP) and deoxyinosine triphosphate (dITP) to the monophosphate nucleotide (IMP) and diphosphate. The ITPase enzyme acts as a homodimer and does not distinguish between the deoxy- and ribose forms. ITPase probably excludes non-canonical purines from RNA and DNA precursor pools, thus preventing their incorporation into RNA and DNA and avoiding chromosomal lesions. Defects in ITPase is thought to be inherited and is characterized by an over-accumulation of ITP in erythocytes, leukocytes and fibroblasts.

规格价格库存数量
5 μg
¥ 693
6-8日内发货
10 μg
¥ 1,170
6-8日内发货
20 μg
¥ 1,860
5日内发货
50 μg
¥ 3,470
5日内发货
100 μg
¥ 4,930
5日内发货
200 μg
¥ 7,350
5日内发货
500 μg
¥ 12,100
5日内发货
1 mg
¥ 17,300
5日内发货
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产品介绍

生物活性
产品描述
Inosine Triphosphate Pyrophosphatase (ITPase) is a cytoplasmic enzyme that belongs to the HAM1 NTPase family. ITPase hydrolyzes the non-canonical purine nucleotides inosine triphosphate (ITP) and deoxyinosine triphosphate (dITP) to the monophosphate nucleotide (IMP) and diphosphate. The ITPase enzyme acts as a homodimer and does not distinguish between the deoxy- and ribose forms. ITPase probably excludes non-canonical purines from RNA and DNA precursor pools, thus preventing their incorporation into RNA and DNA and avoiding chromosomal lesions. Defects in ITPase is thought to be inherited and is characterized by an over-accumulation of ITP in erythocytes, leukocytes and fibroblasts.
生物活性
Activity has not been tested. It is theoretically active, but we cannot guarantee it. If you require protein activity, we recommend choosing the eukaryotic expression version first.
研究背景
Inosine Triphosphate Pyrophosphatase (ITPase) is a cytoplasmic enzyme that belongs to the HAM1 NTPase family. ITPase hydrolyzes the non-canonical purine nucleotides inosine triphosphate (ITP) and deoxyinosine triphosphate (dITP) to the monophosphate nucleotide (IMP) and diphosphate. The ITPase enzyme acts as a homodimer and does not distinguish between the deoxy- and ribose forms. ITPase probably excludes non-canonical purines from RNA and DNA precursor pools, thus preventing their incorporation into RNA and DNA and avoiding chromosomal lesions. Defects in ITPase is thought to be inherited and is characterized by an over-accumulation of ITP in erythocytes, leukocytes and fibroblasts.
种属
Human
表达系统
E. coli
标签C-6xHis
蛋白编号Q9BY32
氨基酸序列Ala2-Ala194
蛋白构建Ala2-Ala194
蛋白纯度
Greater than 95% as determined by reducing SDS-PAGE. (QC verified)
缓冲液Supplied as a 0.2 μm filtered solution of 20 mM Tris-HCl, 5% Trehalose, 300 mM NaCl, 30% Glycerol, 0.05% Tween 80, pH8.0.
别名Putative Oncog, Nucleoside-Triphosphate Pyrophosphatase, Nucleoside-Triphosphate Diphosphatase, NTPase, Non-Standard Purine NTP Pyrophosphatase, Non-Canonical Purine NTP Pyrophosphatase, ITPase, Inosine Triphosphate Pyrophosphatase, Inosine Triphosphatase
内毒素< 0.1 ng/µg (1 EU/µg) as determined by LAL test.
化学信息
分子量21 KDa (reducing condition)
储存&溶解度
运输方式In general, Lyophilized powders are shipping with blue ice. Solutions are shipping with dry ice.
存储Lyophilized powders can be stably stored for over 12 months, while liquid products can be stored for 6-12 months at -80°C. For reconstituted protein solutions, the solution can be stored at -20°C to -80°C for at least 3 months. Please avoid multiple freeze-thaw cycles and store products in aliquots.

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