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Anti-Endoglin/CD105 Antibody-FITC (5X880)
还可以产品编号 TMAY-00357F
Anti-Endoglin/CD105 Antibody-FITC (5X880) 是一种 FITC-conjugated Mouse 抗体，靶向 Endoglin/CD105。Anti-Endoglin/CD105 Antibody-FITC (5X880) 可用于 FCM。
Anti-Endoglin/CD105 Antibody-FITC (5X880)
Anti-Endoglin/CD105 Antibody-FITC (5X880)
还可以产品编号 TMAY-00357F
Anti-Endoglin/CD105 Antibody-FITC (5X880) 是一种 FITC-conjugated Mouse 抗体，靶向 Endoglin/CD105。Anti-Endoglin/CD105 Antibody-FITC (5X880) 可用于 FCM。
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产品介绍
生物活性
偶联与修饰
抗原信息
| 产品描述 | Anti-Endoglin/CD105 Antibody-FITC (5X880) is a FITC-conjugated Mouse antibody targeting Endoglin/CD105. Anti-Endoglin/CD105 Antibody-FITC (5X880) can be used in FCM. |
| Ig Type | Monoclonal Mouse IgG2b |
| 克隆号 | 5X880 |
| 交叉反应 | Human |
| 验证活性 | 1. Flow cytometric analysis of CD105 expression on human HUVEC cells. HUVEC cells (Human umbilical vein endothelial cells) were stained with FITC Mouse anti-Human CD105 antibody (solid line fluorescence histogram) or a negative control at a matching concentration; dashed line histogram) antibody. Flow cytometric fluorescence histograms were derived from gated events with the forward and side light-scatter characteristics of viable cells. 2. Flow cytometric analysis of CD105 expression on human HeLa cells. HeLa cells were stained with FITC Mouse anti-Human CD105 antibody (solid line fluorescence histogram) or a negative control at a matching concentration; dashed line histogram) antibody. Flow cytometric fluorescence histograms were derived from gated events with the forward and side light-scatter characteristics of viable cells. |
| 应用 | FCM |
| 推荐剂量 | 10 μl/Test, 0.1 mg/ml |
| 抗体种类 | Monoclonal |
| 宿主来源 | Mouse |
| 构建方式 | This antibody was produced from a hybridoma resulting from the fusion of a mouse myeloma with B cells obtained from a mouse immunized with purified, recombinant Human Endoglin / CD105 (rh CD105; TMPY-01384; Met 1-Gly 586; NP_001108225.1). The IgG fraction of the cell culture supernatant was purified by Protein A affinity chromatography and conjugated with FITC under optimum conditions, the unreacted FITC was removed . |
| 纯化方式 | Protein A |
| 性状 | Liquid |
| 缓冲液 | PBS solution containing 0.5% BSA and 0.09% sodium azide |
| 研究背景 | Endoglin, also known as CD105, is a type I homodimeric transmembrane glycoprotein with a large, disulfide-linked, extracellular region and a short, constitutively phosphorylated cytoplasmic tail. Endoglin contains an RGD tripeptide which is a key recognition structure in cellular adhesion,,suggesting a critical role for endoglin in the binding of endothelial cells to integrins and/or other RGD receptors. Endoglin is highly expressed on vascular endothelial cells, chondrocytes, and syncytiotrophoblasts of term placenta. It is also found on activated monocytes, mesenchymal stem cells and leukemic cells of lymphoid and myeloid lineages. As an accessory receptor for the TGF-β superfamily ligands, endoglin binds TGF-β1 and TGF-β3 with high affinity not by itself but by associating with TGF-β type II receptor (TβRII) and activates the downstream signal pathways. In addition, in human umbilical vein endothelial cells, ALK-1 is also a receptor kinase for endoglin threonine phosphorylation, and mutations in either of the two genes result in the autosomal-dominant vascular dysplasia, hereditary hemorrhagic telangiectasia (HHT). Endoglin has been regarded as a powerful biomarker of neovascularization, and is associated with several solid tumor types. |
| 偶联 | FITC |
| 其他可选修饰符 | Unconjugated/Biotin/HRP |
| 可提供抗体种类 | 4 |
| 免疫原 | Recombinant Human CD105 protein (TMPY-01384) |
| 抗原种属 | Human |
| 研究领域 | Hemangioblast Markers, Cancer Drug Targets |
存储&运输
| 储存方式 | Store at 2°C-8°C for 12 months, do not freeze. Keep away from direct sunlight. Sodium azide is toxic to cells and should be disposed of properly. Flush with large volumes of water during disposal. |
| 运输方式 | Shipping with blue ice. |
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比如您的给药剂量是 10 mg/kg ，每只动物体重 20 g ，给药体积 100 μL ， 
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