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Anti-Olig-1/Oligo1 Polyclonal Antibody

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货号 TMAB-01285

别名 Oligodendrocyte transcription factor 1, Oligodendrocyte specific bHLH transcription factor 1, Oligodendrocyte lineage transcription factor 1, Oligo1, Oligo 1, OLIG1, Olig 1, Class E basic helix-loop-helix protein 21, Class B basic helix-loop-helix protein 6, bHLHe21, BHLHB6, BHLHB 6, BHLH B6, Basic domain helix loop helix protein class B6, Basic domain helix loop helix protein class B 6

Anti-Olig-1/Oligo1 Polyclonal Antibody 是一种 Rabbit 抗体，靶向 Olig-1/Oligo1。Anti-Olig-1/Oligo1 Polyclonal Antibody 可用于 IF,IHC-Fr,IHC-P。

Anti-Olig-1/Oligo1 Polyclonal Antibody

Anti-Olig-1/Oligo1 Polyclonal Antibody

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货号 TMAB-01285 别名 Oligodendrocyte transcription factor 1, Oligodendrocyte specific bHLH transcription factor 1, Oligodendrocyte lineage transcription factor 1, Oligo1, Oligo 1, OLIG1, Olig 1, Class E basic helix-loop-helix protein 21, Class B basic helix-loop-helix protein 6, bHLHe21, BHLHB6, BHLHB 6, BHLH B6, Basic domain helix loop helix protein class B6, Basic domain helix loop helix protein class B 6

Anti-Olig-1/Oligo1 Polyclonal Antibody 是一种 Rabbit 抗体，靶向 Olig-1/Oligo1。Anti-Olig-1/Oligo1 Polyclonal Antibody 可用于 IF,IHC-Fr,IHC-P。

规格价格库存数量
50 μL
¥ 1,165
5日内发货
100 μL
¥ 1,965
5日内发货
200 μL
¥ 2,795
5日内发货
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产品介绍

生物活性
产品描述
Anti-Olig-1/Oligo1 Polyclonal Antibody is a Rabbit antibody targeting Olig-1/Oligo1. Anti-Olig-1/Oligo1 Polyclonal Antibody can be used in IF,IHC-Fr,IHC-P.
别名Oligodendrocyte transcription factor 1, Oligodendrocyte specific bHLH transcription factor 1, Oligodendrocyte lineage transcription factor 1, Oligo1, Oligo 1, OLIG1, Olig 1, Class E basic helix-loop-helix protein 21, Class B basic helix-loop-helix protein 6, bHLHe21, BHLHB6, BHLHB 6, BHLH B6, Basic domain helix loop helix protein class B6, Basic domain helix loop helix protein class B 6
Ig Type
IgG
反应种属
Human (predicted:Mouse,Rat,Dog,Pig,Cow)
验证活性
Paraformaldehyde-fixed, paraffin embedded (human brain glioma); Antigen retrieval by boiling in sodium citrate buffer (pH6.0) for 15 min; Block endogenous peroxidase by 3% hydrogen peroxide for 20 min; Blocking buffer (normal goat serum) at 37°C for 30 min; Incubation with (OLIG1) Polyclonal Antibody, Unconjugated (TMAB-01285) at 1:200 overnight at 4°C, followed by operating according to SP Kit (Rabbit) instructionsand DAB staining.
verifiedActivity
应用IFIHC-FrIHC-P
推荐剂量
IHC-P: 1:100-500; IHC-Fr: 1:100-500; IF: 1:50-200
抗体种类
Polyclonal
宿主来源Rabbit
亚细胞定位Nucleus.
组织特异性Expressed in the brain, in oligodendrocytes. Strongly expressed in oligodendrogliomas, while expression is weak to moderate in astrocytomas. Expression in glioblastomas is highly variable.
构建方式Polyclonal Antibody
纯化方式Protein A purified
性状Liquid
缓冲液0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
浓度1 mg/mL
研究背景The oligodendrocyte lineage-specific basic helix-loop-helix (OLIG) family of transcription factors include OLIG1-OLIG3, which differ in tissue expression. OLIG1 and OLIG2 are specifically expressed in nervous tissue as gene regulators of oligodendrogenesis. OLIG2 is more widely expressed in embryonic brain than OLIG1, while OLIG3 is primarily expressed in non-neural tissues. OLIG1 and OLIG2 interact with the Nkx-2.2 homeodomain protein, which is responsible for directing ventral neuronal patterning in response to graded Sonic hedgehog signaling in the embryonic neural tube. These interactions between OLIG proteins and Nkx-2.2 appear to promote the formation of alternate cell types by inhibiting V3 interneuron development. OLIG1 and OLIG2 are abundantly expressed in oligodendroglioma and nearly absent in astrocytomas. Therefore, OLIG proteins are candidates for molecular markers of human glial brain tumors, which are the most common primary malignancies of the human brain.
抗原信息
免疫原
KLH conjugated synthetic peptide: human OLIG1
抗原种属
Human
基因名称
OLIG1
基因ID
116448
蛋白名称
Oligodendrocyte transcription factor 1
Uniprot ID
Q8TAK6
研究领域
Neurogenesis,Oligodendrocyte marker
功能
romotes formation and maturation of oligodendrocytes, especially within the brain. Cooperates with OLIG2 to establish the pMN domain of the embryonic neural tube (By similarity).
化学信息
分子量Theoretical: 28 kDa.
储存&溶解度
储存方式Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles.
运输方式Shipping with blue ice.
存储store at low temperature | store at -20°C

计算器

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