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Anti-Endoglin/CD105 Antibody (4U678)
还可以产品编号 TMAY-00361
Anti-Endoglin/CD105 Antibody (4U678) 是一种 Rabbit 抗体，靶向 Endoglin/CD105。Anti-Endoglin/CD105 Antibody (4U678) 可用于 FCM,ICC/IF。
Anti-Endoglin/CD105 Antibody (4U678)
Anti-Endoglin/CD105 Antibody (4U678)
还可以产品编号 TMAY-00361
Anti-Endoglin/CD105 Antibody (4U678) 是一种 Rabbit 抗体，靶向 Endoglin/CD105。Anti-Endoglin/CD105 Antibody (4U678) 可用于 FCM,ICC/IF。
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偶联与修饰
抗原信息
| 产品描述 | Anti-Endoglin/CD105 Antibody (4U678) is a Rabbit antibody targeting Endoglin/CD105. Anti-Endoglin/CD105 Antibody (4U678) can be used in FCM,ICC/IF. |
| Ig Type | Monoclonal Rabbit IgG |
| 克隆号 | 4U678 |
| 交叉反应 | Human |
| 验证活性 | 1. Immunofluorescence staining of Human CD105 in MSC cells. Cells were fixed with 4% PFA, blocked with 10% serum, and incubated with rabbit anti-Human CD105 monoclonal antibody (1:60) at 37°C 1 hour. Then cells were stained with the Alexa Fluor® 488-conjugated goat Anti-rabbit IgG secondary antibody (green) and counterstained with DAPI (blue). Positive staining was localized to cell membrane. 2. Flow cytometric analysis of Human CD105 expression in HeLa cells. |
| 应用 | FCM,ICC/IF |
| 推荐剂量 | ICC-IF: 1:20-1:100; FCM: 1:25-1:100 |
| 抗体种类 | Monoclonal |
| 宿主来源 | Rabbit |
| 构建方式 | This antibody was obtained from a rabbit immunized with purified, recombinant Human Endoglin / CD105 (rh Endoglin / CD105 ; TMPY-01384; NP_001108225.1; Met1-Gly586). |
| 纯化方式 | Protein A |
| 性状 | Liquid |
| 缓冲液 | 0.2 μm filtered solution in PBS |
| 研究背景 | Endoglin, also known as CD105, is a type I homodimeric transmembrane glycoprotein with a large, disulfide-linked, extracellular region and a short, constitutively phosphorylated cytoplasmic tail. Endoglin contains an RGD tripeptide which is a key recognition structure in cellular adhesion,,suggesting a critical role for endoglin in the binding of endothelial cells to integrins and/or other RGD receptors. Endoglin is highly expressed on vascular endothelial cells, chondrocytes, and syncytiotrophoblasts of term placenta. It is also found on activated monocytes, mesenchymal stem cells and leukemic cells of lymphoid and myeloid lineages. As an accessory receptor for the TGF-β superfamily ligands, endoglin binds TGF-β1 and TGF-β3 with high affinity not by itself but by associating with TGF-β type II receptor (TβRII) and activates the downstream signal pathways. In addition, in human umbilical vein endothelial cells, ALK-1 is also a receptor kinase for endoglin threonine phosphorylation, and mutations in either of the two genes result in the autosomal-dominant vascular dysplasia, hereditary hemorrhagic telangiectasia (HHT). Endoglin has been regarded as a powerful biomarker of neovascularization, and is associated with several solid tumor types. |
| 偶联 | Unconjugated |
| 其他可选修饰符 | APC/PerCP/FITC/PE |
| 可提供抗体种类 | 5 |
| 免疫原 | Recombinant Human Endoglin / CD105 protein (TMPY-01384) |
| 抗原种属 | Human |
| 研究领域 | Hemangioblast Markers, Cancer Drug Targets |
存储&运输
| 储存方式 | Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. Preservative-Free. |
| 运输方式 | Shipping with blue ice. |
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比如您的给药剂量是 10 mg/kg ，每只动物体重 20 g ，给药体积 100 μL ， 
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