Anti-ACCN2 Polyclonal Antibody is a Rabbit antibody targeting ACCN2. Anti-ACCN2 Polyclonal Antibody can be used in WB.

IgG

Human,Mouse,Rat (predicted:Chicken,Cow,Horse)

1. Sample:
Cerebrum (Mouse) Lysate at 40 μg
Cerebrum (Rat) Lysate at 40 μg
Primary: Anti-ACCN2 (TMAB-00030) at 1/500 dilution
Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution
Predicted band size: 58 kDa
Observed band size: 63 kDa
2. Sample:
Lane 1: Human SH-SY5Y cell lysates
Lane 2: Human 293T cell lysates
Lane 3: Human HL-60 cell lysates
Lane 4: Human U87MG cell lysates
Primary: Anti-ACCN2 (TMAB-00030) at 1/1000 dilution
Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution
Predicted band size: 58 kDa
Observed band size: 60 kDa

WB: 1:500-2000

Polyclonal

KLH conjugated synthetic peptide: human ASIC1

Human

ASIC1

Acid-sensing ion channel 1

Sodium Channels

Cation channel with high affinity for sodium, which is gated by extracellular protons and inhibited by the diuretic amiloride. Also permeable for Ca(2+), Li(+) and K(+). Generates a biphasic current with a fast inactivating and a slow sustained phase. Mediates glutamate-independent Ca(2+) entry into neurons upon acidosis. This Ca(2+) overloading is toxic for cortical neurons and may be in part responsible for ischemic brain injury. Heteromeric channel assembly seems to modulate channel properties. Functions as a postsynaptic proton receptor that influences intracellular Ca(2+) concentration and calmodulin-dependent protein kinase II phosphorylation and thereby the density of dendritic spines. Modulates activity in the circuits underlying innate fear.