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Anti-ITGAV Antibody (4Q604)

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Anti-ITGAV Antibody (4Q604)
产品编号 TMAH-00647
别名 VTNR, VNRA, Vitronectin receptor subunit alpha, Vitronectin receptor, MSK8, Integrin alpha-V, CD antigen CD51

Anti-ITGAV Antibody (4Q604) 是一种抗体，靶向 ITGAV。Anti-ITGAV Antibody (4Q604) 可用于 ELISA, WB, IHC。

Anti-ITGAV Antibody (4Q604)

Anti-ITGAV Antibody (4Q604)

Rating icon 还可以
Anti-ITGAV Antibody (4Q604)
产品编号 TMAH-00647 别名 VTNR, VNRA, Vitronectin receptor subunit alpha, Vitronectin receptor, MSK8, Integrin alpha-V, CD antigen CD51

Anti-ITGAV Antibody (4Q604) 是一种抗体，靶向 ITGAV。Anti-ITGAV Antibody (4Q604) 可用于 ELISA, WB, IHC。

规格价格库存数量
50 μL
¥ 1,315
5日内发货
100 μL
¥ 2,195
5日内发货
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产品介绍

生物活性
产品描述
Anti-ITGAV Antibody (4Q604) is an antibody targeting ITGAV. Anti-ITGAV Antibody (4Q604) can be used in ELISA, WB, IHC.
别名VTNR, VNRA, Vitronectin receptor subunit alpha, Vitronectin receptor, MSK8, Integrin alpha-V, CD antigen CD51
Ig Type
Rabbit IgG
克隆号
4Q604
交叉反应
Human
验证活性
1. Western Blot
-Positive WB detected in: U-251 whole cell lysate, Hela whole cell lysate, HepG2 whole cell lysate
-All lanes: ITGAV antibody at 1:1000
-Secondary: Goat polyclonal to rabbit IgG at 1/50000 dilution
-Predicted band size: 117, 113, 112 kDa
-Observed band size: 130 kDa
2. IHC image of TMAH-00647 diluted at 1:100 and staining in paraffin-embedded human placenta tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a Goat anti-rabbit IgG polymer labeled by HRP and visualized using 0.05% DAB.
应用
ELISA, WB, IHC
推荐剂量
WB:1:500-1:5000; IHC:1:50-1:200.
抗体种类
Monoclonal
亚细胞定位Cell membrane; Single-pass type I membrane protein. Cell junction, focal adhesion.
构建方式Recombinant Antibody
纯化方式Affinity-chromatography
性状Liquid
缓冲液Phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
研究背景The alpha-V (ITGAV) integrins are receptors for vitronectin, cytotactin, fibronectin, fibrinogen, laminin, matrix metalloproteinase-2, osteopontin, osteomodulin, prothrombin, thrombospondin and vWF. They recognize the sequence R-G-D in a wide array of ligands. ITGAV:ITGB3 binds to fractalkine (CX3CL1) and may act as its coreceptor in CX3CR1-dependent fractalkine signaling. ITGAV:ITGB3 binds to NRG1 (via EGF domain) and this binding is essential for NRG1-ERBB signaling. ITGAV:ITGB3 binds to FGF1 and this binding is essential for FGF1 signaling. ITGAV:ITGB3 binds to FGF2 and this binding is essential for FGF2 signaling. ITGAV:ITGB3 binds to IGF1 and this binding is essential for IGF1 signaling. ITGAV:ITGB3 binds to IGF2 and this binding is essential for IGF2 signaling. ITGAV:ITGB3 binds to IL1B and this binding is essential for IL1B signaling. ITGAV:ITGB3 binds to PLA2G2A via a site (site 2) which is distinct from the classical ligand-binding site (site 1) and this induces integrin conformational changes and enhanced ligand binding to site 1. ITGAV:ITGB3 and ITGAV:ITGB6 act as a receptor for fibrillin-1 (FBN1) and mediate R-G-D-dependent cell adhesion to FBN1. Integrin alpha-V/beta-6 or alpha-V/beta-8 (ITGAV:ITGB6 or ITGAV:ITGB8) mediates R-G-D-dependent release of transforming growth factor beta-1 (TGF-beta-1) from regulatory Latency-associated peptide (LAP), thereby playing a key role in TGF-beta-1 activation. ITGAV:ITGB3 act as a receptor for CD40LG. (Microbial infection) Integrin ITGAV:ITGB5 acts as a receptor for Adenovirus type C. (Microbial infection) Integrin ITGAV:ITGB5 and ITGAV:ITGB3 act as receptors for Coxsackievirus A9 and B1. (Microbial infection) Integrin ITGAV:ITGB3 acts as a receptor for Herpes virus 8/HHV-8. (Microbial infection) Integrin ITGAV:ITGB6 acts as a receptor for herpes simplex 1/HHV-1. (Microbial infection) Integrin ITGAV:ITGB3 acts as a receptor for Human parechovirus 1. (Microbial infection) Integrin ITGAV:ITGB3 acts as a receptor for West nile virus. (Microbial infection) In case of HIV-1 infection, the interaction with extracellular viral Tat protein seems to enhance angiogenesis in Kaposi's sarcoma lesions.
偶联与修饰
偶联
Unconjugated
抗原信息
免疫原
A synthetic peptide: Human Integrin alpha V
抗原种属
Human
基因ID
3685
Uniprot ID
研究领域
Cancer, Cardiovascular, Microbiology, Signal transduction, Stem cells
存储&运输
储存方式Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles.
运输方式Shipping with blue ice.

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