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Anti-Pirh2 Antibody (1B789) 是一种 Mouse 抗体,靶向 Pirh2。Anti-Pirh2 Antibody (1B789) 可用于 WB,ICC,IHC,FCM。
Anti-Pirh2 Antibody (1B789) 是一种 Mouse 抗体,靶向 Pirh2。Anti-Pirh2 Antibody (1B789) 可用于 WB,ICC,IHC,FCM。
规格 | 价格 | 库存 | 数量 |
---|---|---|---|
50 μL | ¥ 1,995 | 5日内发货 | |
100 μL | ¥ 2,980 | 5日内发货 |
产品描述 | Anti-Pirh2 Antibody (1B789) is a Mouse antibody targeting Pirh2. Anti-Pirh2 Antibody (1B789) can be used in WB,ICC,IHC,FCM. |
别名 | ZNF363, ZN363_HUMAN, Zinc finger protein 363, zinc finger CHY type, ZFP 363, ZCHY, RNF199, RING finger protein 199, RING finger and CHY zinc finger domain-containing protein 1, Ring finger and CHY zinc finger domain containing 1 E3 ubiquitin protein ligase, RCHY1, PRO1996, PIRH2F, PIRH2E, Pirh 2, p53-induced RING-H2 protein, p53 induced protein with a RING H2 domain, hPirh2, hARNIP, E3 ubiquitin-protein ligase Pirh2, CH-rich-interacting match with PLAG1, CHIMP, ARNIP, Androgen receptor N-terminal-interacting protein, Androgen receptor N terminal interacting protein |
交叉反应 | Human,Rat |
应用 | |
推荐剂量 | WB: 1:500-1000; IHC: 1:50-200; ICC: 1:50-200; FCM: 1:100-200 |
抗体种类 | Monoclonal |
宿主来源 | Mouse |
构建方式 | Hybridoma Monoclonal Antibody |
纯化方式 | ProA affinity purified |
性状 | Liquid |
缓冲液 | 1*TBS (pH7.4), 1%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide. |
研究背景 | Pirh2, also known as Androgen receptor N-terminal-interacting protein (ARNIP), ZN363 or CHIMP, has p53-induced ubiquitin-protein ligase activity, promoting p53 degradation. The protein physically interacts with p53 and the resulting degradation of p53 renders Pirh2 an oncogenic protein as the loss of p53 function contributes to malignant tumor development. The gene encoding for the protein maps to chromosome 4q21.1 and transcription of this gene is regulated by p53. Pirh2 expression decreases the level of p53 and a decrease of endogenous Pirh2 expression ups p53 levels. Pirh2 is therefore considered, together with MDM2, to be acting as a negative regulator of p53 function. |
偶联 | Unconjugated |
免疫原 | Recombinant Protein |
Uniprot ID |
分子量 | Theoretical: 30 kDa. |
储存方式 | Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. |
运输方式 | Shipping with blue ice. |
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