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Anti-ARMET/MANF Antibody (1O944)
还可以产品编号 TMAY-03497
Anti-ARMET/MANF Antibody (1O944) 是一种 Rabbit 抗体，靶向 ARMET/MANF。Anti-ARMET/MANF Antibody (1O944) 可用于 ELISA。
Anti-ARMET/MANF Antibody (1O944)
Anti-ARMET/MANF Antibody (1O944)
还可以产品编号 TMAY-03497
Anti-ARMET/MANF Antibody (1O944) 是一种 Rabbit 抗体，靶向 ARMET/MANF。Anti-ARMET/MANF Antibody (1O944) 可用于 ELISA。
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产品介绍
生物活性
偶联与修饰
抗原信息
| 产品描述 | Anti-ARMET/MANF Antibody (1O944) is a Rabbit antibody targeting ARMET/MANF. Anti-ARMET/MANF Antibody (1O944) can be used in ELISA. |
| Ig Type | Monoclonal Rabbit IgG |
| 克隆号 | 1O944 |
| 交叉反应 | Mouse |
| 应用 | ELISA |
| 推荐剂量 | ELISA: 1:5000-1:10000 |
| 抗体种类 | Monoclonal |
| 宿主来源 | Rabbit |
| 构建方式 | This antibody was obtained from a rabbit immunized with purified, recombinant Mouse MANF (TMPY-02732; NP_083379.2; Met1-Leu179). |
| 纯化方式 | Protein A |
| 性状 | Liquid |
| 缓冲液 | 0.2 μm filtered solution in PBS |
| 研究背景 | Mesencephalic astrocyte-derived neurotrophic factor, also known as Protein ARMET, Arginine-rich protein, MANF, and ARMET, is a secreted protein that belongs to the ARMET family. ARMET selectively promotes the survival of dopaminergic neurons of the ventral midbrain. It modulates GABAergic transmission to the dopaminergic neurons of the substantia nigra. ARMET enhances spontaneous, as well as evoked, GABAergic inhibitory postsynaptic currents in dopaminergic neurons. ARMET inhibits cell proliferation and endoplasmic reticulum (ER) stress-induced cell death. The N-terminal region of ARMET may be responsible for neurotrophic activity while the C-terminal region may play a role in the ER stress response. MANF reduces endoplasmic reticulum (ER) stress and has neurotrophic effects on dopaminergic neurons. Intracortical delivery of recombinant MANF protein protects tissue from ischemic brain injury. MANF has been described as a survival factor for dopaminergic neurons. MANF expression was widespread in the nervous system and non-neuronal tissues. In the brain, relatively high MANF levels were detected in the cerebral cortex, hippocampus, and cerebellar Purkinje cells. The widespread expression of MANF together with its evolutionary conserved nature and regulation by brain insults suggests that it has important functions both under normal and pathological conditions in many tissue types. |
| 偶联 | Unconjugated |
| 免疫原 | Recombinant Mouse MANF protein (TMPY-02732) |
| 抗原种属 | Mouse |
存储&运输
| 储存方式 | Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. Preservative-Free. |
| 运输方式 | Shipping with blue ice. |
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计算器
比如您的给药剂量是 10 mg/kg ，每只动物体重 20 g ，给药体积 100 μL ， 
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