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顶部产品介绍抗原信息化学信息储存和溶解信息计算器

Anti-BMP-1 Polyclonal Antibody

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货号 TMAB-00240

别名 Procollagen C-proteinase (PCP), PCOLC, Mammalian tolloid protein (mTld), Bone morphogenetic protein 1, BMP-1, BMP1

Anti-BMP-1 Polyclonal Antibody 是一种 Rabbit 抗体，靶向 BMP-1。Anti-BMP-1 Polyclonal Antibody 可用于 IF,IHC-Fr,IHC-P,WB。

Anti-BMP-1 Polyclonal Antibody

Anti-BMP-1 Polyclonal Antibody

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货号 TMAB-00240 别名 Procollagen C-proteinase (PCP), PCOLC, Mammalian tolloid protein (mTld), Bone morphogenetic protein 1, BMP-1, BMP1

Anti-BMP-1 Polyclonal Antibody 是一种 Rabbit 抗体，靶向 BMP-1。Anti-BMP-1 Polyclonal Antibody 可用于 IF,IHC-Fr,IHC-P,WB。

规格价格库存数量
50 μL
¥ 1,165
5日内发货
100 μL
¥ 1,960
5日内发货
200 μL
¥ 2,790
5日内发货
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产品介绍

生物活性
产品描述
Anti-BMP-1 Polyclonal Antibody is a Rabbit antibody targeting BMP-1. Anti-BMP-1 Polyclonal Antibody can be used in IF,IHC-Fr,IHC-P,WB.
别名Procollagen C-proteinase (PCP), PCOLC, Mammalian tolloid protein (mTld), Bone morphogenetic protein 1, BMP-1, BMP1
Ig Type
IgG
反应种属
Human,Mouse,Rat (predicted:Dog,Pig,Cow,Horse,Rabbit)
验证活性
1. Tissue/cell: Rat adrenal gland; 4% Paraformaldehyde-fixed and paraffin-embedded;
Antigen retrieval: citrate buffer (0.01M, pH6.0), Boiling bathing for 15 min; Block endogenous peroxidase by 3% Hydrogen peroxide for 30 min; Blocking buffer (normal goat serum) at 37°C for 20 min;
Incubation: Anti-BMP1 Polyclonal Antibody, Unconjugated (TMAB-00240) 1:500, overnight at 4°C, followed by conjugation to the secondary antibody and DAb staining.
2. Sample: Liver (Mouse) Lysate at 40 μg
Primary: Anti-BMP1 (TMAB-00240) at 1/300 dilution
Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution
Predicted band size: 98 kDa
Observed band size: 98 kDa
3. Sample:
Lane 1: Mouse Placenta tissue lysates
Lane 2: Mouse Cerebrum tissue lysates
Lane 3: Mouse NIH/3T3 cell lysates
Lane 4: Rat Placenta tissue lysates
Lane 5: Human HeLa cell lysates
Lane 6: Human A549 cell lysates
Primary: Anti-BMP1 (TMAB-00240) at 1/1000 dilution
Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution
Predicted band size: 98 kDa
Observed band size: 100 kDa
verifiedActivityverifiedActivityverifiedActivity
应用IFIHC-FrIHC-PWB
推荐剂量
WB: 1:500-2000; IHC-P: 1:100-500; IHC-Fr: 1:100-500; IF: 1:100-500
抗体种类
Polyclonal
宿主来源Rabbit
组织特异性Ubiquitous.
构建方式Polyclonal Antibody
纯化方式Protein A purified
性状Liquid
缓冲液0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
浓度1 mg/mL
研究背景Bone morphogenetic protein 1 (BMP1) was first identified in osteogenic extracts of bone. It is an extracellular zinc endopeptidase, implicated in morphogenetic processes in a broad range of species. BMP1 is a member of the astacin family of metalloproteinases. The astacin family includes BMP1, astacin, meprin A and B, tolloid-like proteins, and choriolysin. BMP1 is involved in extracellular matrix (ECM) formation, suggesting that a functional link may exist between astacin metalloproteinases, growth factors, and cell differentiation and pattern formation during development. The name PCP reflects this enzyme’s involvement in the collagen deposition of growing bone. The enzymes known as the procollagen C and N proteinases (PCP and PNP) are involved in the processing of fibrillar procollagen precursors to mature collagens, which is an essential requirement for fibril formation. PCP cleaves the C-terminus from procollagen, to allow the formation of mature, triplehelical collagen. The N-terminus is cleaved by the procollagen N-proteinase (PNP or ADAM-TS2). Defects in PNP have been linked to the skin disorder dermatosparaxis, and defects in BMP1 are thought to lead to aberrant collagen processing, and connective tissue disorders. Many forms of BMP1 have been reported, with varying truncation at the C-terminus. The long form of BMP1 is most similar to the tolloid-like proteins, which have extra EGF-like and CUB domains.
抗原信息
免疫原
KLH conjugated synthetic peptide: human BMP1
抗原种属
Human
基因名称
BMP1
基因ID
649
蛋白名称
Bone morphogenetic protein 1
Uniprot ID
P13497
研究领域
Metabolism of lipids and lipoproteins,Cell differentiation,BMPs,Lipid metabolism,MMP,Collagen,Bone
功能
Cleaves the C-terminal propeptides of procollagen I, II and III. Induces cartilage and bone formation. May participate in dorsoventral patterning during early development by cleaving chordin (CHRD).
化学信息
分子量Theoretical: 98 kDa.
储存&溶解度
储存方式Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles.
运输方式Shipping with blue ice.

计算器

  • 稀释 计算器
  • 配液 计算器

关键词

PCPmTldBMP 1
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