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顶部产品介绍抗原信息化学信息储存和溶解信息计算器

Anti-Repulsive Guidance Molecule B Polyclonal Antibody

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货号 TMAB-12196

Anti-Repulsive Guidance Molecule B Polyclonal Antibody 是一种 Rabbit 抗体，靶向 Repulsive Guidance Molecule B。Anti-Repulsive Guidance Molecule B Polyclonal Antibody 可用于 WB。

Anti-Repulsive Guidance Molecule B Polyclonal Antibody

Anti-Repulsive Guidance Molecule B Polyclonal Antibody

一键复制产品信息
Rating icon 还可以
货号 TMAB-12196

Anti-Repulsive Guidance Molecule B Polyclonal Antibody 是一种 Rabbit 抗体，靶向 Repulsive Guidance Molecule B。Anti-Repulsive Guidance Molecule B Polyclonal Antibody 可用于 WB。

规格价格库存数量
50 μL
¥ 1,160
5日内发货
100 μL
¥ 1,965
5日内发货
200 μL
¥ 2,785
5日内发货
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产品介绍

生物活性
产品描述
Anti-Repulsive Guidance Molecule B Polyclonal Antibody is a Rabbit antibody targeting Repulsive Guidance Molecule B. Anti-Repulsive Guidance Molecule B Polyclonal Antibody can be used in WB.
Ig Type
IgG
反应种属
Human,Mouse,Rat (predicted:Dog,Pig,Cow,Horse)
应用WB
推荐剂量
WB: 1:500-2000
抗体种类
Polyclonal
宿主来源Rabbit
亚细胞定位Cell membrane; Lipid-anchor, GPI-anchor (By similarity). Membrane raft
构建方式Hybridoma Polyclonal Antibody
纯化方式Protein A purified
性状Liquid
缓冲液0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
浓度1mg/ml
研究背景The repulsive guidance molecule (RGM) family of proteins are important in the guidance of growth cones of developing neurons. They are repulsive for a group of axons, those from the temporal half of the retina. RGM have been implicated in both axonal guidance and neural tube closure but as opposed to for ephrins, semaphorins, netrins and slits, no receptor mechanism for RGM activation has been defined. Dorsal root ganglion axons do not respond to RGM but neogenin (a netrin-binding protein which can function as an RGM receptor) expression can spur RGM responsiveness. The RGM proteins are attached to the membrane by a GPI-anchor. Two members of this family, RGMa and RGMb, are expressed in the nervous system. RGMc, also known as Hemojuvelin, is a part of the signaling pathway activating hepcidin and works together with hepcidin to restrict iron absorption in the gut. Defects in the gene encoding for RGMc causes the autosomal recessive disorder juvenile hemochromatosis (JH).
抗原信息
免疫原
KLH conjugated synthetic peptide: human RGMB
抗原种属
Human
基因名称
RGMB
基因ID
285704
蛋白名称
RGM domain family member B
Uniprot ID
Q6NW40
功能
Member of the repulsive guidance molecule (RGM) family that contributes to the patterning of the developing nervous system (By similarity). Acts as a bone morphogenetic protein (BMP) coreceptor that potentiates BMP signaling (By similarity). Promotes neuronal adhesion (By similarity). May inhibit neurite outgrowth.
化学信息
分子量Theoretical: 40 kDa.
储存&溶解度
储存方式Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles.
运输方式Shipping with blue ice.
存储store at low temperature | -20°C for 1 year

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