UBE2K Protein, Human, Recombinant (His & SUMO) is expressed in E. coli expression system with N-6xHis and SUMO tag. The predicted molecular weight is 38 KDa and the accession number is P61086.
规格 | 价格/CNY | 货期 | 数量 | |
---|---|---|---|---|
10 μg | ¥ 220 | 5日内发货 | ||
50 μg | ¥ 700 | 5日内发货 | ||
500 μg | ¥ 4,740 | 5日内发货 | ||
1 mg | ¥ 7,510 | 5日内发货 |
产品描述 | UBE2K Protein, Human, Recombinant (His & SUMO) is expressed in E. coli expression system with N-6xHis and SUMO tag. The predicted molecular weight is 38 KDa and the accession number is P61086. |
种属 | Human |
表达系统 | E. coli |
标签 | N-6xHis, SUMO |
蛋白编号 | P61086 |
别名 | Ubiquitin-Conjugating Enzyme E2-25 kDa, Huntingtin-Interacting Protein 2, Ubiquitin-Conjugating Enzyme E2-25K, HIP-2, Ubiquitin Carrier Protein, HIP2, Ubiquitin-Protein Ligase, Ubiquitin-Conjugating Enzyme E2 K, Ubiquitin-Conjugating Enzyme E2(25K), UBE2K |
氨基酸序列 | Met1-Asn200 |
蛋白构建 | Met1-Asn200 |
蛋白纯度 | Greater than 90% as determined by reducing SDS-PAGE. (QC verified) |
分子量 | 38 KDa (reducing condition) |
内毒素 | < 1 EU/μg by the LAL method. |
缓冲液 | Supplied as a 0.2 μm filtered solution of 20 mM PB, 8% Sucrose, 100 mM NaCl, 0.05% Tween 80, pH 7.5. |
存储 |
Lyophilized powders can be stably stored for over 12 months, while liquid products can be stored for 6-12 months at-80℃. For reconstituted proteinsolutions, the solution can be stored at -20°c to -80'c for at least 3 months. Please avoid multiple freeze-thaw cycles and store products in aliquots. |
运输方式 |
In general, Lyophilized powders are shipping with blue ice. Solutions are shipping with dry ice. |
研究背景 | Ubiquitin-Conjugating Enzyme E2 K (UBE2K) belongs to the E2 Ubiquitin-Conjugating Enzyme family. UBE2K is highly expressed in the brain, with highest levels found in cortex and striatum, and at lower levels in cerebellum and brainstem. UBE2K may mediate foam cell formation by the suppression of apoptosis of lipid-bearing macrophages through ubiquitination and subsequence degradation of p53/TP53. UBE2K is associated with the selective degradation of short-lived and abnormal proteins, such as the endoplasmic reticulum-associated degradation (ERAD) of misfolded lumenal proteins. In addition, UBE2K is involved in Alzheimer's disease, Huntington's disease and antigen processing through its interaction with huntingtin, and MHC-heavy chain proteins. |
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UBE2K Protein, Human, Recombinant (His & SUMO) Ubiquitin-Conjugating Enzyme E2-25 kDa Huntingtin-Interacting Protein 2 Ubiquitin-Conjugating Enzyme E2-25K HIP-2 Ubiquitin Carrier Protein HIP2 Ubiquitin-Protein Ligase Ubiquitin-Conjugating Enzyme E2 K Ubiquitin-Conjugating Enzyme E2(25K) HIP 2 UBE2K recombinant recombinant-proteins proteins protein