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PCSK9 Protein, Human, Recombinant (His)

产品编号 TMPY-00895

PCSK9 Protein, Human, Recombinant (His) is expressed in HEK293 Cells. The accession number is Q8NBP7-1.

PCSK9 Protein, Human, Recombinant (His)

产品编号 TMPY-00895

PCSK9 Protein, Human, Recombinant (His) is expressed in HEK293 Cells. The accession number is Q8NBP7-1.

规格	价格	库存	数量
50 μg	¥ 3,380	In stock
500 μg	¥ 12,300	In stock

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产品信息

生物活性	Immobilized Human PCSK9, His Tag at 2 μg/ml (100 μl/Well) on the plate. Dose response curve for Anti-PCSK9 antibody, hFc Tag with the EC50 of 0.13 μg/ml determined by ELISA (QC Test). Human LDLR, His Tag immobilized on CM5 Chip can bind Human PCSK9, His Tag with an affinity constant of 0.35 nM as determined in SPR assay (Biacore T200).
产品描述	PCSK9 Protein, Human, Recombinant (His) is expressed in HEK293 Cells. The accession number is Q8NBP7-1.
种属	Human
表达系统	HEK293 Cells
标签	C-His
蛋白编号	Q8NBP7-1
别名	Proprotein convertase subtilisin/kexin type 9,PCSK9,NARC1
蛋白构建	Gln31-Gln692
蛋白纯度	> 95% as determined by Bis-Tris PAGE; > 95% as determined by HPLC
分子量	Due to autocatalytic cleavage, the protein release the pro-form (59 kDa) and mature form (14 kDa). Due to glycosylation, the protein migrates to 65-68 kDa (pro-form) and 15kDa (mature form) based on Bis-Tris PAGE result.
内毒素	< 1.0 EU per μg protein as determined by the LAL method.
缓冲液	Supplied as 0.22μm filtered solution in 20mM PB, 300mM NaCl, 10% Glycerol (pH 7.4).
存储	Lyophilized powders can be stably stored for over 12 months, while liquid products can be stored for 6-12 months at -80°C. For reconstituted protein solutions, the solution can be stored at -20°C to -80°C for at least 3 months. Please avoid multiple freeze-thaw cycles and store products in aliquots.
运输方式	In general, Lyophilized powders are shipping with blue ice. Solutions are shipping with dry ice.
研究背景	Human Proprotein Convertase Subtilisin/Kexin Type 9 (PCSK9) is a secretory subtilase belonging to the proteinase K subfamily. PCSK9 is synthesized as a soluble zymogen that undergoes autocatalytic intramolecular processing in the ER , the pro domain and mature chain secrete together through noncovalent interactions. PCSK9 binds with low-density lipoprotein receptor (LDLR) and plays a major regulatory role in cholesterol homeostasis. Inhibition of PCSK9 function by preventing PCSK9/LDLR interaction is currently being explored as a means of lowering cholesterol levels. PCSK9 also binds to apolipoprotein receptor 2 (ApoER2), and play a role in the neural development.