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Anti-KDM5A Antibody (8P685)
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产品编号 TMAC-02302
别名 Retinoblastoma-binding protein 2, Retinoblastoma binding protein 2, RBP2, RBBP-2, RBBP2, Lysine-specific demethylase 5A, KDM5A_HUMAN, Kdm 5a, Jumonji/ARID domain-containing protein 1A, Jumonji/ARID domain containing protein 1A, JARID1A, Histone demethylase JARID1A
Anti-KDM5A Antibody (8P685) 是一种 Rabbit 抗体，靶向 KDM5A。Anti-KDM5A Antibody (8P685) 可用于 WB,ICC,IF,FCM。
Anti-KDM5A Antibody (8P685)
Anti-KDM5A Antibody (8P685)
还可以产品编号 TMAC-02302 别名 Retinoblastoma-binding protein 2, Retinoblastoma binding protein 2, RBP2, RBBP-2, RBBP2, Lysine-specific demethylase 5A, KDM5A_HUMAN, Kdm 5a, Jumonji/ARID domain-containing protein 1A, Jumonji/ARID domain containing protein 1A, JARID1A, Histone demethylase JARID1A
Anti-KDM5A Antibody (8P685) 是一种 Rabbit 抗体，靶向 KDM5A。Anti-KDM5A Antibody (8P685) 可用于 WB,ICC,IF,FCM。
| 规格 | 价格 | 库存 | 数量 |
|---|---|---|---|
| 50 μL | ¥ 1,480 | 5日内发货 | |
| 100 μL | ¥ 2,490 | 5日内发货 |
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产品介绍
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偶联与修饰
抗原信息
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| 产品描述 | Anti-KDM5A Antibody (8P685) is a Rabbit antibody targeting KDM5A. Anti-KDM5A Antibody (8P685) can be used in WB,ICC,IF,FCM. |
| 别名 | Retinoblastoma-binding protein 2, Retinoblastoma binding protein 2, RBP2, RBBP-2, RBBP2, Lysine-specific demethylase 5A, KDM5A_HUMAN, Kdm 5a, Jumonji/ARID domain-containing protein 1A, Jumonji/ARID domain containing protein 1A, JARID1A, Histone demethylase JARID1A |
| Ig Type | IgG |
| 克隆号 | 8P685 |
| 交叉反应 | Human,Mouse |
| 验证活性 | 1. Western blot analysis of KDM5A on A549 cell using anti-KDM5A antibody at 1/500 dilution. 2. ICC staining KDM5A in A549 cells (green). The nuclear counter stain is DAPI (blue). Cells were fixed in paraformaldehyde, permeabilised with 0.25% Triton X100/PBS. 3. ICC staining KDM5A in SiHa cells (green). The nuclear counter stain is DAPI (blue). Cells were fixed in paraformaldehyde, permeabilised with 0.25% Triton X100/PBS. 4. Flow cytometric analysis of SH-SY-5Y cells with KDM5A antibody at 1/100 dilution (red) compared with an unlabelled control (cells without incubation with primary antibody; black). Alexa Fluor 488-conjugated goat anti-rabbit IgG was used as the secondary antibody. |
| 应用 | |
| 推荐剂量 | WB: 1:500; ICC: 1:50-400; FCM: 1:50-100 |
| 抗体种类 | Monoclonal |
| 宿主来源 | Rabbit |
| 构建方式 | Recombinant Antibody |
| 纯化方式 | ProA affinity purified |
| 性状 | Liquid |
| 缓冲液 | 1*TBS (pH7.4), 1%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide. |
| 研究背景 | Histone demethylase that specifically demethylates 'Lys-4' of histone H3, thereby playing a central role in histone code. Does not demethylate histone H3 'Lys-9', H3 'Lys-27', H3 'Lys-36', H3 'Lys-79' or H4 'Lys-20'. Demethylates trimethylated and dimethylated but not monomethylated H3 'Lys-4'. Regulates specific gene transcription through DNA-binding on 5'-CCGCCC-3' motif. May stimulate transcription mediated by nuclear receptors. Involved in transcriptional regulation of Hox proteins during cell differentiation. May participate in transcriptional repression of cytokines such as CXCL12. Plays a role in the regulation of the circadian rhythm and in maintaining the normal periodicity of the circadian clock. In a histone demethylase-independent manner, acts as a coactivator of the CLOCK-ARNTL/BMAL1-mediated transcriptional activation of PER1/2 and other clock-controlled genes and increases histone acetylation at PER1/2 promoters by inhibiting the activity of HDAC1. Seems to act as a transcriptional corepressor for some genes such as MT1F and to favor the proliferation of cancer cells. |
| 偶联 | Unconjugated |
| 免疫原 | Recombinant Protein |
| Uniprot ID |
| 分子量 | Theoretical: 192 kDa. |
存储&运输
| 储存方式 | Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. |
| 运输方式 | Shipping with blue ice. |
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比如您的给药剂量是 10 mg/kg ，每只动物体重 20 g ，给药体积 100 μL ， 
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