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Anti-Protective protein/Cathepsin A Polyclonal Antibody

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货号 TMAB-11806

Anti-Protective protein/Cathepsin A Polyclonal Antibody 是一种 Rabbit 抗体，靶向 Protective protein/Cathepsin A。Anti-Protective protein/Cathepsin A Polyclonal Antibody 可用于 WB,IHC-P,IHC-Fr,IF。

Anti-Protective protein/Cathepsin A Polyclonal Antibody

Anti-Protective protein/Cathepsin A Polyclonal Antibody

一键复制产品信息
Rating icon 还可以
货号 TMAB-11806

Anti-Protective protein/Cathepsin A Polyclonal Antibody 是一种 Rabbit 抗体，靶向 Protective protein/Cathepsin A。Anti-Protective protein/Cathepsin A Polyclonal Antibody 可用于 WB,IHC-P,IHC-Fr,IF。

规格价格库存数量
50 μL
¥ 1,160
5日内发货
100 μL
¥ 1,965
5日内发货
200 μL
¥ 2,795
5日内发货
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产品介绍

生物活性
产品描述
Anti-Protective protein/Cathepsin A Polyclonal Antibody is a Rabbit antibody targeting Protective protein/Cathepsin A. Anti-Protective protein/Cathepsin A Polyclonal Antibody can be used in WB,IHC-P,IHC-Fr,IF.
Ig Type
IgG
反应种属
Human,Mouse,Rat (predicted:Dog,Pig,Cow,Horse)
应用WBIHC-PIHC-FrIF
推荐剂量
WB: 1:500-2000; IHC-P: 1:100-500; IHC-Fr: 1:100-500; IF: 1:100-500
抗体种类
Polyclonal
宿主来源Rabbit
亚细胞定位Lysosome.
构建方式Hybridoma Polyclonal Antibody
纯化方式Protein A purified
性状Liquid
缓冲液0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
浓度1mg/ml
研究背景Lysosomal protective protein/cathepsin A (PPCA) is a lysosomal serine carboxypeptidase that forms an intralysosomal enzyme complex with ?galactosidase and neuraminidase (NEU1). PPCA is synthesized as a 54 kDa precursor/zymogen, and proteolytically cleaved in the lysosome into a catalytically active 32 and 20 kDa two chain enzyme. The enzyme has cathepsin A activity at acidic pH but maintains also a deamidase/esterase activity at neutral pH. Furthermore, the human enzyme, purified from platelets and lymphocytes, has been shown to function on the inactivation of selected neuropeptides, like substance P, oxytocin, and endothelin I. The autosomal recessive genetic deficiency of PPCA causes galactosialidosis, a neurodegenerative lysosomal storage disorder, resulting in the secondary deficiencies of ?galactosidase and NEU1.
抗原信息
免疫原
KLH conjugated synthetic peptide: human Protective protein
抗原种属
Human
基因名称
CTSA
基因ID
5476
蛋白名称
Lysosomal protective protein
Uniprot ID
P10619
功能
Protective protein appears to be essential for both the activity of beta-galactosidase and neuraminidase, it associates with these enzymes and exerts a protective function necessary for their stability and activity. This protein is also a carboxypeptidase and can deamidate tachykinins.
化学信息
分子量Theoretical: 51 kDa.
储存&溶解度
储存方式Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles.
运输方式Shipping with blue ice.
存储store at low temperature | -20°C for 1 year

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