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Anti-RON/CD136 Antibody (9E783)
还可以产品编号 TMAY-01925
Anti-RON/CD136 Antibody (9E783) 是一种 Mouse 抗体，靶向 RON/CD136。Anti-RON/CD136 Antibody (9E783) 可用于 FCM。
Anti-RON/CD136 Antibody (9E783)
Anti-RON/CD136 Antibody (9E783)
还可以产品编号 TMAY-01925
Anti-RON/CD136 Antibody (9E783) 是一种 Mouse 抗体，靶向 RON/CD136。Anti-RON/CD136 Antibody (9E783) 可用于 FCM。
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| 产品描述 | Anti-RON/CD136 Antibody (9E783) is a Mouse antibody targeting RON/CD136. Anti-RON/CD136 Antibody (9E783) can be used in FCM. |
| Ig Type | Monoclonal Mouse IgG2b |
| 克隆号 | 9E783 |
| 交叉反应 | Human |
| 验证活性 | Flow cytometric analysis of Human CD136 expression on SW480 cells. Cells were stained with purified anti-Human LILRA3(CD85e), then a FITC-conjugated second step antibody. The fluorescence histograms were derived from gated events with the forward and side light-scatter characteristics of intact cells |
| 应用 | FCM |
| 推荐剂量 | FCM: 1:25-1:100 |
| 抗体种类 | Monoclonal |
| 宿主来源 | Mouse |
| 构建方式 | This antibody was produced from a hybridoma resulting from the fusion of a mouse myeloma with B cells obtained from a mouse immunized with purified, recombinant Human CD136/MST1R (rh CD136/MST1R; TMPY-02028; Q04912; Met1-Leu571). The IgG fraction of the cell culture supernatant was purified by Protein A affinity chromatography. |
| 纯化方式 | Protein A |
| 性状 | Liquid |
| 缓冲液 | 0.2 μm filtered solution in PBS |
| 研究背景 | The tyrosine kinase receptor, macrophage-stimulating 1 receptor (MST1R), a c-met-related tyrosine kinase, also known as the Ron receptor or CD136, controls cell survival and motility programs related to invasive growth. As the tyrosine kinase receptor is comprised of an extracellular domain, MST1R protein contains the ligand-binding pocket and an intracellular region where the kinase domain is located. MST1R signaling may be involved in the regulation of macrophage and T-lymphocyte activation in vivo during injury. This assessment of gene expression indicates the importance of genetic factors in contributing to lung injury and points to strategies for intervention in the progression of inflammatory diseases. It had been shown that MST1R/CD136 plays a critical role in Ni-induced lung injury in mice. The overexpression of MSP, MT-SP1, and MST1R was a strong independent indicator of both metastasis and death in human breast cancer patients and significantly increased the accuracy of an existing gene expression signature for poor prognosis. Stimulation of MST1R leads to its transphosphorylation and the ultimate activation of numerous intracellular signaling pathways, such as the classical mitogen-activated protein kinase pathway, the phosphatidylinositol (PI)3-kinase pathway, and the JNK pathway. |
| 偶联 | Unconjugated |
| 其他可选修饰符 | FITC/PE |
| 可提供抗体种类 | 3 |
| 免疫原 | Recombinant Human CD136/MST1R Protein (TMPY-02028) |
| 抗原种属 | Human |
| 研究领域 | Receptor Tyrosine Kinases (RTKs) |
存储&运输
| 储存方式 | Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. Preservative-Free. |
| 运输方式 | Shipping with blue ice. |
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比如您的给药剂量是 10 mg/kg ，每只动物体重 20 g ，给药体积 100 μL ， 
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