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顶部产品介绍抗原信息化学信息储存和溶解信息计算器

Anti-NCR3 Polyclonal Antibody

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货号 TMAB-09290

Anti-NCR3 Polyclonal Antibody 是一种 Rabbit 抗体，靶向 NCR3。Anti-NCR3 Polyclonal Antibody 可用于 FCM。

Anti-NCR3 Polyclonal Antibody

Anti-NCR3 Polyclonal Antibody

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Rating icon 还可以
货号 TMAB-09290

Anti-NCR3 Polyclonal Antibody 是一种 Rabbit 抗体，靶向 NCR3。Anti-NCR3 Polyclonal Antibody 可用于 FCM。

规格价格库存数量
50 μL
¥ 1,160
5日内发货
100 μL
¥ 1,965
5日内发货
200 μL
¥ 2,795
5日内发货
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产品介绍

生物活性
产品描述
Anti-NCR3 Polyclonal Antibody is a Rabbit antibody targeting NCR3. Anti-NCR3 Polyclonal Antibody can be used in FCM.
Ig Type
IgG
反应种属
Human (predicted:Rat,Dog,Horse,Rabbit)
应用FCM
推荐剂量
FCM: 2μg/Test
抗体种类
Polyclonal
宿主来源Rabbit
亚细胞定位Cell membrane; Single-pass type I membrane protein.
组织特异性Selectively expressed by all resting and activated NK cells and weakly expressed in spleen.
构建方式Hybridoma Polyclonal Antibody
纯化方式Protein A purified
性状Liquid
缓冲液0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
浓度1mg/ml
研究背景NCR3 is a cytotoxicity-activating receptor that may contribute to the increased efficiency of activated natural killer (NK) cells to mediate tumor cell lysis. It is a member of the Ig superfamily and may cooperate with NKp46 and NKp44 in the induction of cytotoxicity against a variety of target cells and is selectively expressed by all NK cells, both freshly isolated and cultured in IL2, thus representing an optimal marker for NK cell identification. Similar to NKp46 and CD16, NKp30 associated with CD3 zeta chains becomes tyrosine phosphorylated following cell treatment with pervanadate. Its extracelluar portion is characterized by a single domain of the V-type and by a region rich in hydrophobic amino acids, potentially involved in protein/protein interactions that connects the Ig V-like domain with the transmembrane portion. It is selectively expressed by all resting and activated NK cells and weakly expressed in spleen.
抗原信息
免疫原
KLH conjugated synthetic peptide: human CD337
抗原种属
Human
基因名称
NCR3
基因ID
259197
蛋白名称
Natural cytotoxicity triggering receptor 3
Uniprot ID
O14931
功能
Cytotoxicity-activating receptor that contributes to the increased efficiency of activated natural killer (NK) cells to mediate tumor cell lysis. Engagement of NCR3 by BAG6 also promotes dendritic cell (DC) maturation, both through killing those DCs that did not properly acquire a mature phenotype, and inducing NK cells to release TNFA and IFNG, which promotes DC maturation.
化学信息
分子量Theoretical: 20 kDa.
储存&溶解度
储存方式Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles.
运输方式Shipping with blue ice.
存储store at low temperature | -20°C for 1 year

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