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HBED

Name: HBED
Brand: TargetMol
SKU: T32046
Price: 143 CNY
Availability: InStock
Rating: 5 (10 reviews)

Synonyms: CHEL-II, CHELII, CHEL II

货号 T32046Cas号 35998-29-9 一键复制产品信息纯度: 98.58%

很棒

HBED (CHELII) 是一种铁螯合剂，可用于治疗慢性铁过载和急性铁中毒的研究。

HBED

一键复制产品信息

很棒

纯度: 98.58%

货号 T32046Cas号 35998-29-9

别名 CHEL-II, CHELII, CHEL II

HBED (CHELII) 是一种铁螯合剂，可用于治疗慢性铁过载和急性铁中毒的研究。

为众多的药物研发团队赋能，

让新药发现更简单！

规格	价格	库存
2 mg	¥ 143	现货
5 mg	¥ 198	现货
10 mg	¥ 289	现货
25 mg	¥ 458	现货
50 mg	¥ 662	现货
100 mg	¥ 968	现货
500 mg	¥ 2,380	现货
1 mL x 10 mM (in DMSO)	¥ 195	现货

库存状态实时更新，以官网显示为准，现货产品可直接加购物车下单

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TargetMol的所有产品仅用作科学研究或药证申报，不能被用于人体，我们不向个人提供产品和服务。请您遵守承诺用途，不得违反法律法规规定用于任何其他用途。

该分子属于定制产品。TargetMol拥有优秀的合成团队，经验和能力，可以为您提供高性价比的产品。如您有任何问题，欢迎咨询，我们将竭诚为您服务。

实验操作小课堂

常见问题解答

选择批次:

纯度: 98.58%

颜色: 白色

性状: Solid

资源下载: COA LCMS HNMR产品操作手册

产品介绍

HBED AI Summary

HBED demonstrates multiple bioactivities related to iron metabolism and toxicity in animal models. When administered intraperitoneally at different dosages, it affects iron levels in various organs such as the spleen, liver, feces, and urine, with both increases and decreases observed. The LD50 value for intraperitoneal administration in an iron overload rat model is greater than or equal to 800.0 mg/kg. The compound has varying ionization constants (pKa values) and differences in partition coefficients (logP) in different solvents, indicating its interactions in various pH environments and biological systems. It is suitable for use in organic solvents such as MeOH, chloroform, and cyclohexane, which highlights its applicability in different experimental setups or biological assays. Despite its low absorption rate of 5.0% in the human GI-tract and low effective permeability across a hexadecane membrane (Log Pe value of -5.1 cm s-1), the compound has near-neutral partitioning (LogD value of -0.2). HBED exhibits strong iron chelating activity, evidenced by a high stability constant of the Fe3+-compound complex (log K value of 40.0). It serves as a transporter substrate and shows interactions with various transporters in human Caco2 cells. The compound's efflux ratios vary with and without specific inhibitors, and its permeability is influenced by P-gp and MRP2 inhibitors, showing a high transporter substrate index ratio when treated with the MRP2 inhibitor MK571..

Note: Summary generated by AI. Data source: ChEMBL

生物活性

产品描述	HBED (CHELII) is an iron chelator and can be used in research on the treatment of chronic iron overload and acute iron poisoning.
别名	CHEL-II, CHELII, CHEL II

化学信息

分子量	388.41
分子式	C₂₀H₂₄N₂O₆
CAS No.	35998-29-9
Smiles	C(N(CCN(CC1=C(O)C=CC=C1)CC(O)=O)CC(O)=O)C2=C(O)C=CC=C2
密度	1.374g/cm3

储存&溶解度

存储

Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature.

实际储存温度请以COA为准

溶解度信息

DMSO: 5 mg/mL (12.87 mM), Sonication is recommended.

溶液配制表

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.5746 mL	12.8730 mL	25.7460 mL	128.7300 mL
5 mM	0.5149 mL	2.5746 mL	5.1492 mL	25.7460 mL
10 mM	0.2575 mL	1.2873 mL	2.5746 mL	12.8730 mL

该溶液配制表仅适用于固体产品。对于液体产品，请根据标明的浓度或密度计算稀释方案。

计算器

摩尔浓度计算器
稀释计算器
配液计算器
分子量计算器

体内实验配液计算器

请在以下方框中输入您的动物实验信息后点击计算，可以得到母液配置方法和体内配方的制备方法：

比如您的给药剂量是10 mg/kg，每只动物体重20 g，给药体积100 μL，一共给药动物10只，您使用的配方为 10% DMSO + 40% PEG300 + 5% Tween 80 + 45% Saline / PBS / ddH₂O，那么您的工作液浓度为2 mg/mL。

母液配置方法：2 mg 药物溶于 100 μL DMSO （母液浓度为 20 mg/mL ）, 如您需要配置的浓度超过该产品的溶解度，请先与我们联系。