购物车
您的购物车当前为空
HBED
一键复制产品信息
很棒纯度: 98.58%
货号 T32046Cas号 35998-29-9
别名 CHEL-II, CHELII, CHEL II
HBED (CHELII) 是一种铁螯合剂，可用于治疗慢性铁过载和急性铁中毒的研究。
为众多的药物研发团队赋能，
让新药发现更简单！
HBED
一键复制产品信息 很棒纯度: 98.58%
货号 T32046 别名 CHEL-II, CHELII, CHEL IICas号 35998-29-9
HBED (CHELII) 是一种铁螯合剂，可用于治疗慢性铁过载和急性铁中毒的研究。
| 规格 | 价格 | 库存 | 数量 |
|---|---|---|---|
| 2 mg | ¥ 143 | 现货 | |
| 5 mg | ¥ 198 | 现货 | |
| 10 mg | ¥ 289 | 现货 | |
| 25 mg | ¥ 458 | 现货 | |
| 50 mg | ¥ 662 | 现货 | |
| 100 mg | ¥ 968 | 现货 | |
| 500 mg | ¥ 2,380 | 现货 | |
| 1 mL x 10 mM (in DMSO) | ¥ 195 | 现货 |
库存状态实时更新，以官网显示为准，现货产品可直接加购物车下单
大包装 & 定制
加入购物车
该分子属于定制产品。TargetMol拥有优秀的合成团队，经验和能力，可以为您提供高性价比的产品。 如您有任何问题，欢迎咨询，我们将竭诚为您服务。
产品介绍
HBED AI Summary
HBED demonstrates multiple bioactivities related to iron metabolism and toxicity in animal models. When administered intraperitoneally at different dosages, it affects iron levels in various organs such as the spleen, liver, feces, and urine, with both increases and decreases observed. The LD50 value for intraperitoneal administration in an iron overload rat model is greater than or equal to 800.0 mg/kg. The compound has varying ionization constants (pKa values) and differences in partition coefficients (logP) in different solvents, indicating its interactions in various pH environments and biological systems. It is suitable for use in organic solvents such as MeOH, chloroform, and cyclohexane, which highlights its applicability in different experimental setups or biological assays. Despite its low absorption rate of 5.0% in the human GI-tract and low effective permeability across a hexadecane membrane (Log Pe value of -5.1 cm s-1), the compound has near-neutral partitioning (LogD value of -0.2). HBED exhibits strong iron chelating activity, evidenced by a high stability constant of the Fe3+-compound complex (log K value of 40.0). It serves as a transporter substrate and shows interactions with various transporters in human Caco2 cells. The compound's efflux ratios vary with and without specific inhibitors, and its permeability is influenced by P-gp and MRP2 inhibitors, showing a high transporter substrate index ratio when treated with the MRP2 inhibitor MK571..
Note: Summary generated by AI. Data source: ChEMBL 
生物活性
化学信息
储存&溶解度
| 产品描述 | HBED (CHELII) is an iron chelator and can be used in research on the treatment of chronic iron overload and acute iron poisoning. |
| 别名 | CHEL-II, CHELII, CHEL II |
| 分子量 | 388.41 |
| 分子式 | C20H24N2O6 |
| CAS No. | 35998-29-9 |
| Smiles | C(N(CCN(CC1=C(O)C=CC=C1)CC(O)=O)CC(O)=O)C2=C(O)C=CC=C2 |
| 密度 | 1.374g/cm3 |
| 存储 | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. | ||||||||||||||||||||
| 溶解度信息 | DMSO: 5 mg/mL (12.87 mM), Sonication is recommended.  | ||||||||||||||||||||
溶液配制表 | |||||||||||||||||||||
DMSO
| |||||||||||||||||||||
计算器
体内实验配液计算器
请在以下方框中输入您的动物实验信息后点击计算，可以得到母液配置方法和体内配方的制备方法：
比如您的给药剂量是10 mg/kg，每只动物体重20g，给药体积100 μL， 一共给药动物10只，您使用的配方为5%
DMSO + 30%PEG300 + 5%Tween 80 + 60%Saline/PBS/ddH2O， 那么您的工作液浓度为2mg/mL。 以上为“体内实验配液计算器”的使用方法举例，并不是具体某个化合物的推荐配制方式，请根据您的实验动物和给药方式选择适当的溶解方案。
剂量转换
对于不同动物的给药剂量换算，您也可以参考 更多
预览
Related Tags: buy HBED | purchase HBED | HBED cost | order HBED | HBED chemical structure | HBED formula | HBED molecular weight
嗨！有任何问题？点我咨询
版权所有©2015-2026 TargetMol Chemicals Inc.保留所有权利.
沪ICP备20019793号-4 | 沪公网安备 31010602006700号
| 沪(静)应急管危经许[2024]203441