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顶部产品介绍抗原信息化学信息储存和溶解信息计算器

Anti-GPR40 Polyclonal Antibody

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货号 TMAB-00794

别名 G-protein coupled receptor 40, GPR 40, GPCR GPR40, GPCR 40, Free fatty acid receptor 1, FFAR1, FFAR 1, FFA1R

Anti-GPR40 Polyclonal Antibody 是一种 Rabbit 抗体，靶向 GPR40。Anti-GPR40 Polyclonal Antibody 可用于 IF,IHC-Fr,IHC-P。

Anti-GPR40 Polyclonal Antibody

Anti-GPR40 Polyclonal Antibody

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Rating icon 还可以
货号 TMAB-00794 别名 G-protein coupled receptor 40, GPR 40, GPCR GPR40, GPCR 40, Free fatty acid receptor 1, FFAR1, FFAR 1, FFA1R

Anti-GPR40 Polyclonal Antibody 是一种 Rabbit 抗体，靶向 GPR40。Anti-GPR40 Polyclonal Antibody 可用于 IF,IHC-Fr,IHC-P。

规格价格库存数量
50 μL
¥ 1,165
5日内发货
100 μL
¥ 1,965
5日内发货
200 μL
¥ 2,780
5日内发货
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产品介绍

生物活性
产品描述
Anti-GPR40 Polyclonal Antibody is a Rabbit antibody targeting GPR40. Anti-GPR40 Polyclonal Antibody can be used in IF,IHC-Fr,IHC-P.
别名G-protein coupled receptor 40, GPR 40, GPCR GPR40, GPCR 40, Free fatty acid receptor 1, FFAR1, FFAR 1, FFA1R
Ig Type
IgG
反应种属
Human (predicted:Mouse,Rat,Dog,Pig)
验证活性
Tissue/cell: human lung carcinoma; 4% Paraformaldehyde-fixed and paraffin-embedded;
Antigen retrieval: citrate buffer (0.01M, pH6.0), Boiling bathing for 15 min; Block endogenous peroxidase by 3% Hydrogen peroxide for 30 min; Blocking buffer (normal goat serum) at 37°C for 20 min;
Incubation: Anti-GPR40 Polyclonal Antibody, Unconjugated (TMAB-00794) 1:200, overnight at 4°C, followed by conjugation to the secondary antibody and DAb staining.
verifiedActivity
应用IFIHC-FrIHC-P
推荐剂量
IHC-P: 1:100-500; IHC-Fr: 1:100-500; IF: 1:100-500
抗体种类
Polyclonal
宿主来源Rabbit
亚细胞定位Cell membrane.
组织特异性Expressed abundantly in pancreatic beta cells.
构建方式Polyclonal Antibody
纯化方式Protein A purified
性状Liquid
缓冲液0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
浓度1 mg/mL
研究背景G protein coupled receptors provide attractive targets for drug therapy due to the sheer size and diversity of ligands within this receptor family. G protein-coupled receptor 40 (GPR40) functions as a cell-surface receptor for long-chain free fatty acids (FFAs). FFAs provide an important energy source, but also function as signaling molecules in various pathways, notably the process of insulin secretion. In pancreatic tissue, the interaction of long chain FFAs with GPR40 amplifies glucose-stimulated insulin secretion from beta cells, suggesting a possible role for GPR40 in the treatment of diabetes associated with insulin-deficiency. Specifically, the Arg211His polymorphism in the GPR40 gene may contribute to the variation of insulin secretory capacity in Japanese men. Also, GPR40 may be involved in the control of breast cancer cell growth by fatty acids and, therefore, provide a link between fat and cancer.
抗原信息
免疫原
KLH conjugated synthetic peptide: human GPR40
抗原种属
Human
基因名称
FFAR1
基因ID
2864
蛋白名称
Free fatty acid receptor 1
Uniprot ID
O14842
研究领域
GPCR
功能
Receptor for medium and long chain saturated and unsaturated fatty acids. Binding of the ligand increase intracellular calcium concentration and amplify glucose-stimulated insulin secretion. The activity of this receptor is mediated by G-proteins that activate phospholipase C. Seems to act through a G(q) and G(i)-mediated pathway.
化学信息
分子量Theoretical: 32 kDa.
储存&溶解度
储存方式Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles.
运输方式Shipping with blue ice.
存储store at low temperature | store at -20°C

计算器

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